HitPredict

Interactor 1: BMI1 (P35226)
Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)
Gene: BMI1

Interactor 2: H2B1C (P62807)
Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l)
Gene: H2BC4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	34316702
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 326 Hs			1 126
+	Hs
		717877 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21
+	Hs
		707534 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62
+	Hs
		717607 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		H2B1D_HUMAN (1-126): 3.24e-53: 164: 99.21
+	Hs
		718401 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21
+	Hs
		1087375 PCGF1_HUMAN (2-229): 5.96e-62: 199: 36.33		H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21
+	Hs
		918649 PCGF1_HUMAN (2-229): 5.96e-62: 199: 36.33		H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00
+	Hs
		1087359 RING2_HUMAN (7-227): 8.37e-50: 170: 16.61		H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21
+	Hs
		918631 RING2_HUMAN (7-227): 8.37e-50: 170: 16.61		H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00
+	Hs
		707723 RING2_HUMAN (7-227): 8.37e-50: 170: 16.61		H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62
+	Hs
		1231231 RING2_HUMAN (7-227): 8.37e-50: 170: 16.61		H2B3B_HUMAN (1-126): 8.29e-52: 161: 95.24
+	Mm
		1145466 CHFR_MOUSE (6-167): 1.07e-33: 132: 19.39		H2B2E_MOUSE (1-126): 1.08e-52: 163: 96.03
+	Hs
		918311 RING1_HUMAN (7-115): 2.38e-30: 120: 25.46		H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00
+	Hs
		707600 RING1_HUMAN (7-115): 2.38e-30: 120: 25.46		H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62
+	Hs
		282669 RNF8_HUMAN (2-101): 3.38e-21: 95.7: 25.00		H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21
+	Hs
		282550 RNF8_HUMAN (2-101): 3.38e-21: 95.7: 25.00		H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62
+	Mm
		1145467 RNF8_MOUSE (2-102): 4.69e-20: 92.2: 26.73		H2B2E_MOUSE (1-126): 1.08e-52: 163: 96.03