Protein: ZN281
Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99)

Gene: ZN281, ZNF281
Organism: Homo sapiens
Interactions: 185
UniProt ID: Q9Y2X9

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

891903

GSK3B
Glycogen synthase kinase-3 beta

1

4

Small-scale

0.724

High

625720

CSK22
Casein kinase II subunit alpha'

1

4

High-throughput

0.691

High

1116159

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

4

High-throughput

0.691

High

1161271

MK06
Mitogen-activated protein kinase 6

1

5

High-throughput

0.691

High

1337133

HIPK4
Homeodomain-interacting protein kinase 4

1

5

High-throughput

0.691

High

1434514

ZN644
Zinc finger protein 644

1

13

High-throughput

0.691

High

1490995

LMBL1
Lethal(3)malignant brain tumor-like protein 1

3

1

High-throughput

0.675

High

373559

MYC
Myc proto-oncogene protein

3

2

High-throughput

0.672

High

254000

LPXN
Leupaxin

3

18

High-throughput

0.662

High

872916

SOX2
Transcription factor SOX-2

3

14

Small-scale

0.640

High

1093093

CDC16
Cell division cycle protein 16 homolog

2

2

High-throughput

0.628

High

1461013

FBW1B
F-box/WD repeat-containing protein 11

2

1

Small-scale

0.624

High

1051440

ZBT16
Zinc finger and BTB domain-containing protein 16

1

14

High-throughput

0.621

High

158015

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.618

High

217004

KLF4
Krueppel-like factor 4

1

19

High-throughput

0.618

High

339904

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.618

High

538496

EGR2
E3 SUMO-protein ligase EGR2

1

18

High-throughput

0.618

High

881631

CDK8
Cyclin-dependent kinase 8

1

4

High-throughput

0.618

High

897432

CDK7
Cyclin-dependent kinase 7

1

2

High-throughput

0.618

High

944770

KLF3
Krueppel-like factor 3

1

19

High-throughput

0.618

High

1040950

MECOM
Histone-lysine N-methyltransferase MECOM

1

15

High-throughput

0.618

High

1118797

KLF5
Krueppel-like factor 5

1

19

High-throughput

0.618

High

1332728

ZBT38
Zinc finger and BTB domain-containing protein 38

1

18

Small-scale

0.618

High

1351206

SP7
Transcription factor Sp7

1

18

High-throughput

0.618

High

1416965

KLF16
Krueppel-like factor 16

1

18

High-throughput

0.618

High

1460392

KLF15
Krueppel-like factor 15

1

18

High-throughput

0.618

High

1490996

KLF12
Krueppel-like factor 12

1

20

High-throughput

0.618

High

644144

FBRL
rRNA 2'-O-methyltransferase fibrillarin

2

3

High-throughput

0.611

High

1257266

RFPLB
Ret finger protein-like 4B

2

7

High-throughput

0.611

High

474393

NFIC
Nuclear factor 1 C-type

2

10

High-throughput

0.601

High

1088115

NFIA
Nuclear factor 1 A-type

2

10

High-throughput

0.601

High

1133750

NFIX
Nuclear factor 1 X-type

2

10

High-throughput

0.601

High

827969

STAT3
Signal transducer and activator of transcription 3

2

1

High-throughput

0.594

High

1249459

OLFM4
Olfactomedin-4

2

0

High-throughput

0.585

High

143345

NFIB
Nuclear factor 1 B-type

2

10

High-throughput

0.584

High

386384

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

2

11

High-throughput

0.584

High

998982

H31
Histone H3.1

2

12

High-throughput

0.584

High

1314494

SLX4
Structure-specific endonuclease subunit SLX4

2

2

High-throughput

0.584

High

1437246

NANOG
Homeobox protein NANOG

2

13

Small-scale

0.584

High

1211469

CF141
Uncharacterized protein C6orf141

2

1

High-throughput

0.574

High

397278

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1433487

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

2

High-throughput

0.553

High

1364899

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

3

High-throughput

0.542

High

1428884

EGLN1
Egl nine homolog 1

1

1

High-throughput

0.541

High

1101934

SKP2
S-phase kinase-associated protein 2

1

2

High-throughput

0.536

High

1250698

BCOR
BCL-6 corepressor

1

6

Small-scale

0.536

High

1332999

MLKL
Mixed lineage kinase domain-like protein

1

2

High-throughput

0.536

High

1433139

CHM4B
Charged multivesicular body protein 4b

1

1

High-throughput

0.536

High

1462297

MAGD2
Melanoma-associated antigen D2

1

4

High-throughput

0.536

High

1490997

NGN3
Neurogenin-3

1

3

High-throughput

0.536

High

844118

HD
Huntingtin

1

4

High-throughput

0.515

High

1386640

OPTN
Optineurin

1

4

High-throughput

0.515

High

944112

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

2

High-throughput

0.514

High

1367763

PRCC
Proline-rich protein PRCC

1

0

High-throughput

0.513

High

1460262

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.513

High

269475

KI21B
Kinesin-like protein KIF21B

1

3

High-throughput

0.489

High

880222

PTH2R
Parathyroid hormone 2 receptor

1

2

High-throughput

0.489

High

1101477

KCAB2
Voltage-gated potassium channel subunit beta-2

1

1

High-throughput

0.489

High

1128973

I13R2
Interleukin-13 receptor subunit alpha-2

1

1

High-throughput

0.489

High

1178923

CF184
Cilia- and flagella-associated protein 184

1

1

High-throughput

0.489

High

1251916

THSD4
Thrombospondin type-1 domain-containing protein 4

1

1

High-throughput

0.489

High

1275457

GRIN1
G protein-regulated inducer of neurite outgrowth 1

1

7

High-throughput

0.489

High

1331621

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

1

High-throughput

0.489

High

1348365

GOGA5
Golgin subfamily A member 5

1

5

High-throughput

0.489

High

1429453

DRC3
Dynein regulatory complex subunit 3

1

2

High-throughput

0.489

High

1490972

TDRKH
Tudor and KH domain-containing protein

1

2

High-throughput

0.489

High

129577

MEN1
Menin

1

2

High-throughput

0.479

High

174645

TRI66
Tripartite motif-containing protein 66

1

20

High-throughput

0.479

High

181583

TBXT
T-box transcription factor T

1

3

High-throughput

0.479

High

191170

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

1

High-throughput

0.479

High

194631

KDM6A
Lysine-specific demethylase 6A

1

4

Small-scale

0.479

High

225143

TLX3
T-cell leukemia homeobox protein 3

1

13

High-throughput

0.479

High

226623

TLX2
T-cell leukemia homeobox protein 2

1

8

High-throughput

0.479

High

240019

SOX15
Transcription factor SOX-15

1

14

High-throughput

0.479

High

260638

BRD4
Bromodomain-containing protein 4

1

9

High-throughput

0.479

High

323619

TRI37
E3 ubiquitin-protein ligase TRIM37

1

11

High-throughput

0.479

High

331438

KI20A
Kinesin-like protein KIF20A

1

5

High-throughput

0.479

High

342380

BRD1
Bromodomain-containing protein 1

1

3

High-throughput

0.479

High

404561

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

425686

ISG15
Ubiquitin-like protein ISG15

1

7

High-throughput

0.479

High

487904

PARP1
Poly [ADP-ribose] polymerase 1

1

3

High-throughput

0.479

High

519441

MYB
Transcriptional activator Myb

1

1

High-throughput

0.479

High

520474

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

540973

ERG
Transcriptional regulator ERG

1

10

High-throughput

0.479

High

581744

MYOD1
Myoblast determination protein 1

1

1

High-throughput

0.479

High

607247

CEBPB
CCAAT/enhancer-binding protein beta

1

10

High-throughput

0.479

High

659321

SP100
Nuclear autoantigen Sp-100

1

9

High-throughput

0.479

High

662301

PAX7
Paired box protein Pax-7

1

4

High-throughput

0.479

High

662523

GATA2
Endothelial transcription factor GATA-2

1

3

High-throughput

0.479

High

662678

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

3

High-throughput

0.479

High

685395

PAX6
Paired box protein Pax-6

1

3

High-throughput

0.479

High

697303

APEX1
DNA repair nuclease/redox regulator APEX1

1

1

High-throughput

0.479

High

703219

TEAD1
Transcriptional enhancer factor TEF-1

1

1

High-throughput

0.479

High

714538

PML
Protein PML

1

20

High-throughput

0.479

High

725344

TLX1
T-cell leukemia homeobox protein 1

1

11

High-throughput

0.479

High

775940

HNF1B
Hepatocyte nuclear factor 1-beta

1

6

High-throughput

0.479

High

776270

SOX6
Transcription factor SOX-6

1

14

High-throughput

0.479

High

800182

COIL
Coilin

1

3

High-throughput

0.479

High

834099

HNF4A
Hepatocyte nuclear factor 4-alpha

1

13

High-throughput

0.479

High

837111

ELK3
ETS domain-containing protein Elk-3

1

12

High-throughput

0.479

High

851710

GATA4
Transcription factor GATA-4

1

3

High-throughput

0.479

High

855544

ATRX
Transcriptional regulator ATRX

1

4

Small-scale

0.479

High

873134

SOX9
Transcription factor SOX-9

1

16

High-throughput

0.479

High

887362

CEBPA
CCAAT/enhancer-binding protein alpha

1

10

High-throughput

0.479

High

913823

ZN131
Zinc finger protein 131

1

19

High-throughput

0.479

High

928596

TERF1
Telomeric repeat-binding factor 1

1

1

High-throughput

0.479

High

942130

SOX10
Transcription factor SOX-10

1

15

High-throughput

0.479

High

980576

H4
Histone H4

1

4

High-throughput

0.479

High

981190

H2B1C
Histone H2B type 1-C/E/F/G/I

1

3

High-throughput

0.479

High

1005269

RNF4
E3 ubiquitin-protein ligase RNF4

1

17

High-throughput

0.479

High

1017318

H33
Histone H3.3

1

12

High-throughput

0.479

High

1033824

PO5F1
POU domain, class 5, transcription factor 1

1

5

Small-scale

0.479

High

1045937

TF65
Transcription factor p65

1

4

High-throughput

0.479

High

1048140

TLE3
Transducin-like enhancer protein 3

1

2

High-throughput

0.479

High

1097642

CBX3
Chromobox protein homolog 3

1

20

High-throughput

0.479

High

1137601

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.479

High

1141377

BRD3
Bromodomain-containing protein 3

1

9

High-throughput

0.479

High

1142037

EEA1
Early endosome antigen 1

1

7

High-throughput

0.479

High

1150029

TERF2
Telomeric repeat-binding factor 2

1

1

High-throughput

0.479

High

1152764

ELF2
ETS-related transcription factor Elf-2

1

10

High-throughput

0.479

High

1155932

EZH2
Histone-lysine N-methyltransferase EZH2

1

4

High-throughput

0.479

High

1277004

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

1278988

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

5

High-throughput

0.479

High

1289739

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1313556

SMC5
Structural maintenance of chromosomes protein 5

1

3

High-throughput

0.479

High

1339053

NUP43
Nucleoporin Nup43

1

3

High-throughput

0.479

High

1359731

PHIP
PH-interacting protein

1

2

High-throughput

0.479

High

1367648

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1387655

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

4

High-throughput

0.479

High

1401064

PHF12
PHD finger protein 12

1

9

High-throughput

0.479

High

1405463

FEV
Protein FEV

1

10

High-throughput

0.479

High

1434421

RNF41
E3 ubiquitin-protein ligase NRDP1

1

12

Small-scale

0.479

High

1434986

SOX17
Transcription factor SOX-17

1

14

High-throughput

0.479

High

1435482

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1438098

RC3H2
Roquin-2

1

1

High-throughput

0.479

High

1452489

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

1459389

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1461298

ELF5
ETS-related transcription factor Elf-5

1

11

High-throughput

0.479

High

1490994

ZN330
Zinc finger protein 330

1

3

High-throughput

0.479

High

1142435

PDIA6
Protein disulfide-isomerase A6

1

9

High-throughput

0.470

High

558513

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

590086

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

696924

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

769571

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

905318

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

1091383

FOXL1
Forkhead box protein L1

1

0

High-throughput

0.458

High

1146883

PCBP1
Poly(rC)-binding protein 1

1

0

High-throughput

0.458

High

1244848

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

1357174

GATD1
GATA zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

1403621

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

1429406

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

1490618

ASF1A
Histone chaperone ASF1A

1

0

High-throughput

0.458

High

564590

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

679416

DNJB2
DnaJ homolog subfamily B member 2

1

8

High-throughput

0.445

High

1108764

TBB3
Tubulin beta-3 chain

1

2

High-throughput

0.445

High

1259590

TBA1A
Tubulin alpha-1A chain

1

1

High-throughput

0.445

High

1325414

STAG2
Cohesin subunit SA-2

1

1

Small-scale

0.445

High

1358316

STAG1
Cohesin subunit SA-1

1

1

Small-scale

0.445

High

1453282

GRHL1
Grainyhead-like protein 1 homolog

1

2

High-throughput

0.445

High

294562

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.437

High

346534

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

17

High-throughput

0.437

High

942969

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.437

High

1258092

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

1

Small-scale

0.437

High

1434289

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.437

High

49044

MED19
Mediator of RNA polymerase II transcription subunit 19

1

0

High-throughput

0.426

High

1287576

RM52
Large ribosomal subunit protein mL52

1

0

High-throughput

0.426

High

294767

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

1

High-throughput

0.407

High

844901

EAA1
Excitatory amino acid transporter 1

1

1

High-throughput

0.407

High

1227746

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.407

High

635920

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

High-throughput

0.282

High

867536

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.279

Low

1043247

TAP2
Antigen peptide transporter 2

1

0

High-throughput

0.279

Low

1313749

MILK2
MICAL-like protein 2

1

0

High-throughput

0.279

Low

1350923

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

1409623

NIPS1
Protein NipSnap homolog 1

1

0

High-throughput

0.279

Low

1430727

OSBL5
Oxysterol-binding protein-related protein 5

1

0

High-throughput

0.279

Low

1435104

WDCP
WD repeat and coiled-coil-containing protein

1

0

High-throughput

0.279

Low

47436

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

1249352

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1332922

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

1010988

BAT1
b(0,+)-type amino acid transporter 1

1

0

High-throughput

0.232

Low

1270868

SV2A
Synaptic vesicle glycoprotein 2A

1

0

High-throughput

0.232

Low

1410961

ODC
Mitochondrial 2-oxodicarboxylate carrier

1

0

High-throughput

0.232

Low

1419170

S17A9
Voltage-gated purine nucleotide uniporter SLC17A9

1

0

High-throughput

0.232

Low

1490585

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025