HitPredict

Interactor 1: BMI1 (P35226)
Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)
Gene: BMI1

Interactor 2: H2A2A (Q6FI13)
Histone H2A type 2-A (H2A-clustered histone 18) (H2A-clustered histone 19) (Histone H2A.2) (Histone H2A/o)
Gene: H2AC18

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	21179169, 21772249
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Histone~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 326 Hs			1 130
+	Hs
		391572 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		H2A1B_HUMAN (1-130): 9.51e-67: 199: 96.92
+	Hs
		470285 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		H2A1_HUMAN (1-130): 6.85e-67: 199: 98.46
+	Hs
		717876 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		H2A2C_HUMAN (1-128): 2.7e-64: 193: 96.88
+	Hs
		555322 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		H2AX_HUMAN (1-130): 3.33e-63: 190: 88.81
+	Hs
		391879 PCGF1_HUMAN (2-229): 5.96e-62: 199: 36.33		H2A1B_HUMAN (1-130): 9.51e-67: 199: 96.92
+	Hs
		470533 PCGF1_HUMAN (2-229): 5.96e-62: 199: 36.33		H2A1_HUMAN (1-130): 6.85e-67: 199: 98.46
+	Hs
		555627 PCGF1_HUMAN (2-229): 5.96e-62: 199: 36.33		H2AX_HUMAN (1-130): 3.33e-63: 190: 88.81
+	Hs
		1151374 RING2_HUMAN (7-227): 8.37e-50: 170: 16.61		H2A2A_HUMAN (1-130): 4.66e-67: 200: 100.00
+	Hs
		1185208 RING2_HUMAN (7-227): 8.37e-50: 170: 16.61		H2A3_HUMAN (1-130): 6.2e-67: 199: 97.69
+	Hs
		391856 RING2_HUMAN (7-227): 8.37e-50: 170: 16.61		H2A1B_HUMAN (1-130): 9.51e-67: 199: 96.92
+	Hs
		470514 RING2_HUMAN (7-227): 8.37e-50: 170: 16.61		H2A1_HUMAN (1-130): 6.85e-67: 199: 98.46
+	Hs
		1216249 RING2_HUMAN (7-227): 8.37e-50: 170: 16.61		H2A2B_HUMAN (1-130): 1.54e-65: 196: 94.62
+	Hs
		1087089 RING2_HUMAN (7-227): 8.37e-50: 170: 16.61		H2A2C_HUMAN (1-128): 2.7e-64: 193: 96.88
+	Hs
		555611 RING2_HUMAN (7-227): 8.37e-50: 170: 16.61		H2AX_HUMAN (1-130): 3.33e-63: 190: 88.81
+	Mm
		1145461 CHFR_MOUSE (6-167): 1.07e-33: 132: 19.39		H2A2C_MOUSE (1-128): 2.7e-64: 193: 96.88
+	Hs
		391666 RING1_HUMAN (7-115): 2.38e-30: 120: 25.46		H2A1B_HUMAN (1-130): 9.51e-67: 199: 96.92
+	Hs
		555425 RING1_HUMAN (7-115): 2.38e-30: 120: 25.46		H2AX_HUMAN (1-130): 3.33e-63: 190: 88.81
+	Dm
		950442 RING1_DROME (7-128): 8.44e-30: 119: 22.22		H2A_DROME (17-125): 2.5e-59: 180: 89.91
+	Hs
		282470 RNF8_HUMAN (2-101): 3.38e-21: 95.7: 25.00		H2A1B_HUMAN (1-130): 9.51e-67: 199: 96.92
+	Hs
		282515 RNF8_HUMAN (2-101): 3.38e-21: 95.7: 25.00		H2AX_HUMAN (1-130): 3.33e-63: 190: 88.81