HitPredict

Interactor 1: BMI1 (P35226)
Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)
Gene: BMI1

Interactor 2: RYBP (Q8N488)
RING1 and YY1-binding protein (Apoptin-associating protein 1) (APAP-1) (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1)
Gene: RYBP

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.973

Property	Details
Experiments	26186194, 28514442, 27705803, 24981860, 33961781, 34316702, 22325352, 24457600, 20601937
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RAWUL~YAF2_RYBP
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling GO:0031519 - PcG protein complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 326 Hs			1 228
+	Hs
		718000 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		YAF2_HUMAN (3-227): 3.24e-55: 176: 52.89
+	Hs
		718410 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		RYBP_HUMAN (1-228): 2.79e-61: 193: 100.00
+	Mm
		620789 PCGF2_MOUSE (1-320): 5.49e-113: 332: 61.06		RYBP_MOUSE (1-228): 1.71e-61: 193: 99.12
+	Hs
		718409 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		YAF2_HUMAN (3-227): 3.24e-55: 176: 52.89
+	Hs
		1108517 PCGF3_HUMAN (4-228): 4.43e-72: 225: 34.03		RYBP_HUMAN (1-228): 2.79e-61: 193: 100.00
+	Hs
		1108516 PCGF3_HUMAN (4-228): 4.43e-72: 225: 34.03		YAF2_HUMAN (3-227): 3.24e-55: 176: 52.89
+	Hs
		1233190 PCGF6_HUMAN (2-235): 2.13e-61: 201: 35.12		RYBP_HUMAN (1-228): 2.79e-61: 193: 100.00
+	Mm
		1208119 PCGF1_MOUSE (2-229): 5.71e-62: 199: 35.47		RYBP_MOUSE (1-228): 1.71e-61: 193: 99.12
+	Hs
		1233178 PCGF1_HUMAN (2-229): 5.96e-62: 199: 36.33		RYBP_HUMAN (1-228): 2.79e-61: 193: 100.00
+	Mm
		1208122 PCGF6_MOUSE (2-235): 3.79e-60: 198: 35.54		RYBP_MOUSE (1-228): 1.71e-61: 193: 99.12
+	Hs
		1222219 PCGF6_HUMAN (2-235): 2.13e-61: 201: 35.12		YAF2_HUMAN (3-227): 3.24e-55: 176: 52.89
+	Hs
		1197570 PCGF5_HUMAN (1-228): 9.27e-56: 183: 30.44		RYBP_HUMAN (1-228): 2.79e-61: 193: 100.00
+	Hs
		1222217 PCGF1_HUMAN (2-229): 5.96e-62: 199: 36.33		YAF2_HUMAN (3-227): 3.24e-55: 176: 52.89
+	Hs
		585013 RO52_HUMAN (5-198): 5.75e-52: 180: 18.78		RYBP_HUMAN (1-228): 2.79e-61: 193: 100.00
+	Mm
		1208123 RING2_MOUSE (7-227): 5.77e-50: 171: 16.61		RYBP_MOUSE (1-228): 1.71e-61: 193: 99.12
+	Hs
		1197569 PCGF5_HUMAN (1-228): 9.27e-56: 183: 30.44		YAF2_HUMAN (3-227): 3.24e-55: 176: 52.89
+	Dm
		1374687 Q9VV77_DROME (3-229): 2.77e-68: 214: 36.80		Q9W215_DROME (3-197): 3.06e-42: 142: 37.95
+	Hs
		1019331 TRI26_HUMAN (5-210): 1e-49: 175: 16.59		YAF2_HUMAN (3-227): 3.24e-55: 176: 52.89
+	Dm
		728817 PSC_DROME (3-240): 3.98e-55: 195: 41.91		Q9W215_DROME (3-197): 3.06e-42: 142: 37.95
+	Dm
		627173 SUZ2_DROME (1-227): 6e-48: 174: 32.76		Q9W215_DROME (3-197): 3.06e-42: 142: 37.95