HitPredict

Interactor 1: BMI1 (P35226)
Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)
Gene: BMI1

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	26468281
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling GO:1990841 - promoter-specific chromatin binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 326 Hs			1 488
+	Hs
		1270421 PCGF6_HUMAN (2-235): 2.13e-61: 201: 35.12		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1270400 RING2_HUMAN (7-227): 8.37e-50: 170: 16.61		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Mm
		936425 RING2_MOUSE (7-227): 5.77e-50: 171: 16.61		HDAC2_MOUSE (1-488): 0: 704: 99.39
+	Hs
		1038684 PCGF6_HUMAN (2-235): 2.13e-61: 201: 35.12		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1270373 CHFR_HUMAN (8-168): 2.7e-31: 125: 19.14		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		584952 RO52_HUMAN (5-198): 5.75e-52: 180: 18.78		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1038656 RING2_HUMAN (7-227): 8.37e-50: 170: 16.61		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1038622 CHFR_HUMAN (8-168): 2.7e-31: 125: 19.14		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		987966 RING1_HUMAN (7-115): 2.38e-30: 120: 25.46		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		585087 RO52_HUMAN (5-198): 5.75e-52: 180: 18.78		HDAC6_HUMAN (11-363): 6.94e-102: 332: 24.04