Protein: MTCL2
Microtubule cross-linking factor 2 (SOGA family member 1) (Suppressor of glucose by autophagy) (Suppressor of glucose, autophagy-associated protein 1) [Cleaved into: N-terminal form; C-terminal 80 kDa form (80-kDa SOGA fragment)]

Gene: MTCL2
Organism: Homo sapiens
Interactions: 110
UniProt ID: O94964

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005615 - extracellular space
GO:0005874 - microtubule
GO:0007059 - chromosome segregation
GO:0008286 - insulin receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

322818

DYL1
Dynein light chain 1, cytoplasmic

4

7

High-throughput

0.697

High

322859

TSNAX
Translin-associated protein X

6

1

High-throughput

0.672

High

322804

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

3

6

High-throughput

0.662

High

322817

1433Z
14-3-3 protein zeta/delta

3

20

High-throughput

0.656

High

322821

1433F
14-3-3 protein eta

3

20

High-throughput

0.650

High

322854

DYL2
Dynein light chain 2, cytoplasmic

3

7

High-throughput

0.650

High

322803

MARK3
MAP/microtubule affinity-regulating kinase 3

2

10

High-throughput

0.628

High

322863

LZTS2
Leucine zipper putative tumor suppressor 2

2

20

High-throughput

0.628

High

322805

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.611

High

322815

1433G
14-3-3 protein gamma

2

20

High-throughput

0.611

High

322816

1433E
14-3-3 protein epsilon

2

6

High-throughput

0.611

High

322867

RNF41
E3 ubiquitin-protein ligase NRDP1

3

18

Small-scale

0.609

High

322875

ZN219
Zinc finger protein 219

3

5

High-throughput

0.609

High

69752

ZN785
Zinc finger protein 785

2

6

High-throughput

0.574

High

171820

ZN263
Zinc finger protein 263

2

5

High-throughput

0.574

High

322830

ZN169
Zinc finger protein 169

2

1

High-throughput

0.574

High

322841

MARK2
Serine/threonine-protein kinase MARK2

2

16

High-throughput

0.574

High

154925

BHE40
Class E basic helix-loop-helix protein 40

2

3

High-throughput

0.553

High

286608

STX11
Syntaxin-11

2

6

High-throughput

0.553

High

322799

ZNF20
Zinc finger protein 20

2

5

High-throughput

0.553

High

322835

F161A
Protein FAM161A

2

1

High-throughput

0.553

High

322838

EFHC2
EF-hand domain-containing family member C2

2

4

High-throughput

0.553

High

322842

NECA2
N-terminal EF-hand calcium-binding protein 2

2

1

High-throughput

0.553

High

322849

HDAC7
Histone deacetylase 7

2

20

High-throughput

0.553

High

322857

ASPP1
Apoptosis-stimulating of p53 protein 1

2

10

High-throughput

0.553

High

322876

TFP11
Tuftelin-interacting protein 11

2

1

High-throughput

0.553

High

322882

LZTS1
Leucine zipper putative tumor suppressor 1

2

20

High-throughput

0.553

High

322883

AMOL2
Angiomotin-like protein 2

2

20

High-throughput

0.553

High

322879

PNMA2
Paraneoplastic antigen Ma2

2

6

High-throughput

0.549

High

322819

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

9

High-throughput

0.536

High

322828

MAP7
Ensconsin

1

20

High-throughput

0.536

High

322847

COP1
E3 ubiquitin-protein ligase COP1

1

20

High-throughput

0.536

High

322858

MARK4
MAP/microtubule affinity-regulating kinase 4

1

16

High-throughput

0.536

High

322870

PKHA5
Pleckstrin homology domain-containing family A member 5

1

20

High-throughput

0.494

High

140694

NOP56
Nucleolar protein 56

1

4

High-throughput

0.489

High

158389

RFXK
DNA-binding protein RFXANK

1

7

Small-scale

0.489

High

322794

JUN
Transcription factor Jun

1

6

High-throughput

0.489

High

322798

GLI4
Zinc finger protein GLI4

1

4

High-throughput

0.489

High

322800

ZNF26
Zinc finger protein 26

1

2

High-throughput

0.489

High

322829

ZN460
Zinc finger protein 460

1

2

High-throughput

0.489

High

322834

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

1

5

High-throughput

0.489

High

322843

LDHD
Probable D-lactate dehydrogenase, mitochondrial

1

3

High-throughput

0.489

High

322845

ZN584
Zinc finger protein 584

1

1

High-throughput

0.489

High

322853

ZN689
Zinc finger protein 689

1

4

High-throughput

0.489

High

322860

AKAP9
A-kinase anchor protein 9

1

20

High-throughput

0.489

High

322868

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.489

High

322869

ANRA2
Ankyrin repeat family A protein 2

1

12

Small-scale

0.489

High

322884

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

1

High-throughput

0.489

High

163877

NDC80
Kinetochore protein NDC80 homolog

1

19

High-throughput

0.479

High

222599

PRC1
Protein regulator of cytokinesis 1

1

12

High-throughput

0.479

High

322791

LATS1
Serine/threonine-protein kinase LATS1

1

20

High-throughput

0.479

High

322792

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

15

High-throughput

0.479

High

322795

K2C8
Keratin, type II cytoskeletal 8

1

6

High-throughput

0.479

High

322796

PROF1
Profilin-1

1

2

High-throughput

0.479

High

322797

VIME
Vimentin

1

20

High-throughput

0.479

High

322802

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

322806

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

322810

GSK3A
Glycogen synthase kinase-3 alpha

1

20

High-throughput

0.479

High

322811

GSK3B
Glycogen synthase kinase-3 beta

1

20

High-throughput

0.479

High

322814

ARP3
Actin-related protein 3

1

20

High-throughput

0.479

High

322820

KIF23
Kinesin-like protein KIF23

1

16

High-throughput

0.479

High

322825

CUL3
Cullin-3

1

15

High-throughput

0.479

High

322826

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

20

High-throughput

0.479

High

322827

DCTN1
Dynactin subunit 1

1

20

High-throughput

0.479

High

322832

KIF14
Kinesin-like protein KIF14

1

18

High-throughput

0.479

High

322833

EEA1
Early endosome antigen 1

1

20

High-throughput

0.479

High

322846

SIR6
NAD-dependent protein deacylase sirtuin-6

1

9

High-throughput

0.479

High

322848

DYH5
Dynein axonemal heavy chain 5

1

14

High-throughput

0.479

High

322855

AURKB
Aurora kinase B

1

20

High-throughput

0.479

High

322872

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

7

High-throughput

0.479

High

322873

ANLN
Anillin

1

8

High-throughput

0.479

High

322878

CYH4
Cytohesin-4

1

5

High-throughput

0.479

High

322881

MARE3
Microtubule-associated protein RP/EB family member 3

1

5

High-throughput

0.479

High

322812

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

9

Small-scale

0.470

High

322823

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

14

Small-scale

0.470

High

322839

SCMC2
Mitochondrial adenyl nucleotide antiporter SLC25A25

1

6

High-throughput

0.470

High

322885

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

6

Small-scale

0.470

High

322851

RORB
Nuclear receptor ROR-beta

1

7

High-throughput

0.470

High

322801

VGFR1
Vascular endothelial growth factor receptor 1

1

7

Small-scale

0.445

High

322837

SGO1
Shugoshin 1

1

1

High-throughput

0.445

High

322836

Q58EY0
RAR related orphan receptor B isoform 1

1

7

High-throughput

0.439

High

137894

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

7

High-throughput

0.437

High

174472

TRI66
Tripartite motif-containing protein 66

1

20

High-throughput

0.437

High

193932

R113A
E3 ubiquitin-protein ligase RNF113A

1

2

High-throughput

0.437

High

246358

KDM1A
Lysine-specific histone demethylase 1A

1

8

High-throughput

0.437

High

322789

BRD1
Bromodomain-containing protein 1

1

11

High-throughput

0.437

High

322790

HERC2
E3 ubiquitin-protein ligase HERC2

1

13

High-throughput

0.437

High

322793

NTRK1
High affinity nerve growth factor receptor

1

17

High-throughput

0.437

High

322808

SOX2
Transcription factor SOX-2

1

10

High-throughput

0.437

High

322809

PAXI
Paxillin

1

14

High-throughput

0.437

High

322813

DJB13
DnaJ homolog subfamily B member 13

1

3

High-throughput

0.437

High

322822

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

20

High-throughput

0.437

High

322824

SMAD4
Mothers against decapentaplegic homolog 4

1

1

High-throughput

0.437

High

322840

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.437

High

322850

ESR2
Estrogen receptor beta

1

19

High-throughput

0.437

High

322852

VP33A
Vacuolar protein sorting-associated protein 33A

1

4

High-throughput

0.437

High

322856

BORC6
BLOC-1-related complex subunit 6

1

1

High-throughput

0.437

High

322864

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

5

High-throughput

0.437

High

322865

CCDC8
Coiled-coil domain-containing protein 8

1

6

High-throughput

0.437

High

322866

VP33B
Vacuolar protein sorting-associated protein 33B

1

4

High-throughput

0.437

High

322871

TRI36
E3 ubiquitin-protein ligase TRIM36

1

20

High-throughput

0.437

High

322874

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

9

High-throughput

0.437

High

322877

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.437

High

322880

BRPF3
Bromodomain and PHD finger-containing protein 3

1

9

High-throughput

0.437

High

254693

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

4

High-throughput

0.407

High

322807

BMI1
Polycomb complex protein BMI-1

1

12

High-throughput

0.407

High

322862

CCD77
Coiled-coil domain-containing protein 77

1

0

High-throughput

0.279

Low

322861

JPH2
Junctophilin-2

1

0

High-throughput

0.269

Low

322844

NUTM1
NUT family member 1

1

0

High-throughput

0.251

Low

322831

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025