HitPredict

Interactor 1: PCGF2 (P35227)
Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144)
Gene: PCGF2

Interactor 2: BCOR (Q6W2J9)
BCL-6 corepressor (BCoR)
Gene: BCOR

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	26687479, 24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PUFD~RAWUL
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 344 Hs			1 1755
+	Hs
		717948 BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40		BCOR_HUMAN (1-1755): 0: 2385: 100.00
+	Hs
		1108510 PCGF3_HUMAN (4-230): 3.51e-66: 210: 33.48		BCOR_HUMAN (1-1755): 0: 2385: 100.00
+	Hs
		1167299 PCGF1_HUMAN (2-232): 1.01e-61: 199: 35.42		BCOR_HUMAN (1-1755): 0: 2385: 100.00
+	Hs
		1167302 PCGF6_HUMAN (2-227): 3.54e-58: 193: 35.47		BCOR_HUMAN (1-1755): 0: 2385: 100.00
+	Hs
		1167255 PCGF5_HUMAN (1-221): 5.43e-53: 177: 31.88		BCOR_HUMAN (1-1755): 0: 2385: 100.00
+	Hs
		1167292 RING2_HUMAN (4-234): 2.68e-45: 159: 17.49		BCOR_HUMAN (1-1755): 0: 2385: 100.00
+	Mm
		1208443 RING2_MOUSE (4-234): 2.19e-45: 159: 17.49		BCOR_MOUSE (1-1755): 0: 2352: 88.59
+	Hs
		718403 PCGF2_HUMAN (1-344): 8.96e-118: 345: 100.00		BCORL_HUMAN (1025-1743): 3.64e-88: 321: 34.63
+	Hs
		717904 BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40		BCORL_HUMAN (1025-1743): 3.64e-88: 321: 34.63
+	Hs
		718205 BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40		EHMT1_HUMAN (1226-1631): 1.56e-64: 244: 15.87
+	Hs
		1108508 PCGF3_HUMAN (4-230): 3.51e-66: 210: 33.48		BCORL_HUMAN (1025-1743): 3.64e-88: 321: 34.63
+	Hs
		1125899 PCGF1_HUMAN (2-232): 1.01e-61: 199: 35.42		BCORL_HUMAN (1025-1743): 3.64e-88: 321: 34.63
+	Hs
		1125901 PCGF6_HUMAN (2-227): 3.54e-58: 193: 35.47		BCORL_HUMAN (1025-1743): 3.64e-88: 321: 34.63
+	Hs
		1125882 PCGF5_HUMAN (1-221): 5.43e-53: 177: 31.88		BCORL_HUMAN (1025-1743): 3.64e-88: 321: 34.63
+	Hs
		1125897 RING2_HUMAN (4-234): 2.68e-45: 159: 17.49		BCORL_HUMAN (1025-1743): 3.64e-88: 321: 34.63
+	Hs
		1021448 RING2_HUMAN (4-234): 2.68e-45: 159: 17.49		ANK3_HUMAN (1206-1755): 3.54e-78: 290: 12.69
+	Mm
		1125432 RING2_MOUSE (4-234): 2.19e-45: 159: 17.49		EHMT1_MOUSE (1226-1635): 8.01e-66: 248: 15.31
+	Dm
		1214938 Q9VV77_DROME (4-230): 3.72e-58: 189: 34.19		Q8IQT4_DROME (1426-1621): 1.22e-54: 213: 42.50
+	Hs
		718131 BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40		MPP8_HUMAN (1012-1706): 1.51e-15: 84.9: 10.00
+	Hs
		1206042 PCGF6_HUMAN (2-227): 3.54e-58: 193: 35.47		MIB1_HUMAN (1313-1647): 8.4e-44: 176: 14.75