Protein: ARH40
Rho guanine nucleotide exchange factor 40 (Protein SOLO)

Gene: ARH40, ARHGEF40
Organism: Homo sapiens
Interactions: 71
UniProt ID: Q8TER5

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007411 - axon guidance

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

177395

ARHGB
Rho guanine nucleotide exchange factor 11

2

17

High-throughput

0.767

High

1353098

PKH4B
Pleckstrin homology domain-containing family G member 4B

2

14

High-throughput

0.737

High

572946

INSRR
Insulin receptor-related protein

1

20

High-throughput

0.691

High

1353101

LPAR4
Lysophosphatidic acid receptor 4

2

6

High-throughput

0.628

High

401194

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

8

High-throughput

0.618

High

581190

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

953579

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

955406

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

988551

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1254785

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.618

High

1353108

ARHGC
Rho guanine nucleotide exchange factor 12

1

18

High-throughput

0.618

High

1010450

GPSM2
G-protein-signaling modulator 2

2

0

High-throughput

0.580

High

332424

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

2

12

High-throughput

0.571

High

713421

SPB3
Serpin B3

2

1

High-throughput

0.571

High

729591

CASPE
Caspase-14

2

2

High-throughput

0.571

High

1036773

DSG1
Desmoglein-1

2

5

High-throughput

0.571

High

1207310

SPIN3
Spindlin-3

2

1

High-throughput

0.571

High

1227134

A16L1
Autophagy-related protein 16-1

2

10

High-throughput

0.571

High

1353095

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

2

2

High-throughput

0.571

High

1353103

SRRT
Serrate RNA effector molecule homolog

2

3

High-throughput

0.571

High

1353105

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

2

12

High-throughput

0.571

High

335881

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

2

0

High-throughput

0.547

High

1062271

TGM3
Protein-glutamine gamma-glutamyltransferase E

2

0

High-throughput

0.547

High

1136920

ABRX2
BRISC complex subunit Abraxas 2

2

0

High-throughput

0.547

High

1213788

KPRP
Keratinocyte proline-rich protein

2

0

High-throughput

0.547

High

1353100

MYCBP
c-Myc-binding protein

1

2

High-throughput

0.541

High

133287

P2Y10
Putative P2Y purinoceptor 10

1

7

High-throughput

0.536

High

718434

CD6
T-cell differentiation antigen CD6

1

4

High-throughput

0.536

High

956954

CXCR4
C-X-C chemokine receptor type 4

1

3

High-throughput

0.536

High

553021

PIP
Prolactin-inducible protein

2

1

High-throughput

0.521

High

671830

ZA2G
Zinc-alpha-2-glycoprotein

2

1

High-throughput

0.521

High

932919

P5CS
Delta-1-pyrroline-5-carboxylate synthase

2

3

High-throughput

0.521

High

1353097

DUS3L
tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like

2

1

High-throughput

0.521

High

1353104

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

2

7

High-throughput

0.521

High

1353110

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

2

4

High-throughput

0.521

High

1353111

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

2

2

High-throughput

0.521

High

391378

FRIL
Ferritin light chain

1

0

High-throughput

0.513

High

867996

GLR
Glucagon receptor

1

0

High-throughput

0.513

High

422700

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

74556

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

7

High-throughput

0.489

High

848536

MAGA8
Melanoma-associated antigen 8

1

3

High-throughput

0.489

High

1208312

SPXN2
Sperm protein associated with the nucleus on the X chromosome N2

1

4

High-throughput

0.489

High

1275354

H2BWT
Histone H2B type W-T

1

3

High-throughput

0.489

High

294078

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

412309

NTRK1
High affinity nerve growth factor receptor

1

18

High-throughput

0.479

High

872567

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

1045559

TF65
Transcription factor p65

1

4

High-throughput

0.479

High

1107956

SQSTM
Sequestosome-1

1

3

High-throughput

0.479

High

1353102

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

1

High-throughput

0.479

High

1353106

NEK6
Serine/threonine-protein kinase Nek6

1

4

High-throughput

0.479

High

1353109

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

567038

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

5

High-throughput

0.470

High

1249048

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1252907

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

191374

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

5

High-throughput

0.445

High

848807

MAGAA
Melanoma-associated antigen 10

1

3

High-throughput

0.445

High

372663

MYC
Myc proto-oncogene protein

1

13

High-throughput

0.437

High

472330

CFAH
Complement factor H

1

1

Small-scale

0.437

High

1250173

LRC31
Leucine-rich repeat-containing protein 31

1

1

High-throughput

0.437

High

1326007

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

1353107

S22AB
Solute carrier family 22 member 11

1

0

High-throughput

0.426

High

1208264

SPXN3
Sperm protein associated with the nucleus on the X chromosome N3

1

4

High-throughput

0.407

High

1258518

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

3

High-throughput

0.407

High

1278546

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

1

5

High-throughput

0.407

High

1332411

CBY2
Protein chibby homolog 2

1

0

High-throughput

0.299

High

302263

STC2
Stanniocalcin-2

1

0

High-throughput

0.282

High

643948

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.279

Low

342268

BRD1
Bromodomain-containing protein 1

1

0

High-throughput

0.249

Low

1353096

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.249

Low

631810

TKN1
Protachykinin-1

1

0

High-throughput

0.238

Low

1353099

PEO1
Twinkle mtDNA helicase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025