HitPredict

Interactor 1: PHB1 (P35232)
Prohibitin 1
Gene: PHB1

Interactor 2: RHEB (Q15382)
GTP-binding protein Rheb (Ras homolog enriched in brain) (EC 3.6.5.-)
Gene: RHEB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	27025967
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 272 Hs			1 184
+	Hs
		718708 PHB1_HUMAN (1-272): 7.06e-92: 274: 100.00		RB11A_HUMAN (4-180): 7.77e-76: 228: 29.78
+	Hs
		718677 PHB1_HUMAN (1-272): 7.06e-92: 274: 100.00		RAB2A_HUMAN (1-170): 4.79e-74: 223: 31.58
+	Hs
		914308 PHB2_HUMAN (6-267): 1.38e-85: 259: 50.57		RB11A_HUMAN (4-180): 7.77e-76: 228: 29.78
+	Hs
		895239 PHB2_HUMAN (6-267): 1.38e-85: 259: 50.57		RAB2A_HUMAN (1-170): 4.79e-74: 223: 31.58
+	Dm
		185672 Q0E924_DROME (24-267): 1.92e-80: 246: 52.05		O18335_DROME (4-179): 3.42e-73: 221: 29.94
+	Hs
		646158 STOM_HUMAN (1-265): 6.57e-68: 213: 17.91		RAB8A_HUMAN (7-179): 4.93e-85: 251: 29.05
+	Hs
		646159 STOM_HUMAN (1-265): 6.57e-68: 213: 17.91		RAB2A_HUMAN (1-170): 4.79e-74: 223: 31.58
+	Dm
		185509 Q9VWL0_DROME (4-266): 1.77e-65: 209: 21.05		O18332_DROME (4-183): 2.38e-74: 223: 27.17
+	Dm
		185571 Q9VWL0_DROME (4-266): 1.77e-65: 209: 21.05		RAB2_DROME (1-170): 7.86e-73: 220: 30.99
+	Hs
		73286 B4E2V5_HUMAN (34-265): 4.89e-57: 184: 19.57		RAB2A_HUMAN (1-170): 4.79e-74: 223: 31.58
+	Sc
		350776 PHB1_YEAST (2-264): 1.98e-82: 251: 53.99		RAS1_YEAST (19-164): 7.84e-31: 115: 43.15
+	Dm
		442982 Q9VWL0_DROME (4-266): 1.77e-65: 209: 21.05		RAP1_DROME (5-164): 6.2e-37: 127: 40.00
+	Dm
		332237 Q9VWL0_DROME (4-266): 1.77e-65: 209: 21.05		O96692_DROME (19-166): 1.07e-30: 112: 38.51