Protein: LSM5
U6 snRNA-associated Sm-like protein LSm5

Gene: LSM5
Organism: Homo sapiens
Interactions: 63
UniProt ID: Q9Y4Y9

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005688 - U6 snRNP

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

974349

LSM6
U6 snRNA-associated Sm-like protein LSm6

10

20

High-throughput

0.978

High

1460920

LSM7
U6 snRNA-associated Sm-like protein LSm7

9

20

High-throughput

0.976

High

974093

RUXF
Small nuclear ribonucleoprotein F

8

20

High-throughput

0.975

High

974300

LSM3
U6 snRNA-associated Sm-like protein LSm3

6

20

High-throughput

0.948

High

973857

RUXE
Small nuclear ribonucleoprotein E

5

14

High-throughput

0.925

High

1491471

LSM4
U6 snRNA-associated Sm-like protein LSm4

4

20

High-throughput

0.892

High

178059

LSM1
U6 snRNA-associated Sm-like protein LSm1

2

20

High-throughput

0.811

High

215216

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

2

9

High-throughput

0.811

High

344582

LSM8
U6 snRNA-associated Sm-like protein LSm8

2

20

High-throughput

0.811

High

974704

SMD2
Small nuclear ribonucleoprotein Sm D2

2

20

High-throughput

0.811

High

1137208

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

2

20

High-throughput

0.811

High

1287162

PATL1
Protein PAT1 homolog 1

2

8

High-throughput

0.811

High

1491048

LSM2
U6 snRNA-associated Sm-like protein LSm2

2

20

High-throughput

0.811

High

480365

RU1C
U1 small nuclear ribonucleoprotein C

1

5

High-throughput

0.691

High

574532

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

16

High-throughput

0.691

High

974877

SMD3
Small nuclear ribonucleoprotein Sm D3

1

20

High-throughput

0.691

High

991276

RSMN
Small nuclear ribonucleoprotein-associated protein N

1

16

High-throughput

0.691

High

1271937

MEPCE
7SK snRNA methylphosphate capping enzyme

3

7

High-throughput

0.667

High

209360

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

2

13

High-throughput

0.628

High

407739

S100B
Protein S100-B

2

1

High-throughput

0.628

High

1327486

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

2

10

High-throughput

0.628

High

1332975

ZN511
Zinc finger protein 511

2

2

High-throughput

0.628

High

1413435

RBM42
RNA-binding protein 42

2

7

High-throughput

0.628

High

1434919

STPAP
Speckle targeted PIP5K1A-regulated poly(A) polymerase

2

5

High-throughput

0.628

High

1453885

AKA7G
A-kinase anchor protein 7 isoform gamma

2

10

High-throughput

0.611

High

1386916

DDT4L
DNA damage-inducible transcript 4-like protein

2

3

High-throughput

0.606

High

1490501

POLH
DNA polymerase eta

2

0

High-throughput

0.602

High

975595

TBPL1
TATA box-binding protein-like 1

2

0

High-throughput

0.580

High

1433391

PLK3
Serine/threonine-protein kinase PLK3

2

0

High-throughput

0.580

High

1387320

TMCO6
Transmembrane and coiled-coil domain-containing protein 6

2

1

High-throughput

0.574

High

352656

TCL1B
T-cell leukemia/lymphoma protein 1B

2

3

High-throughput

0.553

High

212354

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

5

High-throughput

0.536

High

321706

PRP6
Pre-mRNA-processing factor 6

1

20

High-throughput

0.536

High

483279

CLCA
Clathrin light chain A

1

2

High-throughput

0.536

High

844134

HD
Huntingtin

1

1

High-throughput

0.536

High

938428

NH2L1
NHP2-like protein 1

1

4

High-throughput

0.536

High

1109254

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

3

High-throughput

0.536

High

1161281

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.536

High

1358229

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

4

High-throughput

0.536

High

1359965

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

8

High-throughput

0.536

High

1414635

DDX23
Probable ATP-dependent RNA helicase DDX23

1

6

High-throughput

0.536

High

1120411

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

2

High-throughput

0.508

High

1447249

EXOS5
Exosome complex component RRP46

1

7

High-throughput

0.508

High

211457

RFOX2
RNA binding protein fox-1 homolog 2

1

2

High-throughput

0.481

High

1259180

LARP4
La-related protein 4

1

7

High-throughput

0.481

High

1329146

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

1

High-throughput

0.481

High

1400105

QKI
KH domain-containing RNA-binding protein QKI

1

4

High-throughput

0.481

High

607267

CEBPB
CCAAT/enhancer-binding protein beta

1

7

High-throughput

0.479

High

718858

CCND2
G1/S-specific cyclin-D2

1

1

Small-scale

0.479

High

965371

WDR5
WD repeat-containing protein 5

1

14

High-throughput

0.479

High

980606

H4
Histone H4

1

4

High-throughput

0.479

High

1290861

ZCH18
Zinc finger CCCH domain-containing protein 18

1

5

High-throughput

0.479

High

1459447

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1206586

PRC2B
Protein PRRC2B

1

0

High-throughput

0.460

High

1217854

PR38B
Pre-mRNA-splicing factor 38B

1

0

High-throughput

0.460

High

348012

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

1397601

CI072
Guanine nucleotide exchange factor C9orf72

1

0

Small-scale

0.426

High

887381

CEBPA
CCAAT/enhancer-binding protein alpha

1

7

High-throughput

0.408

High

224432

AKA7A
A-kinase anchor protein 7 isoforms alpha and beta

1

10

High-throughput

0.407

High

1333822

RDH13
Retinol dehydrogenase 13

2

0

High-throughput

0.328

High

1402434

HPLN3
Hyaluronan and proteoglycan link protein 3

2

0

High-throughput

0.328

High

1253258

SMI10
Sperm-associated microtubule inner protein 10

2

0

High-throughput

0.316

High

1335799

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025