HitPredict

Interactor 1: CCND3 (P30281)
G1/S-specific cyclin-D3
Gene: CCND3

Interactor 2: CDK5 (Q00535)
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
Gene: CDK5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.973

Property	Details
Experiments	26186194, 28514442, 32296183, 33961781, 34591612, 23602568, 23455922, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, validated two hybrid, two hybrid array, two hybrid prey pooling approach, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0004693 - cyclin-dependent protein serine/threonine kinase activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm and 2 others more... GO:0005829 - cytosol GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 292 Hs			1 292
+	Hs
		664638 CCND1_HUMAN (2-292): 1.66e-100: 298: 51.86		CDK2_HUMAN (1-292): 7.63e-142: 402: 59.39
+	Hs
		664708 CCND1_HUMAN (2-292): 1.66e-100: 298: 51.86		CDK3_HUMAN (1-291): 1.01e-139: 397: 61.30
+	Hs
		664710 CCND1_HUMAN (2-292): 1.66e-100: 298: 51.86		CDK5_HUMAN (1-292): 1.13e-137: 391: 100.00
+	Hs
		443185 CCND1_HUMAN (2-292): 1.66e-100: 298: 51.86		CDK1_HUMAN (1-289): 2.07e-133: 381: 56.01
+	At
		663899 CCA11_ARATH (1-287): 2.16e-98: 298: 23.10		CDKA1_ARATH (1-289): 3.89e-133: 380: 55.82
+	At
		663898 CCA32_ARATH (3-287): 5.55e-99: 296: 21.72		CDKA1_ARATH (1-289): 3.89e-133: 380: 55.82
+	At
		663906 CCA31_ARATH (10-292): 6.49e-97: 291: 21.95		CDKA1_ARATH (1-289): 3.89e-133: 380: 55.82
+	At
		663871 CCA21_ARATH (2-280): 1.57e-95: 290: 24.47		CDKA1_ARATH (1-289): 3.89e-133: 380: 55.82
+	At
		1421873 CCA32_ARATH (3-287): 5.55e-99: 296: 21.72		CDKD1_ARATH (2-292): 2.51e-128: 372: 49.14
+	At
		1421974 CCA11_ARATH (1-287): 2.16e-98: 298: 23.10		CDKD3_ARATH (2-292): 4e-125: 363: 47.77
+	At
		1421874 CCA32_ARATH (3-287): 5.55e-99: 296: 21.72		CDKD3_ARATH (2-292): 4e-125: 363: 47.77
+	At
		1426563 CCA31_ARATH (10-292): 6.49e-97: 291: 21.95		CDKD3_ARATH (2-292): 4e-125: 363: 47.77
+	At
		1320095 CCA11_ARATH (1-287): 2.16e-98: 298: 23.10		CKB21_ARATH (1-290): 8.03e-122: 352: 48.00
+	At
		1180612 CCA31_ARATH (10-292): 6.49e-97: 291: 21.95		CKB12_ARATH (1-289): 9.69e-124: 357: 50.97
+	At
		1180595 CCA21_ARATH (2-280): 1.57e-95: 290: 24.47		CKB12_ARATH (1-289): 9.69e-124: 357: 50.97
+	At
		683009 CCA11_ARATH (1-287): 2.16e-98: 298: 23.10		CKB11_ARATH (1-289): 1.96e-120: 349: 50.98
+	At
		1320098 CCA31_ARATH (10-292): 6.49e-97: 291: 21.95		CKB21_ARATH (1-290): 8.03e-122: 352: 48.00
+	At
		1184321 CCA21_ARATH (2-280): 1.57e-95: 290: 24.47		CKB21_ARATH (1-290): 8.03e-122: 352: 48.00
+	At
		683016 CCA31_ARATH (10-292): 6.49e-97: 291: 21.95		CKB11_ARATH (1-289): 1.96e-120: 349: 50.98
+	At
		682995 CCA21_ARATH (2-280): 1.57e-95: 290: 24.47		CKB11_ARATH (1-289): 1.96e-120: 349: 50.98