HitPredict

Interactor 1: PTN11 (P35235)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2)
Gene: Ptpn11

Interactor 2: LIRB3 (P97484)
Leukocyte immunoglobulin-like receptor subfamily B member 3 (LIR-3) (Leukocyte immunoglobulin-like receptor 3) (Cell-surface glycoprotein p91) (Paired immunoglobulin-like receptor B) (PIR-B)
Gene: Lilrb3

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.50	0.641

Property	Details
Experiments	22660330, 11812650, 20398663, 18316626, 24052308
Identification Methods	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 593 Mm			1 841
+	Mm
		665982 PTN6_MOUSE (6-583): 0: 544: 55.94		LIRB3_MOUSE (1-841): 2.05e-169: 513: 100.00
+	Mm
		719316 PTN11_MOUSE (1-593): 0: 605: 100.00		Q8K4V6_MOUSE (1-695): 1.54e-128: 402: 95.98
+	Hs
		798232 PTN11_HUMAN (1-593): 0: 606: 99.49		KI3L1_HUMAN (419-834): 9.5e-72: 244: 23.46
+	Hs
		986023 PTN11_HUMAN (1-593): 0: 606: 99.49		KI2L4_HUMAN (119-335): 4.25e-53: 191: 26.58
+	Hs
		665821 PTN6_HUMAN (6-593): 0: 540: 54.79		KI3L1_HUMAN (419-834): 9.5e-72: 244: 23.46
+	Hs
		798184 PTN11_HUMAN (1-593): 0: 606: 99.49		KI2L3_HUMAN (520-832): 1.61e-42: 160: 21.70
+	Hs
		798139 PTN11_HUMAN (1-593): 0: 606: 99.49		KI2L1_HUMAN (520-834): 1.06e-37: 146: 21.63
+	Hs
		985950 PTN11_HUMAN (1-593): 0: 606: 99.49		PTK7_HUMAN (318-841): 8.38e-35: 145: 11.26
+	Mm
		719307 PTN11_MOUSE (1-593): 0: 605: 100.00		LRB4A_MOUSE (116-324): 1.64e-27: 116: 24.07
+	Hs
		557450 PTN11_HUMAN (1-593): 0: 606: 99.49		PECA1_HUMAN (35-617): 1.09e-20: 99.8: 17.31
+	Hs
		665820 PTN6_HUMAN (6-593): 0: 540: 54.79		KI2L3_HUMAN (520-832): 1.61e-42: 160: 21.70
+	Hs
		665819 PTN6_HUMAN (6-593): 0: 540: 54.79		KI2L1_HUMAN (520-834): 1.06e-37: 146: 21.63
+	Hs
		665883 PTN6_HUMAN (6-593): 0: 540: 54.79		PTK7_HUMAN (318-841): 8.38e-35: 145: 11.26
+	Hs
		985972 PTN11_HUMAN (1-593): 0: 606: 99.49		LAIR1_HUMAN (122-234): 6.64e-11: 65.9: 28.07
+	Mm
		665991 PTN6_MOUSE (6-583): 0: 544: 55.94		LRB4A_MOUSE (116-324): 1.64e-27: 116: 24.07
+	Mm
		665976 PTN6_MOUSE (6-583): 0: 544: 55.94		CD22_MOUSE (2-225): 8.65e-23: 106: 16.09
+	Hs
		252776 PTN6_HUMAN (6-593): 0: 540: 54.79		LIRB3_HUMAN (21-228): 1.37e-22: 105: 32.86
+	Hs
		557436 PTN6_HUMAN (6-593): 0: 540: 54.79		PECA1_HUMAN (35-617): 1.09e-20: 99.8: 17.31
+	Hs
		590601 PTN6_HUMAN (6-593): 0: 540: 54.79		CD22_HUMAN (356-660): 2.07e-16: 86.1: 16.03
+	Mm
		665995 PTN6_MOUSE (6-583): 0: 544: 55.94		LAIR1_MOUSE (1-176): 3.31e-12: 69.4: 25.77