HitPredict

Interactor 1: PE2R4 (P35408)
Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)
Gene: PTGER4

Interactor 2: ARRB1 (P49407)
Beta-arrestin-1 (Arrestin beta-1) (Non-visual arrestin-2)
Gene: ARRB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	16432186
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	7tm_1~Arrestin_C, 7tm_1~Arrestin_N
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 488 Hs			1 418
+	Hs
		793171 PE2R2_HUMAN (20-370): 1.17e-79: 253: 30.96		ARRB1_HUMAN (1-418): 0: 716: 100.00
+	Hs
		827197 MTR1L_HUMAN (7-477): 3.01e-76: 252: 15.09		ARRB1_HUMAN (1-418): 0: 716: 100.00
+	Hs
		441649 ADRB1_HUMAN (1-365): 1.96e-74: 244: 17.90		ARRB1_HUMAN (1-418): 0: 716: 100.00
+	Hs
		208444 OX1R_HUMAN (34-396): 8.09e-69: 228: 14.48		ARRB1_HUMAN (1-418): 0: 716: 100.00
+	Hs
		685812 PE2R4_HUMAN (1-488): 1.97e-100: 312: 100.00		ARRB2_HUMAN (1-407): 0: 626: 76.15
+	Hs
		428933 ADRB2_HUMAN (13-352): 1.09e-78: 253: 16.47		ARRB2_HUMAN (1-407): 0: 626: 76.15
+	Hs
		685831 PE2R2_HUMAN (20-370): 1.17e-79: 253: 30.96		ARRB2_HUMAN (1-407): 0: 626: 76.15
+	Hs
		656989 5HT2A_HUMAN (1-395): 6.05e-76: 248: 16.75		ARRB2_HUMAN (1-407): 0: 626: 76.15
+	Rn
		663954 Q8VBU7_RAT (13-393): 2.08e-80: 257: 16.54		ARRB2_RAT (1-407): 0: 616: 75.00
+	Hs
		441648 ADRB1_HUMAN (1-365): 1.96e-74: 244: 17.90		ARRB2_HUMAN (1-407): 0: 626: 76.15
+	Hs
		600867 TA2R_HUMAN (7-340): 4.83e-72: 233: 23.70		ARRB2_HUMAN (1-407): 0: 626: 76.15
+	Hs
		208441 OX1R_HUMAN (34-396): 8.09e-69: 228: 14.48		ARRB2_HUMAN (1-407): 0: 626: 76.15