HitPredict

Interactor 1: FBN2 (P35556)
Fibrillin-2 [Cleaved into: Placensin]
Gene: FBN2

Interactor 2: NET5 (Q8WTR8)
Netrin-5 (Netrin-1-like protein)
Gene: NTN5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 2912 Hs			1 489
+	Hs
		724350 FBN1_HUMAN (1742-2819): 1.44e-54: 214: 21.20		NET5_HUMAN (1-489): 1.06e-87: 278: 100.00
+	Hs
		1231788 LTBP4_HUMAN (5-896): 8.44e-35: 149: 16.19		NET5_HUMAN (1-489): 1.06e-87: 278: 100.00
+	Hs
		1059024 LTBP1_HUMAN (1-812): 7.93e-29: 129: 16.35		NET5_HUMAN (1-489): 1.06e-87: 278: 100.00
+	Hs
		1259461 NOTC3_HUMAN (8-486): 1.74e-24: 115: 14.18		NET5_HUMAN (1-489): 1.06e-87: 278: 100.00
+	Hs
		1259462 JAG2_HUMAN (2-291): 1.2e-19: 99.3: 17.43		NET5_HUMAN (1-489): 1.06e-87: 278: 100.00
+	Hs
		804299 NOTC1_HUMAN (2519-2834): 2.3e-19: 98.6: 14.12		NET5_HUMAN (1-489): 1.06e-87: 278: 100.00
+	Dm
		422762 NOTCH_DROME (5-722): 2.33e-41: 171: 15.01		NETB_DROME (143-472): 9.84e-53: 192: 31.10
+	Hs
		980475 NOTC2_HUMAN (2615-2838): 8.38e-12: 73.9: 14.04		NET5_HUMAN (1-489): 1.06e-87: 278: 100.00
+	Hs
		1259460 FBLN5_HUMAN (1500-1764): 6.93e-10: 66.2: 29.23		NET5_HUMAN (1-489): 1.06e-87: 278: 100.00
+	Hs
		317789 NOTC2_HUMAN (2615-2838): 8.38e-12: 73.9: 14.04		NET1_HUMAN (58-476): 4.08e-73: 244: 38.62
+	Dm
		422715 NOTCH_DROME (5-722): 2.33e-41: 171: 15.01		LAMC1_DROME (20-327): 1.21e-27: 119: 15.82
+	Dm
		484988 CRB_DROME (368-693): 3.17e-12: 75.1: 14.89		NETB_DROME (143-472): 9.84e-53: 192: 31.10
+	Dm
		90684 NOTCH_DROME (5-722): 2.33e-41: 171: 15.01		E1JHA6_DROME (120-460): 4.09e-13: 74.5: 10.63
+	Dm
		422742 NOTCH_DROME (5-722): 2.33e-41: 171: 15.01		LAMA_DROME (4-222): 2.52e-11: 68.7: 11.71
+	Hs
		877404 NOTC2_HUMAN (2615-2838): 8.38e-12: 73.9: 14.04		LAMB2_HUMAN (89-313): 5.5e-20: 96: 17.80
+	Hs
		172655 FBLN2_HUMAN (93-427): 2.59e-20: 101: 24.48		LAMA5_HUMAN (2-279): 1.23e-10: 66.4: 14.13
+	Hs
		631059 FBLN2_HUMAN (93-427): 2.59e-20: 101: 24.48		LAMA1_HUMAN (7-221): 2.35e-10: 65.6: 11.84
+	Hs
		877405 FBLN3_HUMAN (1517-1737): 9.42e-10: 65.9: 31.39		LAMB2_HUMAN (89-313): 5.5e-20: 96: 17.80
+	Hs
		172715 FBLN5_HUMAN (1500-1764): 6.93e-10: 66.2: 29.23		LAMA5_HUMAN (2-279): 1.23e-10: 66.4: 14.13