HitPredict

Interactor 1: MYH10 (P35580)
Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB)
Gene: MYH10

Interactor 2: MYL6 (P60660)
Myosin light polypeptide 6 (17 kDa myosin light chain) (LC17) (Myosin light chain 3) (MLC-3) (Myosin light chain alkali 3) (Myosin light chain A3) (Smooth muscle and nonmuscle myosin light chain alkali 6)
Gene: MYL6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.718

Property	Details
Experiments	28514442, 24981860, 33961781, 35271311, 35235311
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000146 - microfilament motor activity GO:0005829 - cytosol GO:0016459 - myosin complex GO:0016460 - myosin II complex GO:0070062 - extracellular exosome
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1976 Hs			1 151
+	Ce
		104561 G5EBY3_CAEEL (23-1927): 0: 1312: 45.99		CALM_CAEEL (5-77): 2.09e-11: 59.8: 30.14
+	Hs
		409452 MYH10_HUMAN (1-1976): 0: 1106: 100.00		MYL1_HUMAN (3-150): 1.84e-56: 176: 74.32
+	Hs
		441666 MYH10_HUMAN (1-1976): 0: 1106: 100.00		MYL3_HUMAN (3-150): 2.39e-55: 173: 73.33
+	Hs
		538643 MYH10_HUMAN (1-1976): 0: 1106: 100.00		MYL6B_HUMAN (3-150): 2.63e-42: 141: 81.76
+	Hs
		441665 MYH9_HUMAN (877-1976): 1.43e-64: 246: 17.95		MYL3_HUMAN (3-150): 2.39e-55: 173: 73.33
+	Gg
		361265 MYH11_CHICK (930-1976): 1.37e-67: 256: 19.21		MYL6_CHICK (1-151): 1.02e-51: 162: 89.40
+	Hs
		728458 MYH11_HUMAN (805-1976): 1.82e-68: 259: 18.21		MYL6_HUMAN (1-151): 9.61e-42: 137: 100.00
+	Hs
		441674 MYH14_HUMAN (889-1974): 4.36e-57: 221: 18.29		MYL3_HUMAN (3-150): 2.39e-55: 173: 73.33
+	Dm
		870145 MYSN_DROME (985-1974): 1.71e-56: 219: 16.49		MLC2_DROME (1-151): 6.78e-55: 171: 53.64
+	Hs
		538642 MYH9_HUMAN (877-1976): 1.43e-64: 246: 17.95		MYL6B_HUMAN (3-150): 2.63e-42: 141: 81.76
+	Hs
		724737 MYH9_HUMAN (877-1976): 1.43e-64: 246: 17.95		MYL6_HUMAN (1-151): 9.61e-42: 137: 100.00
+	Hs
		538680 MYH14_HUMAN (889-1974): 4.36e-57: 221: 18.29		MYL6B_HUMAN (3-150): 2.63e-42: 141: 81.76
+	Hs
		891551 MYH14_HUMAN (889-1974): 4.36e-57: 221: 18.29		MYL6_HUMAN (1-151): 9.61e-42: 137: 100.00
+	Ce
		522310 MYO3_CAEEL (730-1820): 3.53e-59: 228: 16.90		MLE_CAEEL (12-151): 6.35e-36: 123: 46.43
+	Ce
		361125 MYO1_CAEEL (734-1731): 2.7e-55: 216: 17.00		MLE_CAEEL (12-151): 6.35e-36: 123: 46.43
+	Hs
		648467 MYH9_HUMAN (877-1976): 1.43e-64: 246: 17.95		CALL3_HUMAN (5-77): 1.25e-10: 57.9: 26.03
+	Ce
		361113 MYO4_CAEEL (732-1537): 3.32e-37: 156: 15.27		MLE_CAEEL (12-151): 6.35e-36: 123: 46.43