Protein: HXB5
Homeobox protein Hox-B5 (Homeobox protein HHO.C10) (Homeobox protein Hox-2A) (Homeobox protein Hu-1)

Gene: HXB5, HOXB5
Organism: Homo sapiens
Interactions: 112
UniProt ID: P09067

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001650 - fibrillar center

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

478307

HXC4
Homeobox protein Hox-C4

3

19

High-throughput

0.861

High

478660

PBX1
Pre-B-cell leukemia transcription factor 1

2

20

High-throughput

0.783

High

478661

PBX2
Pre-B-cell leukemia transcription factor 2

2

20

High-throughput

0.783

High

478721

PBX4
Pre-B-cell leukemia transcription factor 4

2

20

High-throughput

0.783

High

478659

TRI23
E3 ubiquitin-protein ligase TRIM23

3

2

High-throughput

0.675

High

478662

MAGAB
Melanoma-associated antigen 11

3

1

High-throughput

0.675

High

478668

CTBP2
C-terminal-binding protein 2

3

6

High-throughput

0.675

High

291191

NU155
Nuclear pore complex protein Nup155

3

1

High-throughput

0.667

High

462951

YES
Tyrosine-protein kinase Yes

3

10

High-throughput

0.667

High

463288

LYN
Tyrosine-protein kinase Lyn

3

10

High-throughput

0.667

High

478653

SRC
Proto-oncogene tyrosine-protein kinase Src

3

10

High-throughput

0.667

High

478683

EFR3A
Protein EFR3 homolog A

3

1

High-throughput

0.667

High

478701

CCNY
Cyclin-Y

3

3

High-throughput

0.667

High

478709

CTBL1
Beta-catenin-like protein 1

3

1

High-throughput

0.667

High

478713

SIR1
NAD-dependent protein deacetylase sirtuin-1

3

10

High-throughput

0.667

High

478735

SIR5
NAD-dependent protein deacylase sirtuin-5, mitochondrial

3

10

High-throughput

0.667

High

478741

EFR3B
Protein EFR3 homolog B

3

1

High-throughput

0.667

High

478691

Q6FHY5
MEOX2 protein

1

16

High-throughput

0.665

High

478655

H13
Histone H1.3

3

0

High-throughput

0.638

High

63166

VP37C
Vacuolar protein sorting-associated protein 37C

2

5

High-throughput

0.628

High

478682

CTBP1
C-terminal-binding protein 1

2

6

High-throughput

0.628

High

478666

MEOX2
Homeobox protein MOX-2

1

16

High-throughput

0.621

High

478663

NKX21
Homeobox protein Nkx-2.1

1

20

Small-scale

0.618

High

374350

RASH
GTPase HRas

2

3

High-throughput

0.611

High

440306

FYN
Tyrosine-protein kinase Fyn

2

10

High-throughput

0.611

High

478695

HDGR2
Hepatoma-derived growth factor-related protein 2

2

8

High-throughput

0.611

High

478702

NUP35
Nucleoporin NUP35

2

1

High-throughput

0.611

High

478712

VPP1
V-type proton ATPase 116 kDa subunit a 1

2

1

High-throughput

0.611

High

478715

TRI11
E3 ubiquitin-protein ligase TRIM11

2

13

High-throughput

0.611

High

478728

GBB4
Guanine nucleotide-binding protein subunit beta-4

2

2

High-throughput

0.611

High

478656

GNAZ
Guanine nucleotide-binding protein G(z) subunit alpha

3

4

High-throughput

0.609

High

478700

CCYL1
Cyclin-Y-like protein 1

3

3

High-throughput

0.609

High

217042

MS18B
Protein Mis18-beta

2

2

High-throughput

0.606

High

269145

HSF2B
Heat shock factor 2-binding protein

2

1

High-throughput

0.606

High

300285

KRT34
Keratin, type I cuticular Ha4

2

20

High-throughput

0.606

High

343726

LDOC1
Protein LDOC1

2

1

High-throughput

0.606

High

478654

TRI27
Zinc finger protein RFP

2

13

High-throughput

0.606

High

478669

KR106
Keratin-associated protein 10-6

2

20

High-throughput

0.606

High

478670

KR108
Keratin-associated protein 10-8

2

20

High-throughput

0.606

High

478675

KRA11
Keratin-associated protein 1-1

2

20

High-throughput

0.606

High

478676

TLE5
TLE family member 5

2

13

High-throughput

0.606

High

478679

TRAF2
TNF receptor-associated factor 2

2

20

High-throughput

0.606

High

478680

TRAF1
TNF receptor-associated factor 1

2

10

High-throughput

0.606

High

478681

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

2

3

High-throughput

0.606

High

478685

K1H1
Keratin, type I cuticular Ha1

2

20

High-throughput

0.606

High

478687

USH1G
pre-mRNA splicing regulator USH1G

2

20

High-throughput

0.606

High

478688

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

1

High-throughput

0.606

High

478689

PHF19
PHD finger protein 19

2

3

High-throughput

0.606

High

478690

MYOME
Myomegalin

2

1

High-throughput

0.606

High

478692

ZN774
Zinc finger protein 774

2

10

High-throughput

0.606

High

478699

ZN655
Zinc finger protein 655

2

4

High-throughput

0.606

High

478704

CEP70
Centrosomal protein of 70 kDa

2

1

High-throughput

0.606

High

478705

IKBD
NF-kappa-B inhibitor delta

2

20

High-throughput

0.606

High

478708

TEKT4
Tektin-4

2

5

High-throughput

0.606

High

478711

KIFA3
Kinesin-associated protein 3

2

1

High-throughput

0.606

High

478714

HOOK2
Protein Hook homolog 2

2

6

High-throughput

0.606

High

478718

TRIB3
Tribbles homolog 3

2

5

High-throughput

0.606

High

478719

TRAF4
TNF receptor-associated factor 4

2

19

High-throughput

0.606

High

478724

PRD14
PR domain zinc finger protein 14

2

13

High-throughput

0.606

High

478726

CARD9
Caspase recruitment domain-containing protein 9

2

3

High-throughput

0.606

High

478727

ZN552
Zinc finger protein 552

2

14

High-throughput

0.606

High

478729

Z286A
Zinc finger protein 286A

2

8

High-throughput

0.606

High

478731

HOME3
Homer protein homolog 3

2

10

High-throughput

0.606

High

478734

ASB6
Ankyrin repeat and SOCS box protein 6

2

20

High-throughput

0.606

High

478737

ZRAN1
Ubiquitin thioesterase ZRANB1

2

4

High-throughput

0.606

High

478742

AXIN2
Axin-2

2

8

High-throughput

0.606

High

292421

PALM
Paralemmin-1

2

0

High-throughput

0.585

High

64524

CC88B
Coiled-coil domain-containing protein 88B

2

0

High-throughput

0.580

High

478667

HAP1
Huntingtin-associated protein 1

2

0

High-throughput

0.580

High

478673

CSK2B
Casein kinase II subunit beta

2

0

High-throughput

0.580

High

478698

VPS52
Vacuolar protein sorting-associated protein 52 homolog

2

0

High-throughput

0.580

High

478730

ZC4H2
Zinc finger C4H2 domain-containing protein

2

0

High-throughput

0.580

High

370983

MYC
Myc proto-oncogene protein

1

8

High-throughput

0.575

High

478652

GNAO
Guanine nucleotide-binding protein G(o) subunit alpha

2

4

High-throughput

0.558

High

478665

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

2

4

High-throughput

0.558

High

478723

ULBP2
UL16-binding protein 2

2

3

High-throughput

0.558

High

65007

GG6L9
Golgin subfamily A member 6-like protein 9

2

7

High-throughput

0.553

High

70091

CRTP1
Cysteine-rich tail protein 1

2

5

High-throughput

0.553

High

478677

GOGA2
Golgin subfamily A member 2

2

6

High-throughput

0.553

High

478720

CNFN
Cornifelin

2

3

High-throughput

0.553

High

478722

TRI54
Tripartite motif-containing protein 54

2

18

High-throughput

0.553

High

478736

GOG6A
Golgin subfamily A member 6A

2

7

High-throughput

0.553

High

478738

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

20

High-throughput

0.553

High

478686

KRA63
Keratin-associated protein 6-3

1

4

High-throughput

0.515

High

478717

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

9

Small-scale

0.481

High

478739

CAPS1
Calcium-dependent secretion activator 1

1

3

High-throughput

0.481

High

359905

NB5R3
NADH-cytochrome b5 reductase 3

1

2

High-throughput

0.479

High

451103

NFL
Neurofilament light polypeptide

1

11

High-throughput

0.479

High

478664

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

4

High-throughput

0.479

High

478671

ACTB
Actin, cytoplasmic 1

1

1

High-throughput

0.479

High

478672

RAB2A
Ras-related protein Rab-2A

1

4

High-throughput

0.479

High

478674

KC1G2
Casein kinase I isoform gamma-2

1

5

High-throughput

0.479

High

478684

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

4

High-throughput

0.479

High

478732

RBM12
RNA-binding protein 12

1

1

High-throughput

0.479

High

60230

A2RRN7
CADPS protein

1

3

High-throughput

0.470

High

478657

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

0

High-throughput

0.458

High

478694

MEAK7
MTOR-associated protein MEAK7

1

0

High-throughput

0.458

High

478696

TBC26
TBC1 domain family member 26

1

5

High-throughput

0.439

High

478716

CC136
Coiled-coil domain-containing protein 136

1

2

High-throughput

0.439

High

478658

GNA11
Guanine nucleotide-binding protein subunit alpha-11

1

4

High-throughput

0.437

High

478743

VPP2
V-type proton ATPase 116 kDa subunit a 2

1

1

High-throughput

0.437

High

478678

CNTN1
Contactin-1

3

0

High-throughput

0.347

High

478733

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

3

0

High-throughput

0.347

High

478706

OCC1
Overexpressed in colon carcinoma 1 protein

2

0

High-throughput

0.328

High

478693

ERIC5
Glutamate-rich protein 5

2

0

High-throughput

0.318

High

478703

SVIP
Small VCP/p97-interacting protein

2

0

High-throughput

0.318

High

478697

TEX11
Testis-expressed protein 11

2

0

High-throughput

0.316

High

478725

ZMY12
Zinc finger MYND domain-containing protein 12

2

0

High-throughput

0.316

High

478744

PLXD1
Plexin-D1

2

0

High-throughput

0.316

High

478707

UBTD2
Ubiquitin domain-containing protein 2

1

0

High-throughput

0.279

Low

478710

ASM3B
Acid sphingomyelinase-like phosphodiesterase 3b

1

0

High-throughput

0.249

Low

478740

EPCR
Endothelial protein C receptor

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025