HitPredict

Interactor 1: ACTN2 (P35609)
Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein)
Gene: ACTN2

Interactor 2: ACTN2 (P35609)
Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein)
Gene: ACTN2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.85 1.00 0.923

The method score is based on:

Property Details
Experiments 25416956, 25502805, 31515488, 11101506, 9501083
Identification Methods two hybrid, two hybrid array, pull down, isothermal titration calorimetry, protein cross-linking with a bifunctional reagent
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains CH~CH, CH~EF-hand_7, CH~EFhand_Ca_insen, CH~Spectrin, EF-hand_7~EF-hand_7, EF-hand_7~EFhand_Ca_insen, EFhand_Ca_insen~EFhand_Ca_insen, EFhand_Ca_insen~Spectrin, Spectrin~Spectrin
Common GO terms GO:0005178 - integrin binding
GO:0005509 - calcium ion binding
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding
GO:0005576 - extracellular region
GO:0005829 - cytosol
and 45 others

more...
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 894
Hs

1 894
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+ Rn
+ Ce

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024