HitPredict

Interactor 1: ACTN2 (P35609)
Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein)
Gene: ACTN2

Interactor 2: NMDZ1 (Q05586)
Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1)
Gene: GRIN1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	16510730
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005509 - calcium ion binding GO:0042391 - regulation of membrane potential GO:0043197 - dendritic spine
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 894 Hs			1 938
+	Rn
		723638 ACTN1_RAT (8-894): 0: 660: 79.48		NMDZ1_RAT (1-938): 0: 936: 99.25
+	Mm
		723613 ACTN2_MOUSE (1-894): 0: 655: 99.22		NMDZ1_MOUSE (1-938): 0: 936: 99.04
+	Hs
		211568 ACTN4_HUMAN (18-894): 0: 619: 77.89		NMDZ1_HUMAN (1-938): 0: 935: 100.00
+	Hs
		725650 ACTN2_HUMAN (1-894): 0: 652: 100.00		NMDE2_HUMAN (4-938): 0: 661: 23.83
+	Mm
		963773 ACTN2_MOUSE (1-894): 0: 655: 99.22		NMDE2_MOUSE (4-938): 0: 654: 23.63
+	Rn
		585223 ACTN4_RAT (18-894): 0: 615: 77.44		GRIA4_RAT (4-888): 0: 691: 22.21
+	Mm
		723587 SPTB2_MOUSE (232-802): 1.8e-09: 63.9: 9.98		NMDZ1_MOUSE (1-938): 0: 936: 99.04
+	Rn
		585221 SPTN2_RAT (258-755): 4.1e-09: 62.8: 11.00		GRIA4_RAT (4-888): 0: 691: 22.21
+	Hs
		786728 SPTB2_HUMAN (232-802): 2.32e-09: 63.5: 9.98		GRIA2_HUMAN (5-856): 0: 661: 21.49