Protein: PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCase subunit alpha) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit alpha)

Gene: PCCA
Organism: Homo sapiens
Interactions: 132
UniProt ID: P05165

Gene Ontology (top 5):
GO:0004658 - propionyl-CoA carboxylase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

425760

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

5

18

Small-scale

0.932

High

425843

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

2

16

High-throughput

0.737

High

425812

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

2

1

High-throughput

0.628

High

425846

TTC1
Tetratricopeptide repeat protein 1

2

5

High-throughput

0.628

High

425764

PYC
Pyruvate carboxylase, mitochondrial

1

15

High-throughput

0.618

High

425799

ACACA
Acetyl-CoA carboxylase 1

1

16

High-throughput

0.618

High

425850

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

18

High-throughput

0.618

High

425810

SYRM
Probable arginine--tRNA ligase, mitochondrial

2

1

High-throughput

0.611

High

425771

CRCM
Colorectal mutant cancer protein

2

1

High-throughput

0.606

High

240481

PRKN
E3 ubiquitin-protein ligase parkin

2

9

High-throughput

0.584

High

425774

PML
Protein PML

2

10

High-throughput

0.584

High

425781

CCNF
Cyclin-F

2

5

High-throughput

0.584

High

275232

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

1

High-throughput

0.536

High

288212

KBL
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

1

1

High-throughput

0.536

High

425761

IFIT1
Antiviral innate immune response effector IFIT1

1

4

High-throughput

0.536

High

425772

KAD4
Adenylate kinase 4, mitochondrial

1

1

High-throughput

0.536

High

425782

PLPL4
Patatin-like phospholipase domain-containing protein 4

1

1

High-throughput

0.536

High

425785

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

2

High-throughput

0.536

High

425790

YBEY
Endoribonuclease YbeY

1

2

High-throughput

0.536

High

425814

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

1

High-throughput

0.536

High

425819

TLK2
Serine/threonine-protein kinase tousled-like 2

1

6

High-throughput

0.536

High

425836

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

2

High-throughput

0.536

High

425837

RT24
Small ribosomal subunit protein uS3m

1

1

High-throughput

0.536

High

425848

HDHD3
Haloacid dehalogenase-like hydrolase domain-containing protein 3

1

1

High-throughput

0.536

High

425849

MTG2
Mitochondrial ribosome-associated GTPase 2

1

2

High-throughput

0.536

High

425856

NPS3A
Protein NipSnap homolog 3A

1

3

High-throughput

0.536

High

425859

MRM2
rRNA methyltransferase 2, mitochondrial

1

1

High-throughput

0.536

High

425866

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

2

High-throughput

0.536

High

425867

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

5

High-throughput

0.536

High

425806

TAZ
Tafazzin

1

0

High-throughput

0.513

High

425839

NTAQ1
Protein N-terminal glutamine amidohydrolase

1

0

High-throughput

0.513

High

425841

IP6K3
Inositol hexakisphosphate kinase 3

1

0

High-throughput

0.513

High

425855

RM27
Large ribosomal subunit protein bL27m

1

0

High-throughput

0.513

High

425769

FPR1
fMet-Leu-Phe receptor

1

1

High-throughput

0.489

High

425825

PAF1
RNA polymerase II-associated factor 1 homolog

1

3

High-throughput

0.489

High

425835

TRI43
Tripartite motif-containing protein 43

1

2

High-throughput

0.489

High

425847

NAA38
N-alpha-acetyltransferase 38, NatC auxiliary subunit

1

1

High-throughput

0.489

High

122901

SGK1
Serine/threonine-protein kinase Sgk1

1

8

High-throughput

0.479

High

125143

LEG9
Galectin-9

1

6

High-throughput

0.479

High

125702

STXB3
Syntaxin-binding protein 3

1

1

High-throughput

0.479

High

176119

PER2
Period circadian protein homolog 2

1

4

Small-scale

0.479

High

246391

KDM1A
Lysine-specific histone demethylase 1A

1

4

High-throughput

0.479

High

317775

LTN1
E3 ubiquitin-protein ligase listerin

1

3

High-throughput

0.479

High

413006

P53
Cellular tumor antigen p53

1

5

Small-scale

0.479

High

425762

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

7

Small-scale

0.479

High

425763

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

425765

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

425766

LEG3
Galectin-3

1

6

Small-scale

0.479

High

425767

ARF4
ADP-ribosylation factor 4

1

10

High-throughput

0.479

High

425780

ARL1
ADP-ribosylation factor-like protein 1

1

11

High-throughput

0.479

High

425784

YAP1
Transcriptional coactivator YAP1

1

16

High-throughput

0.479

High

425791

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

6

Small-scale

0.479

High

425792

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

2

Small-scale

0.479

High

425794

RBX1
E3 ubiquitin-protein ligase RBX1

1

5

High-throughput

0.479

High

425800

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

2

High-throughput

0.479

High

425801

SQSTM
Sequestosome-1

1

3

High-throughput

0.479

High

425802

HDAC1
Histone deacetylase 1

1

10

High-throughput

0.479

High

425803

CUL3
Cullin-3

1

3

High-throughput

0.479

High

425811

DCA15
DDB1- and CUL4-associated factor 15

1

4

High-throughput

0.479

High

425813

ZN746
Zinc finger protein 746

1

4

High-throughput

0.479

High

425818

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

11

High-throughput

0.479

High

425820

NAA40
N-alpha-acetyltransferase 40

1

4

High-throughput

0.479

High

425822

SMC5
Structural maintenance of chromosomes protein 5

1

6

High-throughput

0.479

High

425824

WDTC1
WD and tetratricopeptide repeats protein 1

1

16

High-throughput

0.479

High

425827

ARL10
ADP-ribosylation factor-like protein 10

1

17

High-throughput

0.479

High

425831

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

2

High-throughput

0.479

High

425833

FBXW5
F-box/WD repeat-containing protein 5

1

2

High-throughput

0.479

High

425838

BICD1
Protein bicaudal D homolog 1

1

1

High-throughput

0.479

High

425844

RUFY1
RUN and FYVE domain-containing protein 1

1

4

High-throughput

0.479

High

425845

NECD
Necdin

1

3

High-throughput

0.479

High

425851

SAR1A
Small COPII coat GTPase SAR1A

1

20

High-throughput

0.479

High

425857

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

425862

DCTN4
Dynactin subunit 4

1

2

High-throughput

0.479

High

425863

RCOR1
REST corepressor 1

1

5

High-throughput

0.479

High

425864

ALK
ALK tyrosine kinase receptor

1

7

High-throughput

0.479

High

425869

SAR1B
Small COPII coat GTPase SAR1B

1

19

High-throughput

0.479

High

425861

ERRFI
ERBB receptor feedback inhibitor 1

1

0

Small-scale

0.460

High

365264

PGK1
Phosphoglycerate kinase 1

1

0

High-throughput

0.458

High

425783

GATA4
Transcription factor GATA-4

1

1

High-throughput

0.457

High

425768

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

8

High-throughput

0.445

High

425797

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

5

High-throughput

0.445

High

425809

KLH22
Kelch-like protein 22

1

1

High-throughput

0.445

High

425870

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

14

High-throughput

0.445

High

425798

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.438

High

105116

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

239661

PCDH7
Protocadherin-7

1

2

High-throughput

0.437

High

318571

RHBT1
Rho-related BTB domain-containing protein 1

1

8

High-throughput

0.437

High

352839

AGR2
Anterior gradient protein 2 homolog

1

4

High-throughput

0.437

High

370914

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.437

High

378939

PIGR
Polymeric immunoglobulin receptor

1

4

Small-scale

0.437

High

425770

SP100
Nuclear autoantigen Sp-100

1

2

High-throughput

0.437

High

425773

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

425776

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

425777

ARL3
ADP-ribosylation factor-like protein 3

1

13

High-throughput

0.437

High

425778

TRI23
E3 ubiquitin-protein ligase TRIM23

1

15

High-throughput

0.437

High

425779

CEAM6
Cell adhesion molecule CEACAM6

1

5

High-throughput

0.437

High

425786

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

5

High-throughput

0.437

High

425787

ARL4D
ADP-ribosylation factor-like protein 4D

1

17

High-throughput

0.437

High

425788

TSP3
Thrombospondin-3

1

1

High-throughput

0.437

High

425793

H4
Histone H4

1

4

High-throughput

0.437

High

425795

DYLT1
Dynein light chain Tctex-type 1

1

3

High-throughput

0.437

High

425796

ARF5
ADP-ribosylation factor 5

1

10

High-throughput

0.437

High

425804

TRI14
Tripartite motif-containing protein 14

1

1

High-throughput

0.437

High

425807

ISX
Intestine-specific homeobox

1

3

High-throughput

0.437

High

425815

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

425816

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

4

Small-scale

0.437

High

425817

DET1
DET1 homolog

1

4

High-throughput

0.437

High

425821

HOOK3
Protein Hook homolog 3

1

8

High-throughput

0.437

High

425823

SLX4
Structure-specific endonuclease subunit SLX4

1

6

High-throughput

0.437

High

425830

DCAF4
DDB1- and CUL4-associated factor 4

1

3

High-throughput

0.437

High

425832

TOPB1
DNA topoisomerase 2-binding protein 1

1

5

High-throughput

0.437

High

425834

PF21A
PHD finger protein 21A

1

5

High-throughput

0.437

High

425840

ARL5B
ADP-ribosylation factor-like protein 5B

1

18

High-throughput

0.437

High

425853

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

3

High-throughput

0.437

High

425854

VSX1
Visual system homeobox 1

1

3

High-throughput

0.437

High

425860

HOOK1
Protein Hook homolog 1

1

8

High-throughput

0.437

High

425868

ARL5A
ADP-ribosylation factor-like protein 5A

1

19

High-throughput

0.437

High

346804

BAG2
BAG family molecular chaperone regulator 2

1

0

Small-scale

0.426

High

425775

AL4A1
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

1

0

High-throughput

0.426

High

425789

SUOX
Sulfite oxidase, mitochondrial

1

0

High-throughput

0.426

High

425858

PARP2
Poly [ADP-ribose] polymerase 2

1

0

Small-scale

0.426

High

254263

ICMT
Protein-S-isoprenylcysteine O-methyltransferase

2

0

High-throughput

0.328

High

425865

LAMP3
Lysosome-associated membrane glycoprotein 3

2

0

High-throughput

0.328

High

425829

FA81A
Protein FAM81A

2

0

High-throughput

0.313

High

66919

AQ12B
Putative aquaporin-12B

1

0

High-throughput

0.279

Low

425808

TBC25
TBC1 domain family member 25

1

0

High-throughput

0.279

Low

425842

O52B2
Olfactory receptor 52B2

1

0

High-throughput

0.279

Low

425852

CT096
Uncharacterized protein C20orf96

1

0

High-throughput

0.279

Low

425828

PJA1
E3 ubiquitin-protein ligase Praja-1

1

0

Small-scale

0.261

Low

425805

T132D
Transmembrane protein 132D

1

0

Small-scale

0.251

Low

168803

PLD2
Phospholipase D2

1

0

High-throughput

0.249

Low

425826

PLD5
Inactive phospholipase D5

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025