Protein: MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (MCCase subunit alpha) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (3-methylcrotonyl-CoA carboxylase biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha)

Gene: MCCA, MCCC1
Organism: Homo sapiens
Interactions: 185
UniProt ID: Q96RQ3

Gene Ontology (top 5):
GO:0004075 - biotin carboxylase activity
GO:0004485 - methylcrotonoyl-CoA carboxylase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1401765

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

4

18

High-throughput

0.881

High

425950

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

2

19

High-throughput

0.789

High

425843

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

2

16

High-throughput

0.737

High

288251

KBL
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

3

2

High-throughput

0.667

High

1092630

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

3

2

High-throughput

0.667

High

1401756

SCOT2
Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial

3

0

High-throughput

0.638

High

275355

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

2

1

High-throughput

0.628

High

653517

HEMH
Ferrochelatase, mitochondrial

2

1

High-throughput

0.628

High

882831

EFTU
Elongation factor Tu, mitochondrial

2

5

High-throughput

0.628

High

1238409

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

2

2

High-throughput

0.628

High

1401774

SUCB1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

2

4

High-throughput

0.628

High

547193

PYC
Pyruvate carboxylase, mitochondrial

1

16

High-throughput

0.618

High

1094241

ACACA
Acetyl-CoA carboxylase 1

1

15

High-throughput

0.618

High

1386509

FXRD1
FAD-dependent oxidoreductase domain-containing protein 1

2

0

High-throughput

0.602

High

1401754

TMM70
Transmembrane protein 70, mitochondrial

2

0

High-throughput

0.602

High

869215

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

2

2

High-throughput

0.601

High

414451

P53
Cellular tumor antigen p53

2

5

Small-scale

0.584

High

831277

CCNF
Cyclin-F

2

5

High-throughput

0.584

High

1394547

MET2A
tRNA N(3)-cytidine methyltransferase METTL2A

2

1

High-throughput

0.574

High

1060719

SOS2
Son of sevenless homolog 2

2

1

High-throughput

0.571

High

289805

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

1

High-throughput

0.536

High

361655

OTC
Ornithine transcarbamylase, mitochondrial

1

4

High-throughput

0.536

High

488189

IFIT1
Antiviral innate immune response effector IFIT1

1

4

High-throughput

0.536

High

651858

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

3

High-throughput

0.536

High

834263

PLPL4
Patatin-like phospholipase domain-containing protein 4

1

1

High-throughput

0.536

High

842229

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

1

High-throughput

0.536

High

946521

YBEY
Endoribonuclease YbeY

1

2

High-throughput

0.536

High

1100637

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

1

High-throughput

0.536

High

1115371

CUL4B
Cullin-4B

1

3

High-throughput

0.536

High

1240320

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

1

High-throughput

0.536

High

1288369

TLK2
Serine/threonine-protein kinase tousled-like 2

1

8

High-throughput

0.536

High

1326815

CBR4
3-oxoacyl-[acyl-carrier-protein] reductase

1

2

High-throughput

0.536

High

1363502

DHB8
(3R)-3-hydroxyacyl-CoA dehydrogenase

1

2

High-throughput

0.536

High

1387787

ARHGQ
Rho guanine nucleotide exchange factor 26

1

1

High-throughput

0.536

High

1388988

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

2

High-throughput

0.536

High

1389177

RT24
Small ribosomal subunit protein uS3m

1

1

High-throughput

0.536

High

1401747

PFD5
Prefoldin subunit 5

1

1

High-throughput

0.536

High

1401751

NPS3B
Protein NipSnap homolog 3B

1

3

High-throughput

0.536

High

1401752

HDHD3
Haloacid dehalogenase-like hydrolase domain-containing protein 3

1

1

High-throughput

0.536

High

1401757

LDH6B
L-lactate dehydrogenase A-like 6B

1

2

High-throughput

0.536

High

1401762

MTG2
Mitochondrial ribosome-associated GTPase 2

1

5

High-throughput

0.536

High

1401776

DIC
Mitochondrial dicarboxylate carrier

1

2

High-throughput

0.536

High

1401777

NPS3A
Protein NipSnap homolog 3A

1

3

High-throughput

0.536

High

1401779

MRM2
rRNA methyltransferase 2, mitochondrial

1

1

High-throughput

0.536

High

1401783

AGO2
Protein argonaute-2

1

1

High-throughput

0.536

High

1401786

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

2

High-throughput

0.536

High

1401787

RT02
Small ribosomal subunit protein uS2m

1

3

High-throughput

0.536

High

372905

MYC
Myc proto-oncogene protein

2

6

High-throughput

0.533

High

870969

IREB2
Iron-responsive element-binding protein 2

1

1

High-throughput

0.515

High

977803

ACTA
Actin, aortic smooth muscle

1

0

High-throughput

0.513

High

1158270

RM23
Large ribosomal subunit protein uL23m

1

0

High-throughput

0.513

High

1243766

FXL19
F-box/LRR-repeat protein 19

1

0

High-throughput

0.513

High

1289422

FA83A
Protein FAM83A

1

0

High-throughput

0.513

High

1293454

NUD13
NAD(P)H pyrophosphatase NUDT13, mitochondrial

1

0

High-throughput

0.513

High

1328054

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

1

0

High-throughput

0.513

High

1401753

MYL10
Myosin regulatory light chain 10

1

0

High-throughput

0.513

High

1401759

COMD5
COMM domain-containing protein 5

1

0

High-throughput

0.513

High

1401768

ABHDA
Palmitoyl-protein thioesterase ABHD10, mitochondrial

1

0

High-throughput

0.513

High

326774

DUS14
Dual specificity protein phosphatase 14

1

3

High-throughput

0.489

High

1013373

HTRA3
Serine protease HTRA3

1

1

High-throughput

0.489

High

1330558

PAF1
RNA polymerase II-associated factor 1 homolog

1

4

High-throughput

0.489

High

1384940

TRI43
Tripartite motif-containing protein 43

1

2

High-throughput

0.489

High

1401750

NAA38
N-alpha-acetyltransferase 38, NatC auxiliary subunit

1

1

High-throughput

0.489

High

125576

LEG9
Galectin-9

1

6

High-throughput

0.479

High

159811

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

2

High-throughput

0.479

High

176222

PER2
Period circadian protein homolog 2

1

4

Small-scale

0.479

High

242660

PRKN
E3 ubiquitin-protein ligase parkin

1

10

High-throughput

0.479

High

284606

ECI2
Enoyl-CoA delta isomerase 2

1

2

High-throughput

0.479

High

346216

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

412467

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.479

High

415803

HSPB1
Heat shock protein beta-1

1

2

Small-scale

0.479

High

508476

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

Small-scale

0.479

High

537750

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

564249

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.479

High

609781

LEG3
Galectin-3

1

6

Small-scale

0.479

High

612287

ARF4
ADP-ribosylation factor 4

1

11

High-throughput

0.479

High

633388

MX1
Interferon-induced GTP-binding protein Mx1

1

1

High-throughput

0.479

High

691356

1433T
14-3-3 protein theta

1

6

High-throughput

0.479

High

861736

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

12

Small-scale

0.479

High

951819

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

7

Small-scale

0.479

High

979158

RS6
Small ribosomal subunit protein eS6

1

3

High-throughput

0.479

High

983946

RBX1
E3 ubiquitin-protein ligase RBX1

1

6

High-throughput

0.479

High

1014946

ARF1
ADP-ribosylation factor 1

1

11

High-throughput

0.479

High

1110009

HDAC1
Histone deacetylase 1

1

12

High-throughput

0.479

High

1115937

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

3

High-throughput

0.479

High

1150562

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

1

Small-scale

0.479

High

1194303

LARP7
La-related protein 7

1

3

High-throughput

0.479

High

1211791

SYRM
Probable arginine--tRNA ligase, mitochondrial

1

1

High-throughput

0.479

High

1226502

DCA15
DDB1- and CUL4-associated factor 15

1

4

High-throughput

0.479

High

1238463

ZN746
Zinc finger protein 746

1

4

High-throughput

0.479

High

1278080

MAVS
Mitochondrial antiviral-signaling protein

1

6

Small-scale

0.479

High

1280420

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

12

High-throughput

0.479

High

1289557

NAA40
N-alpha-acetyltransferase 40

1

4

High-throughput

0.479

High

1313359

SMC5
Structural maintenance of chromosomes protein 5

1

8

High-throughput

0.479

High

1331239

ARL10
ADP-ribosylation factor-like protein 10

1

18

High-throughput

0.479

High

1333317

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.479

High

1401746

RUFY1
RUN and FYVE domain-containing protein 1

1

4

High-throughput

0.479

High

1401749

NECD
Necdin

1

3

High-throughput

0.479

High

1401758

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

1

High-throughput

0.479

High

1401760

RN208
RING finger protein 208

1

5

Small-scale

0.479

High

1401766

SAR1A
Small COPII coat GTPase SAR1A

1

20

High-throughput

0.479

High

1401769

ARL8B
ADP-ribosylation factor-like protein 8B

1

8

High-throughput

0.479

High

1401778

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1401781

DCTN4
Dynactin subunit 4

1

2

High-throughput

0.479

High

1401784

ALK
ALK tyrosine kinase receptor

1

7

High-throughput

0.479

High

1401788

TRAF6
TNF receptor-associated factor 6

1

3

Small-scale

0.479

High

1401790

SAR1B
Small COPII coat GTPase SAR1B

1

20

High-throughput

0.479

High

898521

PPT1
Palmitoyl-protein thioesterase 1

1

0

High-throughput

0.458

High

903631

GALK1
Galactokinase

1

0

Small-scale

0.458

High

939644

BID
BH3-interacting domain death agonist

1

0

Small-scale

0.458

High

975882

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.458

High

1359179

MAIP1
m-AAA protease-interacting protein 1, mitochondrial

1

0

High-throughput

0.458

High

1361694

CHC10
Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial

1

0

High-throughput

0.458

High

1401772

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1401785

LHX6
LIM/homeobox protein Lhx6

1

0

High-throughput

0.458

High

851644

GATA4
Transcription factor GATA-4

1

1

High-throughput

0.457

High

457628

TBB5
Tubulin beta chain

1

3

High-throughput

0.445

High

626338

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

8

High-throughput

0.445

High

848061

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

2

High-throughput

0.445

High

935029

TERA
Transitional endoplasmic reticulum ATPase

1

7

High-throughput

0.445

High

1023863

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

5

High-throughput

0.445

High

1093163

STK4
Serine/threonine-protein kinase 4

1

10

High-throughput

0.445

High

1340503

DNJB8
DnaJ homolog subfamily B member 8

1

6

High-throughput

0.445

High

1401764

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

1

High-throughput

0.445

High

1401791

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

15

High-throughput

0.445

High

106512

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

239875

PCDH7
Protocadherin-7

1

2

High-throughput

0.437

High

246883

KDM1A
Lysine-specific histone demethylase 1A

1

4

High-throughput

0.437

High

318859

RHBT1
Rho-related BTB domain-containing protein 1

1

9

High-throughput

0.437

High

353514

AGR2
Anterior gradient protein 2 homolog

1

4

High-throughput

0.437

High

379036

PIGR
Polymeric immunoglobulin receptor

1

4

Small-scale

0.437

High

589467

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

696275

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.437

High

768951

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

783379

TRI23
E3 ubiquitin-protein ligase TRIM23

1

16

High-throughput

0.437

High

820725

CEAM6
Cell adhesion molecule CEACAM6

1

5

High-throughput

0.437

High

879380

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

5

High-throughput

0.437

High

886306

ARL4D
ADP-ribosylation factor-like protein 4D

1

18

High-throughput

0.437

High

980179

H4
Histone H4

1

5

High-throughput

0.437

High

991914

DYLT1
Dynein light chain Tctex-type 1

1

3

High-throughput

0.437

High

1010773

SSBP2
Single-stranded DNA-binding protein 2

1

2

Small-scale

0.437

High

1015095

ARF5
ADP-ribosylation factor 5

1

11

High-throughput

0.437

High

1071183

ARL16
ADP-ribosylation factor-like protein 16

1

20

High-throughput

0.437

High

1178671

ISX
Intestine-specific homeobox

1

3

High-throughput

0.437

High

1241935

FBX42
F-box only protein 42

1

3

High-throughput

0.437

High

1255160

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

1258072

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

4

Small-scale

0.437

High

1272663

DET1
DET1 homolog

1

4

High-throughput

0.437

High

1289279

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

3

High-throughput

0.437

High

1291565

HOOK3
Protein Hook homolog 3

1

8

High-throughput

0.437

High

1314374

SLX4
Structure-specific endonuclease subunit SLX4

1

6

High-throughput

0.437

High

1364215

TOPB1
DNA topoisomerase 2-binding protein 1

1

5

High-throughput

0.437

High

1368069

HDAC2
Histone deacetylase 2

1

12

High-throughput

0.437

High

1384420

PF21A
PHD finger protein 21A

1

6

High-throughput

0.437

High

1395904

ARL5B
ADP-ribosylation factor-like protein 5B

1

19

High-throughput

0.437

High

1399191

NP1L5
Nucleosome assembly protein 1-like 5

1

1

High-throughput

0.437

High

1401748

RING2
E3 ubiquitin-protein ligase RING2

1

13

High-throughput

0.437

High

1401761

UN93B
Protein unc-93 homolog B1

1

1

High-throughput

0.437

High

1401763

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.437

High

1401770

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

3

High-throughput

0.437

High

1401773

VSX1
Visual system homeobox 1

1

3

High-throughput

0.437

High

1401780

HOOK1
Protein Hook homolog 1

1

8

High-throughput

0.437

High

1401782

RCOR1
REST corepressor 1

1

5

High-throughput

0.437

High

1401789

ARL5A
ADP-ribosylation factor-like protein 5A

1

20

High-throughput

0.437

High

169313

LECT2
Leukocyte cell-derived chemotaxin-2

1

0

High-throughput

0.426

High

192741

ARPC5
Actin-related protein 2/3 complex subunit 5

1

0

High-throughput

0.426

High

1135920

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

0

Small-scale

0.426

High

1387437

CMBL
Carboxymethylenebutenolidase homolog

1

0

High-throughput

0.426

High

1401755

TR61B
tRNA

1

0

High-throughput

0.426

High

1401771

TRM1
tRNA

1

0

High-throughput

0.426

High

295622

CIB2
Calcium and integrin-binding family member 2

1

2

High-throughput

0.407

High

346775

CER1
Cerberus

1

1

High-throughput

0.407

High

628449

KLK2
Kallikrein-2

1

5

High-throughput

0.407

High

955893

GMFB
Glia maturation factor beta

1

1

High-throughput

0.407

High

1247283

WDR74
WD repeat-containing protein 74

1

18

High-throughput

0.407

High

1384586

ESPB1
Epididymal sperm-binding protein 1

1

2

High-throughput

0.407

High

1401775

DNJB9
DnaJ homolog subfamily B member 9

1

4

High-throughput

0.407

High

1339901

NPB
Neuropeptide B

2

0

High-throughput

0.328

High

1286461

DSG4
Desmoglein-4

1

0

High-throughput

0.279

Low

1330705

STPG3
Protein STPG3

1

0

High-throughput

0.279

Low

1103330

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.249

Low

1401767

SALL1
Sal-like protein 1

1

0

High-throughput

0.249

Low

255178

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low

690050

CRBB3
Beta-crystallin B3

1

0

High-throughput

0.232

Low

1308288

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025