HitPredict

Interactor 1: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Interactor 2: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	27684187, 30472188
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0003713 - transcription coactivator activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 526 Hs			1 504
+	Hs
		125616 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54
+	Hs
		125387 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54
+	Hs
		967360 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17
+	Hs
		967423 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42
+	Hs
		125430 PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00		WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54
+	Hs
		125122 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54
+	Hs
		125274 SC24C_HUMAN (1-262): 5.36e-11: 67.4: 14.34		WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54
+	Hs
		516643 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17
+	Hs
		808338 RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35		NEDD4_HUMAN (40-504): 2.15e-103: 338: 19.26
+	Hs
		516402 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Hs
		808925 PABP3_HUMAN (275-379): 5.23e-10: 63.9: 19.05		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Dm
		1374363 Q9VUH6_DROME (28-222): 2.25e-09: 62.6: 22.27		SUDX_DROME (16-504): 4.46e-109: 347: 15.74
+	Dm
		1099578 CAZ_DROME (175-481): 5.46e-34: 134: 38.91		YAP1_DROME (52-268): 1.16e-44: 163: 29.25
+	Hs
		727067 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		WWOX_HUMAN (166-263): 7.4e-29: 120: 30.61
+	Sc
		376913 PABP_YEAST (263-381): 1.57e-10: 65.5: 18.49		TOM1_YEAST (261-504): 2.18e-46: 176: 11.34
+	Dm
		1115153 Q9VUH6_DROME (28-222): 2.25e-09: 62.6: 22.27		YAP1_DROME (52-268): 1.16e-44: 163: 29.25
+	Hs
		1031480 PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00		WWOX_HUMAN (166-263): 7.4e-29: 120: 30.61
+	Hs
		516721 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		WWOX_HUMAN (166-263): 7.4e-29: 120: 30.61
+	Hs
		867138 SC24C_HUMAN (1-262): 5.36e-11: 67.4: 14.34		WWOX_HUMAN (166-263): 7.4e-29: 120: 30.61
+	Hs
		1329986 PABP3_HUMAN (275-379): 5.23e-10: 63.9: 19.05		WWOX_HUMAN (166-263): 7.4e-29: 120: 30.61