Protein: SDC2
Syndecan-2 (SYND2) (Fibroglycan) (Heparan sulfate proteoglycan core protein) (HSPG) (CD antigen CD362)

Gene: SDC2
Organism: Homo sapiens
Interactions: 176
UniProt ID: P34741

Gene Ontology (top 5):
GO:0005788 - endoplasmic reticulum lumen
GO:0005796 - Golgi lumen
GO:0005886 - plasma membrane
GO:0009986 - cell surface
GO:0016477 - cell migration

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

760404

SDC2
Syndecan-2

3

14

Small-scale

0.850

High

726640

SDC4
Syndecan-4

3

15

Small-scale

0.847

High

616724

SDC1
Syndecan-1

2

15

Small-scale

0.799

High

193515

PDPK1
3-phosphoinositide-dependent protein kinase 1

5

2

Small-scale

0.716

High

760477

CAMKV
CaM kinase-like vesicle-associated protein

4

2

High-throughput

0.697

High

140155

SDCB1
Syntenin-1

4

4

Small-scale

0.686

High

733485

GP183
G-protein coupled receptor 183

3

4

High-throughput

0.667

High

478454

FGF2
Fibroblast growth factor 2

6

9

Small-scale

0.665

High

760469

KLHL7
Kelch-like protein 7

3

2

High-throughput

0.662

High

760478

VANG1
Vang-like protein 1

3

5

High-throughput

0.662

High

760492

SNX18
Sorting nexin-18

3

3

High-throughput

0.662

High

760494

SEM3C
Semaphorin-3C

3

1

High-throughput

0.662

High

269908

SDC3
Syndecan-3

1

15

Small-scale

0.647

High

760493

S10AD
Protein S100-A13

3

0

High-throughput

0.634

High

641130

FGFR2
Fibroblast growth factor receptor 2

2

4

High-throughput

0.628

High

650066

FGFR3
Fibroblast growth factor receptor 3

2

5

High-throughput

0.628

High

760467

SULF2
Extracellular sulfatase Sulf-2

2

2

High-throughput

0.628

High

760468

SULF1
Extracellular sulfatase Sulf-1

2

2

High-throughput

0.628

High

760475

FGRL1
Fibroblast growth factor receptor-like 1

2

6

High-throughput

0.628

High

760481

SNX33
Sorting nexin-33

2

3

High-throughput

0.628

High

760512

VANG2
Vang-like protein 2

2

5

High-throughput

0.628

High

760517

FARP1
FERM, ARHGEF and pleckstrin domain-containing protein 1

2

4

High-throughput

0.628

High

760427

AMPD2
AMP deaminase 2

4

2

High-throughput

0.627

High

168641

CSKP
Peripheral plasma membrane protein CASK

2

1

Small-scale

0.620

High

760416

EFNB2
Ephrin-B2

2

3

High-throughput

0.611

High

252836

EXOC3
Exocyst complex component 3

3

1

High-throughput

0.604

High

760407

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

3

6

High-throughput

0.604

High

760420

ECHB
Trifunctional enzyme subunit beta, mitochondrial

3

3

High-throughput

0.604

High

760442

ZN460
Zinc finger protein 460

3

2

High-throughput

0.604

High

760472

TM192
Transmembrane protein 192

3

1

High-throughput

0.604

High

760485

TM186
Transmembrane protein 186

3

1

High-throughput

0.604

High

760496

OSBL8
Oxysterol-binding protein-related protein 8

3

3

High-throughput

0.604

High

760511

GMEB2
Glucocorticoid modulatory element-binding protein 2

3

5

High-throughput

0.604

High

760520

GMEB1
Glucocorticoid modulatory element-binding protein 1

3

5

High-throughput

0.604

High

602199

TMM11
Transmembrane protein 11, mitochondrial

2

0

High-throughput

0.602

High

760428

XPC
DNA repair protein complementing XP-C cells

2

0

High-throughput

0.602

High

760440

CKAP5
Cytoskeleton-associated protein 5

2

0

High-throughput

0.602

High

760482

CTR3
Cationic amino acid transporter 3

2

0

High-throughput

0.602

High

760425

RHOB
Rho-related GTP-binding protein RhoB

2

4

High-throughput

0.584

High

760433

ASPH
Aspartyl/asparaginyl beta-hydroxylase

2

0

High-throughput

0.580

High

760445

LAMA3
Laminin subunit alpha-3

1

1

Small-scale

0.578

High

502254

H2A1
Histone H2A type 1

2

1

High-throughput

0.574

High

760429

ZNF92
Zinc finger protein 92

2

1

High-throughput

0.574

High

760432

TF3C1
General transcription factor 3C polypeptide 1

2

2

High-throughput

0.574

High

760436

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

2

4

High-throughput

0.574

High

760480

TF3C2
General transcription factor 3C polypeptide 2

2

1

High-throughput

0.574

High

760491

TEFM
Transcription elongation factor, mitochondrial

2

1

High-throughput

0.574

High

760505

PRD10
PR domain zinc finger protein 10

2

4

High-throughput

0.574

High

760509

PARP2
Poly [ADP-ribose] polymerase 2

2

2

High-throughput

0.574

High

582685

EZRI
Ezrin

1

6

Small-scale

0.561

High

75757

B3KW44
tRNA N(3)-cytidine methyltransferase

2

3

High-throughput

0.558

High

426942

FGF1
Fibroblast growth factor 1

2

9

High-throughput

0.558

High

760454

IFIX
Pyrin and HIN domain-containing protein 1

2

3

High-throughput

0.558

High

760506

EVA1B
Protein eva-1 homolog B

2

1

High-throughput

0.549

High

250478

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

2

1

High-throughput

0.549

High

557135

SRC
Proto-oncogene tyrosine-protein kinase Src

1

2

High-throughput

0.536

High

639107

SYT1
Synaptotagmin-1

1

3

High-throughput

0.536

High

760439

MTR1L
Melatonin-related receptor

1

1

High-throughput

0.536

High

760441

DOCK1
Dedicator of cytokinesis protein 1

1

2

High-throughput

0.536

High

760474

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

1

High-throughput

0.536

High

760489

EXOC2
Exocyst complex component 2

1

1

High-throughput

0.536

High

760503

DOCK5
Dedicator of cytokinesis protein 5

1

1

High-throughput

0.536

High

760444

TNIP1
TNFAIP3-interacting protein 1

2

1

High-throughput

0.533

High

186889

GPR37
Prosaposin receptor GPR37

1

2

High-throughput

0.515

High

71637

ELAP2
Endosome/lysosome-associated apoptosis and autophagy regulator family member 2

1

0

High-throughput

0.513

High

194808

KCNN4
Intermediate conductance calcium-activated potassium channel protein 4

1

0

High-throughput

0.513

High

271673

HIP1R
Huntingtin-interacting protein 1-related protein

1

0

High-throughput

0.513

High

760519

LIPG
Endothelial lipase

1

0

High-throughput

0.513

High

637855

NF1
Neurofibromin

1

3

Small-scale

0.508

High

389088

FINC
Fibronectin

1

2

Small-scale

0.501

High

424637

KPCG
Protein kinase C gamma type

1

4

Small-scale

0.501

High

436620

KPCB
Protein kinase C beta type

1

4

Small-scale

0.501

High

507593

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

High-throughput

0.501

High

603183

KPCA
Protein kinase C alpha type

1

4

Small-scale

0.501

High

760434

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

3

Small-scale

0.501

High

256447

TOM1
Target of Myb1 membrane trafficking protein

1

0

High-throughput

0.493

High

301357

WFS1
Wolframin

1

0

High-throughput

0.493

High

699612

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

0

High-throughput

0.493

High

705252

GRN
Progranulin

1

0

High-throughput

0.493

High

760437

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

1

0

High-throughput

0.493

High

760459

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

0

High-throughput

0.493

High

277574

H2AY
Core histone macro-H2A.1

1

2

High-throughput

0.489

High

472388

FGF4
Fibroblast growth factor 4

1

9

High-throughput

0.489

High

517618

ZBT48
Zinc finger and BTB domain-containing protein 48

1

1

High-throughput

0.489

High

625218

CSK22
Casein kinase II subunit alpha'

1

2

High-throughput

0.489

High

760465

H2A2B
Histone H2A type 2-B

1

1

High-throughput

0.489

High

760507

LYAR
Cell growth-regulating nucleolar protein

1

1

High-throughput

0.489

High

760510

GT2D1
General transcription factor II-I repeat domain-containing protein 1

1

1

High-throughput

0.489

High

592625

ITB4
Integrin beta-4

1

6

Small-scale

0.481

High

403272

CSF2
Granulocyte-macrophage colony-stimulating factor

1

0

Small-scale

0.480

High

362858

EGFR
Epidermal growth factor receptor

1

6

High-throughput

0.479

High

410660

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

6

High-throughput

0.479

High

580893

RAC2
Ras-related C3 botulinum toxin substrate 2

1

3

High-throughput

0.479

High

584631

CSF2R
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

1

1

Small-scale

0.479

High

635680

RASA1
Ras GTPase-activating protein 1

1

3

Small-scale

0.479

High

657211

KALM
Anosmin-1

1

3

Small-scale

0.479

High

760405

BASI
Basigin

1

2

High-throughput

0.479

High

760418

ATX3
Ataxin-3

1

1

High-throughput

0.479

High

760422

RAC3
Ras-related C3 botulinum toxin substrate 3

1

3

High-throughput

0.479

High

760424

RHOA
Transforming protein RhoA

1

4

High-throughput

0.479

High

760426

RAC1
Ras-related C3 botulinum toxin substrate 1

1

3

High-throughput

0.479

High

760502

E41L1
Band 4.1-like protein 1

1

6

Small-scale

0.479

High

369320

A1AT
Alpha-1-antitrypsin

1

0

High-throughput

0.460

High

750557

CP2CI
Cytochrome P450 2C18

1

0

High-throughput

0.460

High

760406

BMR1A
Bone morphogenetic protein receptor type-1A

1

0

High-throughput

0.458

High

760419

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

Small-scale

0.458

High

760443

ITPR1
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1

1

0

Small-scale

0.458

High

760500

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

571181

HGF
Hepatocyte growth factor

1

1

Small-scale

0.457

High

760411

PI4KA
Phosphatidylinositol 4-kinase alpha

1

1

High-throughput

0.445

High

760421

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.445

High

760464

C2CD5
C2 domain-containing protein 5

1

5

High-throughput

0.445

High

760476

SYT2
Synaptotagmin-2

1

3

High-throughput

0.445

High

760483

GSLG1
Golgi apparatus protein 1

1

1

High-throughput

0.445

High

760486

S67A1
Solute carrier family 67 member A1

1

2

High-throughput

0.445

High

129670

CBX4
E3 SUMO-protein ligase CBX4

1

1

High-throughput

0.437

High

760410

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.437

High

760417

VMAT1
Chromaffin granule amine transporter

1

1

High-throughput

0.437

High

760423

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

1

High-throughput

0.437

High

760435

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

4

High-throughput

0.437

High

760438

SQSTM
Sequestosome-1

1

2

High-throughput

0.437

High

760447

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

1

High-throughput

0.437

High

760462

TAXB1
Tax1-binding protein 1

1

4

High-throughput

0.437

High

760488

OPTN
Optineurin

1

2

High-throughput

0.437

High

760501

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.437

High

760521

ZNT1
Proton-coupled zinc antiporter SLC30A1

1

0

High-throughput

0.426

High

215982

FIBP
Acidic fibroblast growth factor intracellular-binding protein

1

2

High-throughput

0.407

High

337692

SGPL1
Sphingosine-1-phosphate lyase 1

1

2

High-throughput

0.407

High

760431

ECHP
Peroxisomal bifunctional enzyme

1

6

High-throughput

0.407

High

760448

NCBP3
Nuclear cap-binding protein subunit 3

1

1

High-throughput

0.407

High

760461

LRRT1
Leucine-rich repeat transmembrane neuronal protein 1

1

6

High-throughput

0.407

High

760471

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.407

High

760473

SLN12
Ribonuclease SLFN12

1

1

High-throughput

0.407

High

760479

EOLA1
Protein EOLA1

1

2

High-throughput

0.407

High

760495

DHRS4
Dehydrogenase/reductase SDR family member 4

1

4

High-throughput

0.407

High

760499

OSBL5
Oxysterol-binding protein-related protein 5

1

3

High-throughput

0.407

High

760504

METL8
tRNA N(3)-cytidine methyltransferase METTL8, mitochondrial

1

3

High-throughput

0.407

High

760513

ZBTB1
Zinc finger and BTB domain-containing protein 1

1

4

High-throughput

0.407

High

273166

CAND2
Cullin-associated NEDD8-dissociated protein 2

2

0

High-throughput

0.328

High

760450

RN213
E3 ubiquitin-protein ligase RNF213

2

0

High-throughput

0.328

High

760452

HEAT6
HEAT repeat-containing protein 6

2

0

High-throughput

0.328

High

760453

CNDH2
Condensin-2 complex subunit H2

2

0

High-throughput

0.328

High

760456

NBEL1
Neurobeachin-like protein 1

2

0

High-throughput

0.328

High

760516

DOP1B
Protein DOP1B

2

0

High-throughput

0.328

High

760518

TF3C3
General transcription factor 3C polypeptide 3

2

0

High-throughput

0.328

High

231453

ORC4
Origin recognition complex subunit 4

1

0

High-throughput

0.279

Low

333949

SMC2
Structural maintenance of chromosomes protein 2

1

0

High-throughput

0.279

Low

760446

HKDC1
Hexokinase HKDC1

1

0

High-throughput

0.279

Low

760457

MON2
Protein MON2 homolog

1

0

High-throughput

0.279

Low

760458

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

760460

LYRIC
Protein LYRIC

1

0

High-throughput

0.279

Low

760463

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

1

0

High-throughput

0.279

Low

760466

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.279

Low

760470

PLPL6
Patatin-like phospholipase domain-containing protein 6

1

0

High-throughput

0.279

Low

760484

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

0

High-throughput

0.279

Low

760487

ELMO3
Engulfment and cell motility protein 3

1

0

High-throughput

0.279

Low

760490

TSNA1
t-SNARE domain-containing protein 1

1

0

High-throughput

0.279

Low

760497

DDX24
ATP-dependent RNA helicase DDX24

1

0

High-throughput

0.279

Low

760498

TSYL1
Testis-specific Y-encoded-like protein 1

1

0

High-throughput

0.279

Low

760514

MAN1
Inner nuclear membrane protein Man1

1

0

High-throughput

0.279

Low

109371

G5E9A7
DM1 locus, WD repeat containing

1

0

High-throughput

0.268

Low

245878

KIF1B
Kinesin-like protein KIF1B

1

0

High-throughput

0.268

Low

760409

NBL1
Neuroblastoma suppressor of tumorigenicity 1

1

0

High-throughput

0.268

Low

760455

ESRP1
Epithelial splicing regulatory protein 1

1

0

High-throughput

0.268

Low

760515

RNF11
RING finger protein 11

1

0

High-throughput

0.268

Low

760430

REG3A
Regenerating islet-derived protein 3-alpha

1

0

Small-scale

0.261

Low

760412

BAG6
Large proline-rich protein BAG6

1

0

High-throughput

0.251

Low

760414

PP2BC
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

1

0

High-throughput

0.251

Low

519340

MYB
Transcriptional activator Myb

1

0

High-throughput

0.249

Low

760408

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

760413

BRCC3
Lys-63-specific deubiquitinase BRCC36

1

0

Small-scale

0.249

Low

760508

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.249

Low

760415

EI2BB
Translation initiation factor eIF2B subunit beta

1

0

High-throughput

0.232

Low

760449

H37
Histone H3-7

1

0

High-throughput

0.232

Low

760451

USF3
Basic helix-loop-helix domain-containing protein USF3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025