HitPredict

Interactor 1: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Interactor 2: ROA3 (P51991)
Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3)
Gene: HNRNPA3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.839

Property	Details
Experiments	29884807, 35271311, 27460707
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0003730 - mRNA 3'-UTR binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 526 Hs			1 378
+	Hs
		161976 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		HNRDL_HUMAN (20-303): 9.32e-70: 226: 32.30
+	Hs
		852117 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		ROA3_HUMAN (1-209): 2.02e-60: 201: 100.00
+	Hs
		162015 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		HNRDL_HUMAN (20-303): 9.32e-70: 226: 32.30
+	Hs
		726810 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		HNRPD_HUMAN (8-299): 1.73e-54: 184: 34.59
+	Hs
		852019 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		ROA3_HUMAN (1-209): 2.02e-60: 201: 100.00
+	Hs
		967165 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		HNRPD_HUMAN (8-299): 1.73e-54: 184: 34.59
+	Hs
		1271174 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		ROAA_HUMAN (12-208): 7.23e-36: 135: 38.38
+	Hs
		727006 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		ROAA_HUMAN (12-208): 7.23e-36: 135: 38.38
+	Hs
		609978 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		ROA2_HUMAN (8-126): 3.48e-26: 109: 29.27
+	Hs
		967387 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		ROAA_HUMAN (12-208): 7.23e-36: 135: 38.38
+	Hs
		609735 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		ROA2_HUMAN (8-126): 3.48e-26: 109: 29.27
+	Hs
		453508 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		ROA1_HUMAN (8-116): 5.62e-19: 89.4: 29.20
+	Hs
		1031411 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		PABP4_HUMAN (6-339): 1.18e-16: 83.6: 13.82
+	Hs
		453189 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		ROA1_HUMAN (8-116): 5.62e-19: 89.4: 29.20
+	Hs
		516620 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		PABP1_HUMAN (6-328): 5.14e-15: 78.6: 12.84
+	Hs
		609816 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		ROA2_HUMAN (8-126): 3.48e-26: 109: 29.27
+	Hs
		726795 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		PABP4_HUMAN (6-339): 1.18e-16: 83.6: 13.82
+	Hs
		516383 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		PABP1_HUMAN (6-328): 5.14e-15: 78.6: 12.84
+	Hs
		453296 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		ROA1_HUMAN (8-116): 5.62e-19: 89.4: 29.20
+	Hs
		726789 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		ROA0_HUMAN (17-115): 5.36e-10: 62: 34.34