Protein: SULF1
Extracellular sulfatase Sulf-1 (hSulf-1) (Arylsulfatase) (EC 3.1.6.1) (N-acetylglucosamine-6-sulfatase) (EC 3.1.6.14) [Cleaved into: Extracellular sulfatase Sulf-2 secreted form]

Gene: SULF1
Organism: Homo sapiens
Interactions: 33
UniProt ID: Q8IWU6

Gene Ontology (top 5):
GO:0001822 - kidney development
GO:0001937 - negative regulation of endothelial cell proliferation
GO:0002063 - chondrocyte development
GO:0003094 - glomerular filtration
GO:0004065 - arylsulfatase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1310993

SULF2
Extracellular sulfatase Sulf-2

1

7

High-throughput

0.691

High

422524

A4
Amyloid-beta precursor protein

3

3

High-throughput

0.670

High

760468

SDC2
Syndecan-2

2

2

High-throughput

0.628

High

1311065

LRC4C
Leucine-rich repeat-containing protein 4C

2

1

High-throughput

0.628

High

1278863

LYZL2
Lysozyme-like protein 2

2

5

High-throughput

0.574

High

1311067

INSL5
Insulin-like peptide INSL5

2

4

High-throughput

0.574

High

316675

LY6H
Lymphocyte antigen 6H

1

1

High-throughput

0.536

High

377642

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.536

High

437729

HEPS
Serine protease hepsin

1

5

High-throughput

0.536

High

518871

CCL3
C-C motif chemokine 3

1

5

High-throughput

0.536

High

593432

PGFRA
Platelet-derived growth factor receptor alpha

1

6

High-throughput

0.536

High

1047623

NOTC2
Neurogenic locus notch homolog protein 2

1

2

High-throughput

0.536

High

1101379

SG2A2
Mammaglobin-A

1

6

High-throughput

0.536

High

1105507

OS9
Protein OS-9

1

2

High-throughput

0.536

High

1308259

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

3

High-throughput

0.536

High

1311066

FBX2
F-box only protein 2

1

10

High-throughput

0.536

High

1311068

ST14
Suppressor of tumorigenicity 14 protein

1

7

High-throughput

0.536

High

1099629

NOGG
Noggin

1

0

High-throughput

0.513

High

1311064

RETNB
Resistin-like beta

1

0

High-throughput

0.513

High

861675

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

1

High-throughput

0.501

High

1311061

ZCH10
Zinc finger CCHC domain-containing protein 10

1

1

High-throughput

0.489

High

1311062

CA054
Uncharacterized protein C1orf54

1

6

High-throughput

0.489

High

1311063

LCFC1
Sperm-egg fusion protein LLCFC1

1

4

High-throughput

0.489

High

1132291

GOGB1
Golgin subfamily B member 1

1

2

High-throughput

0.479

High

1311060

CGAS
Cyclic GMP-AMP synthase

1

0

High-throughput

0.458

High

384476

CRYAA
Alpha-crystallin A chain

1

1

High-throughput

0.457

High

222299

PSCA
Prostate stem cell antigen

1

3

High-throughput

0.445

High

1141763

EEA1
Early endosome antigen 1

1

2

High-throughput

0.437

High

1115794

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.282

High

631813

MCH
Pro-MCH [Cleaved into: Neuropeptide-glycine-glutamic acid

1

0

High-throughput

0.279

Low

1081288

SYCN
Syncollin

1

0

High-throughput

0.279

Low

1103098

MFAP5
Microfibrillar-associated protein 5

1

0

High-throughput

0.279

Low

947016

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025