HitPredict

Interactor 1: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Interactor 2: CPSF1 (Q10570)
Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit)
Gene: CPSF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	33469008, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CPSF_A~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 526 Hs			1 1443
+	Hs
		1014178 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		CPSF1_HUMAN (1-1443): 0: 1602: 100.00
+	Hs
		1073089 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		SF3B3_HUMAN (890-1442): 5.69e-137: 454: 15.50
+	Hs
		967208 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		DDB1_HUMAN (738-1438): 2.28e-146: 478: 16.85
+	Hs
		726838 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		SF3B3_HUMAN (890-1442): 5.69e-137: 454: 15.50
+	Hs
		967195 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		SF3B3_HUMAN (890-1442): 5.69e-137: 454: 15.50
+	Sc
		865189 CUS2_YEAST (270-404): 1.07e-33: 131: 23.57		RSE1_YEAST (1-726): 3.88e-97: 344: 14.10
+	Sc
		376929 PABP_YEAST (263-381): 1.57e-10: 65.5: 18.49		RSE1_YEAST (1-726): 3.88e-97: 344: 14.10