HitPredict

Interactor 1: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Interactor 2: PSPC1 (Q8WXF1)
Paraspeckle component 1 (Paraspeckle protein 1)
Gene: PSPC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25192599
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	NOPS~RRM_1, RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0006355 - regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 526 Hs			1 523
+	Mm
		1207136 Q8BQ46_MOUSE (42-460): 2.55e-40: 155: 48.34		PSPC1_MOUSE (1-523): 9.43e-82: 265: 97.33
+	Hs
		516620 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		PABP1_HUMAN (4-522): 4.65e-70: 237: 14.16
+	Mm
		1142777 EWS_MOUSE (3-451): 2.8e-30: 127: 35.56		PSPC1_MOUSE (1-523): 9.43e-82: 265: 97.33
+	Hs
		1069757 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		NONO_HUMAN (50-523): 4.22e-68: 228: 57.60
+	Hs
		516383 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		PABP1_HUMAN (4-522): 4.65e-70: 237: 14.16
+	Hs
		726834 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		NONO_HUMAN (50-523): 4.22e-68: 228: 57.60
+	Hs
		613537 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		SFPQ_HUMAN (53-523): 3.05e-59: 210: 54.14
+	Hs
		613355 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		SFPQ_HUMAN (53-523): 3.05e-59: 210: 54.14
+	Hs
		967193 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		NONO_HUMAN (50-523): 4.22e-68: 228: 57.60
+	Mm
		1142788 EWS_MOUSE (3-451): 2.8e-30: 127: 35.56		NONO_MOUSE (45-523): 1.13e-66: 224: 57.83
+	Hs
		613422 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		SFPQ_HUMAN (53-523): 3.05e-59: 210: 54.14
+	Hs
		1031411 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		PABP4_HUMAN (3-149): 2.52e-27: 118: 18.83
+	Hs
		726795 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		PABP4_HUMAN (3-149): 2.52e-27: 118: 18.83
+	Hs
		1077435 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		ELAV1_HUMAN (84-156): 3.1e-13: 72.6: 29.11
+	Hs
		726921 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		RAVR1_HUMAN (84-234): 5.69e-14: 76.4: 23.35
+	Hs
		726846 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		ELAV1_HUMAN (84-156): 3.1e-13: 72.6: 29.11
+	Mm
		1207135 Q8BQ46_MOUSE (42-460): 2.55e-40: 155: 48.34		RBM4_MOUSE (83-190): 3.35e-09: 60.5: 33.04
+	Hs
		642763 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		ELAV4_HUMAN (41-156): 2.45e-16: 82.6: 32.79
+	Hs
		967202 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		ELAV1_HUMAN (84-156): 3.1e-13: 72.6: 29.11
+	Hs
		967171 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		ELAV3_HUMAN (84-151): 6.6e-13: 72.2: 32.43