Protein: ATR
Serine/threonine-protein kinase MEC1 (EC 2.7.11.1) (ATR homolog) (DNA-damage checkpoint kinase MEC1) (Mitosis entry checkpoint protein 1)

Gene: ATR, MEC1
Organism: Saccharomyces cerevisiae S288C
Interactions: 98
UniProt ID: P38111

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0000722 - telomere maintenance via recombination
GO:0000723 - telomere maintenance
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

793453

LCD1
DNA damage checkpoint protein LCD1

18

1

Small-scale

0.990

High

647754

RFA1
Replication factor A protein 1

12

8

Small-scale

0.761

High

646378

RAD53
Serine/threonine-protein kinase RAD53

11

8

Small-scale

0.758

High

688741

RFA2
Replication factor A protein 2

9

10

Small-scale

0.755

High

688791

RFA3
Replication factor A protein 3

4

0

Small-scale

0.667

High

793413

ATR
Serine/threonine-protein kinase MEC1

1

17

Small-scale

0.647

High

793460

IES4
Ino eighty subunit 4

2

1

Small-scale

0.629

High

793432

DPB11
DNA replication regulator DPB11

2

8

Small-scale

0.626

High

793451

MSH6
DNA mismatch repair protein MSH6

2

6

High-throughput

0.621

High

745179

CDC13
Cell division control protein 13

2

1

Small-scale

0.602

High

763273

SGS1
ATP-dependent helicase SGS1

2

14

Small-scale

0.602

High

644913

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

1

Small-scale

0.589

High

793437

TEL2
Telomere length regulation protein TEL2

2

1

Small-scale

0.584

High

793439

ATG1
Serine/threonine-protein kinase ATG1

2

11

Small-scale

0.584

High

793418

RAD55
DNA repair protein RAD55

2

0

Small-scale

0.577

High

793455

ATG13
Autophagy-related protein 13

2

1

Small-scale

0.576

High

585613

STI1
Heat shock protein STI1

2

9

High-throughput

0.574

High

575276

RAD9
DNA repair protein RAD9

2

0

Small-scale

0.569

High

553605

ERF1
Eukaryotic peptide chain release factor subunit 1

2

1

High-throughput

0.567

High

793440

INO80
Chromatin-remodeling ATPase INO80

1

10

Small-scale

0.561

High

744833

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

3

High-throughput

0.541

High

793414

PAF1
RNA polymerase II-associated protein 1

1

0

Small-scale

0.537

High

793415

LEO1
RNA polymerase-associated protein LEO1

1

0

Small-scale

0.537

High

793438

RTF1
RNA polymerase-associated protein RTF1

1

0

Small-scale

0.537

High

793462

ATG9
Autophagy-related protein 9

1

0

Small-scale

0.537

High

604942

MDHM
Malate dehydrogenase, mitochondrial

1

3

High-throughput

0.536

High

762949

SPT7
SAGA complex subunit SPT7

1

19

High-throughput

0.536

High

793430

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

1

High-throughput

0.536

High

793441

SGF73
SAGA complex subunit SGF73

1

6

High-throughput

0.536

High

622354

ACON
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.513

High

672580

YCP4
Flavoprotein-like protein YCP4

1

0

High-throughput

0.513

High

793427

MSL1
U2 small nuclear ribonucleoprotein B''

1

5

High-throughput

0.508

High

448702

SNF1
Carbon catabolite-derepressing protein kinase

1

5

Small-scale

0.501

High

550049

RAP1
DNA-binding protein RAP1

1

1

Small-scale

0.501

High

666173

MEK1
Meiosis-specific serine/threonine-protein kinase MEK1

1

17

Small-scale

0.501

High

793420

DUN1
DNA damage response protein kinase DUN1

1

20

Small-scale

0.501

High

645049

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.493

High

793421

SNF7
Vacuolar-sorting protein SNF7

1

3

High-throughput

0.489

High

793442

IST1
Vacuolar protein sorting-associated protein IST1

1

1

High-throughput

0.489

High

793449

CLU
Clustered mitochondria protein 1

1

2

High-throughput

0.489

High

677676

MRC1
Mediator of replication checkpoint protein 1

1

0

Small-scale

0.480

High

745993

RE114
Meiotic recombination protein REC114

1

0

Small-scale

0.480

High

531306

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.479

High

579247

HSC82
ATP-dependent molecular chaperone HSC82

1

14

High-throughput

0.479

High

643632

SNF2
Transcription regulatory protein SNF2

1

9

Small-scale

0.479

High

670600

SIS1
Protein SIS1

1

7

Small-scale

0.479

High

706869

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

763311

TAF14
Transcription initiation factor TFIID subunit 14

1

6

Small-scale

0.479

High

793417

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2 [Includes: DNA replication nuclease DNA2

1

8

High-throughput

0.479

High

793419

GGC1
Mitochondrial GTP/GDP carrier protein 1

1

4

Small-scale

0.479

High

793428

DSN1
Kinetochore-associated protein DSN1

1

3

High-throughput

0.479

High

793434

MOG1
Nuclear import protein MOG1

1

1

High-throughput

0.479

High

793444

ARP5
Actin-related protein 5

1

2

Small-scale

0.479

High

793445

ARP4
Actin-related protein 4

1

6

Small-scale

0.479

High

793446

CTR9
RNA polymerase-associated protein CTR9

1

1

Small-scale

0.479

High

793447

NHP10
Non-histone protein 10

1

7

Small-scale

0.479

High

793452

RUVB1
RuvB-like protein 1

1

19

Small-scale

0.479

High

793457

CDC73
Cell division control protein 73

1

2

Small-scale

0.479

High

793458

ASA1
ASTRA-associated protein 1

1

1

Small-scale

0.479

High

793461

HFI1
SAGA complex subunit HFI1

1

2

Small-scale

0.479

High

793465

IES3
Ino eighty subunit 3

1

1

Small-scale

0.479

High

793466

ARP8
Actin-like protein ARP8

1

2

Small-scale

0.479

High

793468

RUVB2
RuvB-like protein 2

1

19

Small-scale

0.479

High

478410

EI2BG
Translation initiation factor eIF2B subunit gamma

1

3

High-throughput

0.470

High

793416

BZZ1
Protein BZZ1

1

1

High-throughput

0.470

High

793448

THADA
tRNA

1

1

High-throughput

0.470

High

793467

LAS17
Proline-rich protein LAS17

1

4

High-throughput

0.470

High

743834

IES6
Chromatin-remodeling complex subunit IES6

1

0

Small-scale

0.458

High

793423

IES5
Ino eighty subunit 5

1

0

Small-scale

0.458

High

793425

IES2
Ino eighty subunit 2

1

0

Small-scale

0.458

High

793429

IES1
Ino eighty subunit 1

1

0

Small-scale

0.458

High

793433

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.458

High

392599

HSP82
ATP-dependent molecular chaperone HSP82

1

14

High-throughput

0.445

High

481592

HSP73
Heat shock protein SSA3

1

12

High-throughput

0.445

High

510421

HSP77
Import motor subunit, mitochondrial

1

8

High-throughput

0.445

High

523696

HSP71
Heat shock protein SSA1

1

12

High-throughput

0.445

High

526478

HSP72
Heat shock protein SSA2

1

12

High-throughput

0.445

High

544576

SSB1
Ribosome-associated molecular chaperone SSB1

1

11

High-throughput

0.445

High

675929

MAS5
Mitochondrial protein import protein MAS5

1

8

High-throughput

0.445

High

726957

HS104
Heat shock protein 104

1

6

High-throughput

0.445

High

741415

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

752164

HSP78
Heat shock protein 78, mitochondrial

1

6

High-throughput

0.445

High

793422

HSP7E
Heat shock protein SSC3, mitochondrial

1

8

High-throughput

0.445

High

793424

SSB2
Ribosome-associated molecular chaperone SSB2

1

11

High-throughput

0.445

High

793426

DJP1
DnaJ-like protein 1

1

5

High-throughput

0.445

High

793436

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

9

High-throughput

0.445

High

793443

APJ1
J domain-containing protein APJ1

1

8

High-throughput

0.445

High

793459

VAM6
Vacuolar morphogenesis protein 6

1

4

High-throughput

0.437

High

757735

PIN4
RNA-binding protein PIN4

1

0

Small-scale

0.426

High

793463

SMT3
Ubiquitin-like protein SMT3

1

4

Small-scale

0.408

High

793431

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.407

High

793435

PFD3
Prefoldin subunit 3

1

1

High-throughput

0.407

High

793456

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

6

High-throughput

0.407

High

793464

HSP42
Heat shock protein 42

1

2

High-throughput

0.407

High

705167

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.249

Low

793450

BUL2
Ubiquitin ligase-binding protein BUL2

1

0

Small-scale

0.249

Low

793454

HSP31
Glutathione-independent glyoxalase HSP31

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025