HitPredict

Interactor 1: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Interactor 2: TCPB (P78371)
T-complex protein 1 subunit beta (TCP-1-beta) (EC 3.6.1.-) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2)
Gene: CCT2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.641

Property	Details
Experiments	31980649, 34941261, unassigned2173
Identification Methods	affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 480 Hs			1 535
+	Hs
		728403 AKT1_HUMAN (1-480): 0: 589: 100.00		TCPH_HUMAN (4-532): 0: 591: 34.08
+	Hs
		728112 AKT1_HUMAN (1-480): 0: 589: 100.00		TCPG_HUMAN (3-532): 0: 561: 28.33
+	Hs
		610541 AKT1_HUMAN (1-480): 0: 589: 100.00		TCPA_HUMAN (5-533): 0: 541: 34.30
+	Hs
		728109 AKT1_HUMAN (1-480): 0: 589: 100.00		TCPE_HUMAN (1-528): 0: 541: 32.29
+	Dm
		1303767 AKT1_DROME (3-474): 0: 526: 60.37		Q9W392_DROME (4-535): 0: 568: 70.73
+	Dm
		1303727 AKT1_DROME (3-474): 0: 526: 60.37		Q9VHL2_DROME (5-525): 0: 554: 31.75
+	Hs
		1407611 KS6B2_HUMAN (129-479): 2.15e-148: 434: 42.25		TCPH_HUMAN (4-532): 0: 591: 34.08
+	Hs
		1007322 KS6B2_HUMAN (129-479): 2.15e-148: 434: 42.25		TCPB_HUMAN (1-535): 0: 586: 100.00
+	Hs
		1407580 SGK2_HUMAN (122-475): 1.93e-147: 427: 47.75		TCPH_HUMAN (4-532): 0: 591: 34.08
+	Hs
		605635 KAPCA_HUMAN (138-445): 7.79e-145: 420: 42.53		TCPB_HUMAN (1-535): 0: 586: 100.00
+	Hs
		882204 KS6B2_HUMAN (129-479): 2.15e-148: 434: 42.25		TCPG_HUMAN (3-532): 0: 561: 28.33
+	Hs
		882171 SGK2_HUMAN (122-475): 1.93e-147: 427: 47.75		TCPG_HUMAN (3-532): 0: 561: 28.33
+	Hs
		610928 KS6B2_HUMAN (129-479): 2.15e-148: 434: 42.25		TCPA_HUMAN (5-533): 0: 541: 34.30
+	Hs
		876211 KS6B2_HUMAN (129-479): 2.15e-148: 434: 42.25		TCPE_HUMAN (1-528): 0: 541: 32.29
+	Hs
		610898 SGK2_HUMAN (122-475): 1.93e-147: 427: 47.75		TCPA_HUMAN (5-533): 0: 541: 34.30
+	Hs
		876180 SGK2_HUMAN (122-475): 1.93e-147: 427: 47.75		TCPE_HUMAN (1-528): 0: 541: 32.29
+	Hs
		605596 KAPCA_HUMAN (138-445): 7.79e-145: 420: 42.53		TCPE_HUMAN (1-528): 0: 541: 32.29
+	Hs
		876110 SGK3_HUMAN (149-447): 5.29e-100: 310: 51.00		TCPE_HUMAN (1-528): 0: 541: 32.29
+	Dm
		554092 AKT1_DROME (3-474): 0: 526: 60.37		TCPA_DROME (1-528): 7.53e-82: 267: 34.55