HitPredict

Interactor 1: MYH11 (P35749)
Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC)
Gene: MYH11

Interactor 2: MYL6 (P60660)
Myosin light polypeptide 6 (17 kDa myosin light chain) (LC17) (Myosin light chain 3) (MLC-3) (Myosin light chain alkali 3) (Myosin light chain A3) (Smooth muscle and nonmuscle myosin light chain alkali 6)
Gene: MYL6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	26496610, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000146 - microfilament motor activity GO:0005829 - cytosol GO:0008307 - structural constituent of muscle GO:0016460 - myosin II complex GO:0070062 - extracellular exosome
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1972 Hs			1 151
+	Ce
		104561 G5EBY3_CAEEL (1-1945): 0: 1308: 45.00		CALM_CAEEL (5-77): 2.09e-11: 59.8: 30.14
+	Hs
		409452 MYH10_HUMAN (885-1971): 1.62e-63: 243: 19.36		MYL1_HUMAN (3-150): 1.84e-56: 176: 74.32
+	Hs
		441665 MYH9_HUMAN (885-1972): 1.2e-64: 246: 17.87		MYL3_HUMAN (3-150): 2.39e-55: 173: 73.33
+	Hs
		441666 MYH10_HUMAN (885-1971): 1.62e-63: 243: 19.36		MYL3_HUMAN (3-150): 2.39e-55: 173: 73.33
+	Gg
		361265 MYH11_CHICK (986-1972): 8.25e-63: 240: 18.85		MYL6_CHICK (1-151): 1.02e-51: 162: 89.40
+	Hs
		441674 MYH14_HUMAN (885-1970): 1.8e-56: 219: 17.79		MYL3_HUMAN (3-150): 2.39e-55: 173: 73.33
+	Hs
		538642 MYH9_HUMAN (885-1972): 1.2e-64: 246: 17.87		MYL6B_HUMAN (3-150): 2.63e-42: 141: 81.76
+	Hs
		538643 MYH10_HUMAN (885-1971): 1.62e-63: 243: 19.36		MYL6B_HUMAN (3-150): 2.63e-42: 141: 81.76
+	Hs
		724737 MYH9_HUMAN (885-1972): 1.2e-64: 246: 17.87		MYL6_HUMAN (1-151): 9.61e-42: 137: 100.00
+	Hs
		725124 MYH10_HUMAN (885-1971): 1.62e-63: 243: 19.36		MYL6_HUMAN (1-151): 9.61e-42: 137: 100.00
+	Ce
		522310 MYO3_CAEEL (1017-1972): 8.73e-62: 237: 17.97		MLE_CAEEL (12-151): 6.35e-36: 123: 46.43
+	Hs
		538680 MYH14_HUMAN (885-1970): 1.8e-56: 219: 17.79		MYL6B_HUMAN (3-150): 2.63e-42: 141: 81.76
+	Hs
		891551 MYH14_HUMAN (885-1970): 1.8e-56: 219: 17.79		MYL6_HUMAN (1-151): 9.61e-42: 137: 100.00
+	Dm
		870145 MYSN_DROME (1442-1972): 4.67e-34: 146: 18.25		MLC2_DROME (1-151): 6.78e-55: 171: 53.64
+	Hs
		648467 MYH9_HUMAN (885-1972): 1.2e-64: 246: 17.87		CALL3_HUMAN (5-77): 1.25e-10: 57.9: 26.03
+	Ce
		361113 MYO4_CAEEL (736-1445): 3.56e-29: 130: 13.59		MLE_CAEEL (12-151): 6.35e-36: 123: 46.43
+	Ce
		361125 MYO1_CAEEL (732-1424): 6.54e-28: 125: 14.23		MLE_CAEEL (12-151): 6.35e-36: 123: 46.43