Protein: PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1-alpha) (PPAR-gamma coactivator 1-alpha) (PPARGC-1-alpha)

Gene: PRGC1, Ppargc1a
Organism: Mus musculus
Interactions: 26
UniProt ID: O70343

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0002021 - response to dietary excess
GO:0003677 - DNA binding
GO:0003712 - transcription coregulator activity
GO:0003713 - transcription coactivator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

266909

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

1

Small-scale

0.661

High

266892

AKT1
RAC-alpha serine/threonine-protein kinase

1

3

Small-scale

0.647

High

266904

EWS
RNA-binding protein EWS

1

1

Small-scale

0.618

High

266900

CDK7
Cyclin-dependent kinase 7

1

0

Small-scale

0.586

High

266891

CEBPB
CCAAT/enhancer-binding protein beta

2

2

Small-scale

0.584

High

266895

PPARG
Peroxisome proliferator-activated receptor gamma

2

20

Small-scale

0.584

High

266893

STF1
Steroidogenic factor 1

1

14

Small-scale

0.573

High

266898

TYY1
Transcriptional repressor protein YY1

1

0

Small-scale

0.564

High

266899

CREB1
Cyclic AMP-responsive element-binding protein 1

2

0

Small-scale

0.559

High

266901

NR1H4
Bile acid receptor

1

20

Small-scale

0.515

High

266905

IRF4
Interferon regulatory factor 4

1

0

Small-scale

0.512

High

147635

ERR1
Steroid hormone receptor ERR1

1

20

Small-scale

0.501

High

266897

ERR3
Estrogen-related receptor gamma

1

20

Small-scale

0.501

High

266903

ERR2
Steroid hormone receptor ERR2

1

20

Small-scale

0.501

High

266906

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

2

Small-scale

0.501

High

266912

NR1H3
Oxysterols receptor LXR-alpha

1

20

High-throughput

0.481

High

59124

PRD16
Histone-lysine N-methyltransferase PRDM16

1

1

Small-scale

0.479

High

266889

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

1

Small-scale

0.479

High

266890

PPARA
Peroxisome proliferator-activated receptor alpha

1

20

Small-scale

0.479

High

266896

HNF4A
Hepatocyte nuclear factor 4-alpha

1

18

Small-scale

0.479

High

266902

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

1

Small-scale

0.479

High

266908

FBXW7
F-box/WD repeat-containing protein 7

1

1

Small-scale

0.479

High

266910

MED1
Mediator of RNA polymerase II transcription subunit 1

1

1

Small-scale

0.479

High

266894

DDIT3
DNA damage-inducible transcript 3 protein

1

0

Small-scale

0.458

High

266907

MBB1A
Myb-binding protein 1A

1

0

Small-scale

0.458

High

266911

PRAF1
Prenylated Rab acceptor protein 1

1

0

Small-scale

0.238

Low


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Last updated: 11Aug2025