HitPredict

Interactor 1: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Interactor 2: SIR4 (Q9Y6E7)
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial (EC 2.3.1.-) (NAD-dependent ADP-ribosyltransferase sirtuin-4) (EC 2.4.2.-) (NAD-dependent protein biotinylase sirtuin-4) (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-4) (EC 2.3.1.286) (Regulatory protein SIR2 homolog 4) (SIR2-like protein 4)
Gene: SIRT4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35512704
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0046889 - positive regulation of lipid biosynthetic process
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 480 Hs			1 314
+	Hs
		728323 AKT1_HUMAN (1-480): 0: 589: 100.00		SIR2_HUMAN (39-296): 1.01e-88: 271: 24.06
+	Hs
		728336 AKT1_HUMAN (1-480): 0: 589: 100.00		SIR6_HUMAN (16-311): 6.4e-89: 271: 27.43
+	Hs
		728377 AKT1_HUMAN (1-480): 0: 589: 100.00		SIR1_HUMAN (28-308): 3e-83: 267: 22.76