Protein: SIR2
NAD-dependent protein deacetylase sirtuin-2 (EC 2.3.1.286) (NAD-dependent protein defatty-acylase sirtuin-2) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2)

Gene: SIR2, SIRT2
Organism: Homo sapiens
Interactions: 158
UniProt ID: Q8IXJ6

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000183 - rDNA heterochromatin formation
GO:0000781 - chromosome, telomeric region
GO:0000792 - heterochromatin
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

998521

H31
Histone H3.1

3

10

Small-scale

0.845

High

884768

SYSC
Serine--tRNA ligase, cytoplasmic

4

3

High-throughput

0.697

High

1085586

FOXO1
Forkhead box protein O1

3

13

Small-scale

0.670

High

1067494

EP300
Histone acetyltransferase p300

3

13

Small-scale

0.670

High

350067

SNAI1
Zinc finger protein SNAI1

3

4

High-throughput

0.667

High

1312372

NUD12
NAD-capped RNA hydrolase NUDT12

3

7

High-throughput

0.667

High

178646

DEGS1
Sphingolipid delta(4)-desaturase DES1

3

0

High-throughput

0.638

High

248602

FADS1
Acyl-CoA

3

0

High-throughput

0.638

High

908030

VAMP7
Vesicle-associated membrane protein 7

3

0

High-throughput

0.638

High

1104356

ORC2
Origin recognition complex subunit 2

3

0

High-throughput

0.638

High

1139338

RB3GP
Rab3 GTPase-activating protein catalytic subunit

3

0

High-throughput

0.638

High

1288195

LYRIC
Protein LYRIC

3

0

High-throughput

0.638

High

1312378

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

3

0

High-throughput

0.638

High

1312380

GPAT1
Glycerol-3-phosphate acyltransferase 1, mitochondrial

3

0

High-throughput

0.638

High

506807

GSTT2
Glutathione S-transferase theta-2B

2

1

High-throughput

0.628

High

547465

DMD
Dystrophin

2

8

High-throughput

0.628

High

721477

GSTT1
Glutathione S-transferase theta-1

2

1

High-throughput

0.628

High

1312362

MOAP1
Modulator of apoptosis 1

2

1

High-throughput

0.628

High

419071

H2A1B
Histone H2A type 1-B/E

1

10

Small-scale

0.618

High

1312346

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

13

Small-scale

0.618

High

1312364

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

13

Small-scale

0.618

High

1312359

KAT2B
Histone acetyltransferase KAT2B

2

14

Small-scale

0.611

High

50114

S22AN
Solute carrier family 22 member 23

2

0

High-throughput

0.602

High

1312392

FZR1
Fizzy-related protein homolog

1

8

Small-scale

0.586

High

1287371

SYVN1
E3 ubiquitin-protein ligase synoviolin

2

3

Small-scale

0.584

High

1312386

HDAC6
Protein deacetylase HDAC6

2

9

Small-scale

0.584

High

1312376

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

4

High-throughput

0.582

High

227609

SPOP
Speckle-type POZ protein

2

0

Small-scale

0.576

High

866468

PA24A
Cytosolic phospholipase A2

1

2

Small-scale

0.573

High

173040

XPO1
Exportin-1

2

9

Small-scale

0.563

High

1086876

CDC20
Cell division cycle protein 20 homolog

1

8

Small-scale

0.561

High

1161319

HIF1A
Hypoxia-inducible factor 1-alpha

1

10

Small-scale

0.561

High

1312395

MORC2
ATPase MORC2

1

2

Small-scale

0.561

High

1055940

RAD51
DNA repair protein RAD51 homolog 1

1

1

High-throughput

0.541

High

1312357

ATRIP
ATR-interacting protein

1

0

Small-scale

0.537

High

251783

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

7

Small-scale

0.536

High

968370

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

5

High-throughput

0.536

High

1045486

TF65
Transcription factor p65

1

7

Small-scale

0.536

High

720721

OXYR
Oxytocin receptor

1

0

High-throughput

0.518

High

254384

CC14B
Dual specificity protein phosphatase CDC14B

1

5

Small-scale

0.515

High

644524

PUR2
Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase

1

3

High-throughput

0.515

High

1312348

K2C78
Keratin, type II cytoskeletal 78

1

4

High-throughput

0.515

High

702404

CYTD
Cystatin-D

1

0

High-throughput

0.513

High

916143

NAR1
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1

1

0

High-throughput

0.513

High

1312350

HORM2
HORMA domain-containing protein 2

1

0

High-throughput

0.513

High

1312353

RP9
Retinitis pigmentosa 9 protein

1

0

High-throughput

0.513

High

667928

CDK2
Cyclin-dependent kinase 2

1

6

Small-scale

0.501

High

912583

GDIR1
Rho GDP-dissociation inhibitor 1

1

1

Small-scale

0.501

High

997022

TBA4A
Tubulin alpha-4A chain

1

3

Small-scale

0.501

High

1028273

MDM2
E3 ubiquitin-protein ligase Mdm2

1

4

Small-scale

0.501

High

1060274

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

1

2

Small-scale

0.501

High

542792

G6PD
Glucose-6-phosphate 1-dehydrogenase

1

0

Small-scale

0.493

High

568670

GYS1
Glycogen [starch] synthase, muscle

1

0

High-throughput

0.493

High

1312371

PHB2
Prohibitin-2

1

0

High-throughput

0.493

High

1312381

RTN4
Reticulon-4

1

0

High-throughput

0.493

High

581689

MYOD1
Myoblast determination protein 1

1

4

Small-scale

0.484

High

209604

SERA
D-3-phosphoglycerate dehydrogenase

1

0

Small-scale

0.480

High

122522

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

1

3

High-throughput

0.479

High

228312

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

1

Small-scale

0.479

High

242225

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

274650

DNJB6
DnaJ homolog subfamily B member 6

1

4

Small-scale

0.479

High

372519

MYC
Myc proto-oncogene protein

1

7

Small-scale

0.479

High

414170

P53
Cellular tumor antigen p53

1

6

High-throughput

0.479

High

424955

ADT2
ADP/ATP translocase 2

1

7

Small-scale

0.479

High

437262

K2C8
Keratin, type II cytoskeletal 8

1

2

High-throughput

0.479

High

475625

K1C19
Keratin, type I cytoskeletal 19

1

1

High-throughput

0.479

High

482157

RET1
Retinol-binding protein 1

1

1

Small-scale

0.479

High

487508

PARP1
Poly [ADP-ribose] polymerase 1

1

6

Small-scale

0.479

High

532744

CH60
60 kDa heat shock protein, mitochondrial

1

5

Small-scale

0.479

High

537475

HSP7C
Heat shock cognate 71 kDa protein

1

6

Small-scale

0.479

High

570492

GFAP
Glial fibrillary acidic protein

1

7

High-throughput

0.479

High

582869

EZRI
Ezrin

1

4

High-throughput

0.479

High

589111

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

606903

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

612694

RL7
Large ribosomal subunit protein uL30

1

1

Small-scale

0.479

High

651377

CBL
E3 ubiquitin-protein ligase CBL

1

5

Small-scale

0.479

High

695894

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

715665

MARCS
Myristoylated alanine-rich C-kinase substrate

1

1

High-throughput

0.479

High

721031

CLIP1
CAP-Gly domain-containing linker protein 1

1

7

High-throughput

0.479

High

728323

AKT1
RAC-alpha serine/threonine-protein kinase

1

3

Small-scale

0.479

High

764386

CTNA1
Catenin alpha-1

1

2

High-throughput

0.479

High

772397

PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

1

1

Small-scale

0.479

High

777518

K22E
Keratin, type II cytoskeletal 2 epidermal

1

3

Small-scale

0.479

High

833310

PERI
Peripherin

1

7

High-throughput

0.479

High

852799

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

2

Small-scale

0.479

High

862286

YAP1
Transcriptional coactivator YAP1

1

7

Small-scale

0.479

High

882765

EFTU
Elongation factor Tu, mitochondrial

1

6

Small-scale

0.479

High

899755

PAPOA
Poly(A) polymerase alpha

1

1

Small-scale

0.479

High

920846

ACLY
ATP-citrate synthase

1

4

Small-scale

0.479

High

936603

ELL
RNA polymerase II elongation factor ELL

1

2

High-throughput

0.479

High

958306

ARP2
Actin-related protein 2

1

2

High-throughput

0.479

High

981575

RAN
GTP-binding nuclear protein Ran

1

1

Small-scale

0.479

High

1038323

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

13

Small-scale

0.479

High

1091428

ANK3
Ankyrin-3

1

4

High-throughput

0.479

High

1097946

CBLB
E3 ubiquitin-protein ligase CBL-B

1

7

Small-scale

0.479

High

1101850

SKP2
S-phase kinase-associated protein 2

1

6

Small-scale

0.479

High

1104214

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

9

High-throughput

0.479

High

1107899

SQSTM
Sequestosome-1

1

4

High-throughput

0.479

High

1109471

ATR
Serine/threonine-protein kinase ATR

1

9

Small-scale

0.479

High

1114929

CUL4A
Cullin-4A

1

5

High-throughput

0.479

High

1156539

CCDC6
Coiled-coil domain-containing protein 6

1

7

High-throughput

0.479

High

1159996

SRSF7
Serine/arginine-rich splicing factor 7

1

3

Small-scale

0.479

High

1203189

ODFP2
Outer dense fiber protein 2

1

8

High-throughput

0.479

High

1228432

FTM
Protein fantom

1

8

High-throughput

0.479

High

1246876

RICTR
Rapamycin-insensitive companion of mTOR

1

2

High-throughput

0.479

High

1312347

AHI1
Jouberin

1

5

High-throughput

0.479

High

1312352

DNJB8
DnaJ homolog subfamily B member 8

1

4

Small-scale

0.479

High

1312354

FBF1
Fas-binding factor 1

1

7

High-throughput

0.479

High

1312358

KAT2A
Histone acetyltransferase KAT2A

1

17

Small-scale

0.479

High

1312360

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

9

High-throughput

0.479

High

1312366

SCLT1
Sodium channel and clathrin linker 1

1

9

High-throughput

0.479

High

1312368

CEP89
Centrosomal protein of 89 kDa

1

7

High-throughput

0.479

High

1312369

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

1312373

RIOK1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

1312374

TINF2
TERF1-interacting nuclear factor 2

1

1

High-throughput

0.479

High

1312377

UNK
RING finger protein unkempt homolog

1

2

High-throughput

0.479

High

1312387

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1312388

TBK1
Serine/threonine-protein kinase TBK1

1

4

High-throughput

0.479

High

1312389

ANC2
Anaphase-promoting complex subunit 2

1

7

High-throughput

0.479

High

1312390

ING1
Inhibitor of growth protein 1

1

8

Small-scale

0.479

High

1312391

FBXL4
F-box/LRR-repeat protein 4

1

6

High-throughput

0.479

High

1312393

FBW1A
F-box/WD repeat-containing protein 1A

1

6

High-throughput

0.479

High

1312394

MTCH2
Mitochondrial carrier homolog 2

1

5

High-throughput

0.479

High

336986

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

0

Small-scale

0.458

High

347798

BAG3
BAG family molecular chaperone regulator 3

1

0

Small-scale

0.458

High

464180

TPM2
Tropomyosin beta chain

1

0

Small-scale

0.458

High

974422

SMD1
Small nuclear ribonucleoprotein Sm D1

1

0

Small-scale

0.458

High

977750

ACTA
Actin, aortic smooth muscle

1

0

Small-scale

0.458

High

1110649

DCTN2
Dynactin subunit 2

1

0

High-throughput

0.458

High

1111601

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.458

High

1117057

RUNX3
Runt-related transcription factor 3

1

0

Small-scale

0.458

High

1126065

GCKR
Glucokinase regulatory protein

1

0

Small-scale

0.458

High

1233331

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

1289446

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1312351

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.458

High

1312356

TPC12
Trafficking protein particle complex subunit 12

1

0

High-throughput

0.458

High

1312363

ENTR1
Endosome-associated-trafficking regulator 1

1

0

High-throughput

0.458

High

1312367

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

1312370

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.458

High

1312375

DERL1
Derlin-1

1

0

High-throughput

0.458

High

1312383

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.458

High

1312384

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

1312382

BMP2K
BMP-2-inducible protein kinase

1

2

Small-scale

0.457

High

530054

TAU
Microtubule-associated protein tau

1

5

Small-scale

0.445

High

1235716

SCMC2
Mitochondrial adenyl nucleotide antiporter SLC25A25

1

4

High-throughput

0.445

High

1312349

FBXL6
F-box/LRR-repeat protein 6

1

6

High-throughput

0.437

High

1312385

SEP10
Septin-10

1

1

High-throughput

0.437

High

1312355

SCFD2
Sec1 family domain-containing protein 2

3

0

High-throughput

0.347

High

1233887

K0930
Uncharacterized protein KIAA0930

2

0

High-throughput

0.328

High

1312379

MANS1
MANSC domain-containing protein 1

2

0

High-throughput

0.328

High

106237

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

139922

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

768604

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

1027070

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.249

Low

1312361

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.249

Low

1312365

BORC6
BLOC-1-related complex subunit 6

1

0

High-throughput

0.249

Low

1070446

ZNFS1
Putative uncharacterized protein ZNF252P-AS1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025