HitPredict

Interactor 1: PARP (P35875)
Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.30) (NAD(+) ADP-ribosyltransferase) (ADPRT) (Poly[ADP-ribose] synthase) (Protein ADP-ribosyltransferase Parp) (EC 2.4.2.-)
Gene: PARP

Interactor 2: H2A (P84051)
Histone H2A
Gene: His2A

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24508391
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005694 - chromosome GO:0005700 - polytene chromosome GO:0006325 - chromatin organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 994 Dm			1 124
+	Hs
		555678 PARP2_HUMAN (439-992): 0: 627: 36.51		H2AX_HUMAN (1-120): 6.84e-62: 187: 90.91
+	Hs
		1087127 PARP2_HUMAN (439-992): 0: 627: 36.51		H2A2C_HUMAN (1-122): 1.62e-61: 185: 89.43
+	Hs
		1151393 PARP2_HUMAN (439-992): 0: 627: 36.51		H2A2A_HUMAN (1-122): 1.75e-61: 185: 89.43
+	Hs
		391953 PARP2_HUMAN (439-992): 0: 627: 36.51		H2A1B_HUMAN (1-122): 3.57e-61: 185: 88.62
+	Hs
		470599 PARP2_HUMAN (439-992): 0: 627: 36.51		H2A1_HUMAN (1-122): 3.27e-61: 185: 89.43
+	Hs
		555353 DNLI3_HUMAN (4-107): 1.92e-28: 125: 21.05		H2AX_HUMAN (1-120): 6.84e-62: 187: 90.91
+	Hs
		391601 DNLI3_HUMAN (4-107): 1.92e-28: 125: 21.05		H2A1B_HUMAN (1-122): 3.57e-61: 185: 88.62
+	Hs
		470301 DNLI3_HUMAN (4-107): 1.92e-28: 125: 21.05		H2A1_HUMAN (1-122): 3.27e-61: 185: 89.43
+	Hs
		836737 DNLI3_HUMAN (4-107): 1.92e-28: 125: 21.05		H2A2C_HUMAN (1-122): 1.62e-61: 185: 89.43
+	Hs
		555522 ZCCHV_HUMAN (632-988): 9.55e-26: 116: 13.86		H2AX_HUMAN (1-120): 6.84e-62: 187: 90.91
+	Hs
		470434 ZCCHV_HUMAN (632-988): 9.55e-26: 116: 13.86		H2A1_HUMAN (1-122): 3.27e-61: 185: 89.43
+	Hs
		455622 PARP1_HUMAN (103-513): 4.94e-19: 94.9: 15.74		H2A2B_HUMAN (1-122): 1.38e-62: 188: 90.24
+	Hs
		455818 PARP1_HUMAN (103-513): 4.94e-19: 94.9: 15.74		H2AJ_HUMAN (1-123): 2.21e-62: 188: 90.32
+	Hs
		455054 PARP1_HUMAN (103-513): 4.94e-19: 94.9: 15.74		H2AX_HUMAN (1-120): 6.84e-62: 187: 90.91
+	Hs
		455802 PARP1_HUMAN (103-513): 4.94e-19: 94.9: 15.74		H2A1J_HUMAN (1-122): 4.6e-62: 187: 89.43
+	Hs
		391516 PARP1_HUMAN (103-513): 4.94e-19: 94.9: 15.74		H2A1B_HUMAN (1-122): 3.57e-61: 185: 88.62
+	Hs
		455012 PARP1_HUMAN (103-513): 4.94e-19: 94.9: 15.74		H2A1_HUMAN (1-122): 3.27e-61: 185: 89.43
+	Hs
		455554 PARP1_HUMAN (103-513): 4.94e-19: 94.9: 15.74		H2A2A_HUMAN (1-122): 1.75e-61: 185: 89.43
+	Hs
		455732 PARP1_HUMAN (103-513): 4.94e-19: 94.9: 15.74		H2A1C_HUMAN (1-122): 2.09e-61: 185: 90.24
+	Hs
		1087011 PAR10_HUMAN (783-987): 6.43e-19: 94.6: 15.35		H2A2C_HUMAN (1-122): 1.62e-61: 185: 89.43