Protein: MED7
Mediator of RNA polymerase II transcription subunit 7 (Mediator complex subunit 7)

Gene: MED7
Organism: Saccharomyces cerevisiae S288C
Interactions: 102
UniProt ID: Q08278

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0016592 - mediator complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

994568

MED4
Mediator of RNA polymerase II transcription subunit 4

16

1

Small-scale

0.984

High

814169

MED21
Mediator of RNA polymerase II transcription subunit 21

15

1

Small-scale

0.983

High

693569

MED17
Mediator of RNA polymerase II transcription subunit 17

13

2

Small-scale

0.978

High

751479

MED31
Mediator of RNA polymerase II transcription subunit 31

9

4

Small-scale

0.971

High

581384

MED14
Mediator of RNA polymerase II transcription subunit 14

10

3

Small-scale

0.969

High

748117

MED8
Mediator of RNA polymerase II transcription subunit 8

10

2

Small-scale

0.967

High

986568

MED10
Mediator of RNA polymerase II transcription subunit 10

9

6

Small-scale

0.967

High

626044

MED19
Mediator of RNA polymerase II transcription subunit 19

6

0

Small-scale

0.881

High

693943

MED18
Mediator of RNA polymerase II transcription subunit 18

16

1

Small-scale

0.761

High

375528

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

3

Small-scale

0.754

High

686868

MED16
Mediator of RNA polymerase II transcription subunit 16

8

1

Small-scale

0.746

High

754287

MED6
Mediator of RNA polymerase II transcription subunit 6

8

4

Small-scale

0.744

High

994567

MED1
Mediator of RNA polymerase II transcription subunit 1

11

0

Small-scale

0.721

High

704162

MED9
Mediator of RNA polymerase II transcription subunit 9

9

0

Small-scale

0.720

High

586342

MED15
Mediator of RNA polymerase II transcription subunit 15

8

0

Small-scale

0.714

High

859242

MED5
Mediator of RNA polymerase II transcription subunit 5

7

0

Small-scale

0.713

High

994565

MED2
Mediator of RNA polymerase II transcription subunit 2

8

0

Small-scale

0.713

High

994571

MED11
Mediator of RNA polymerase II transcription subunit 11

7

0

Small-scale

0.710

High

693608

MED22
Mediator of RNA polymerase II transcription subunit 22

7

0

Small-scale

0.708

High

710277

MED20
Mediator of RNA polymerase II transcription subunit 20

6

0

Small-scale

0.696

High

636002

SRB8
Mediator of RNA polymerase II transcription subunit 12

4

3

Small-scale

0.691

High

772524

MED3
Mediator of RNA polymerase II transcription subunit 3

6

0

Small-scale

0.686

High

758028

SSN2
Mediator of RNA polymerase II transcription subunit 13

5

0

Small-scale

0.684

High

760598

SSN3
Meiotic mRNA stability protein kinase SSN3

3

4

Small-scale

0.646

High

970410

ADA2
Transcriptional adapter 2

2

3

High-throughput

0.621

High

994563

MED7
Mediator of RNA polymerase II transcription subunit 7

1

1

Small-scale

0.618

High

367004

HSP82
ATP-dependent molecular chaperone HSP82

2

2

High-throughput

0.608

High

558294

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

2

Small-scale

0.584

High

713184

FAB1
1-phosphatidylinositol 3-phosphate 5-kinase FAB1

2

2

High-throughput

0.567

High

858578

TAF6
Transcription initiation factor TFIID subunit 6

2

0

High-throughput

0.563

High

972924

IMA1
Importin subunit alpha

2

0

High-throughput

0.563

High

715744

TAF14
Transcription initiation factor TFIID subunit 14

2

0

Small-scale

0.559

High

492651

HSP71
Heat shock protein SSA1

2

3

High-throughput

0.552

High

512988

SSB1
Ribosome-associated molecular chaperone SSB1

2

3

High-throughput

0.552

High

485847

IF4A
ATP-dependent RNA helicase eIF4A

2

2

High-throughput

0.537

High

743198

BOB1
Protein BOB1

1

1

High-throughput

0.494

High

629401

BUD31
Pre-mRNA-splicing factor BUD31

1

0

High-throughput

0.486

High

355674

H2B1
Histone H2B.1

1

0

Small-scale

0.480

High

356765

H4
Histone H4

1

0

Small-scale

0.480

High

994450

THP1
Nuclear mRNA export protein THP1

1

0

Small-scale

0.480

High

577183

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

1

3

Small-scale

0.479

High

603342

SNF2
Transcription regulatory protein SNF2

1

1

Small-scale

0.479

High

696174

SWI3
SWI/SNF complex subunit SWI3

1

3

Small-scale

0.479

High

696265

STH1
Nuclear protein STH1/NPS1

1

1

Small-scale

0.479

High

698694

RSC7
Chromatin structure-remodeling complex subunit RSC7

1

1

Small-scale

0.479

High

797013

SWP82
SWI/SNF global transcription activator complex subunit SWP82

1

1

Small-scale

0.479

High

797964

RSC8
Chromatin structure-remodeling complex protein RSC8

1

3

Small-scale

0.479

High

814156

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

3

High-throughput

0.479

High

863668

SNF12
Transcription regulatory protein SNF12

1

2

Small-scale

0.479

High

986314

SFH1
Chromatin structure-remodeling complex subunit SFH1

1

2

Small-scale

0.479

High

381578

GAL4
Regulatory protein GAL4

1

0

Small-scale

0.460

High

452129

SWI1
SWI/SNF chromatin-remodeling complex subunit SWI1

1

0

Small-scale

0.458

High

566241

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.458

High

579819

SNF6
Transcription regulatory protein SNF6

1

0

Small-scale

0.458

High

663515

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

716517

SPT21
Protein SPT21

1

0

High-throughput

0.458

High

728329

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

805136

SAC3
Nuclear mRNA export protein SAC3

1

0

Small-scale

0.458

High

812141

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

861544

RT102
Regulator of Ty1 transposition protein 102

1

0

Small-scale

0.458

High

862607

SSU72
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

1

0

Small-scale

0.458

High

983299

ARP9
Actin-like protein ARP9

1

0

Small-scale

0.458

High

993144

RSC58
Chromatin structure-remodeling complex protein RSC58

1

0

Small-scale

0.458

High

994564

TAF10
Transcription initiation factor TFIID subunit 10

1

0

High-throughput

0.458

High

994566

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

994569

ARP7
Actin-related protein 7

1

0

Small-scale

0.458

High

994570

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.458

High

743715

HMT1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.457

High

495140

HSP72
Heat shock protein SSA2

1

3

High-throughput

0.445

High

695672

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

754764

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

High-throughput

0.445

High

769657

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

High-throughput

0.445

High

748561

ARPC1
Actin-related protein 2/3 complex subunit 1

1

1

Small-scale

0.437

High

969431

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

2

Small-scale

0.437

High

987357

CORO
Coronin-like protein

1

1

Small-scale

0.437

High

987571

RSC2
Chromatin structure-remodeling complex subunit RSC2

1

3

Small-scale

0.437

High

454483

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.426

High

975985

GCN5
Histone acetyltransferase GCN5

1

0

High-throughput

0.426

High

544526

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.407

High

687495

EF2
Elongation factor 2

1

2

High-throughput

0.407

High

760833

TCPG
T-complex protein 1 subunit gamma

1

1

High-throughput

0.407

High

785247

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.407

High

333925

ADH1
Alcohol dehydrogenase 1

2

0

High-throughput

0.307

High

340755

PGK
Phosphoglycerate kinase

2

0

High-throughput

0.307

High

343031

ENO2
Enolase 2

2

0

High-throughput

0.307

High

537490

ALF
Fructose-bisphosphate aldolase

2

0

High-throughput

0.307

High

774833

PUP1
PUP1 protein homolog

2

0

High-throughput

0.307

High

797687

FAR7
Factor arrest protein 7

1

0

High-throughput

0.282

High

534851

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.279

Low

669519

FNTA
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

1

0

High-throughput

0.265

Low

859681

SP105
Spindle pole body component SPC105

1

0

High-throughput

0.251

Low

689388

ARP2
Actin-related protein 2

1

0

Small-scale

0.249

Low

703312

ARPC4
Actin-related protein 2/3 complex subunit 4

1

0

Small-scale

0.249

Low

775038

ARPC5
Actin-related protein 2/3 complex subunit 5

1

0

Small-scale

0.249

Low

811967

ARP3
Actin-related protein 3

1

0

Small-scale

0.249

Low

864469

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

Small-scale

0.249

Low

985317

ARPC3
Actin-related protein 2/3 complex subunit 3

1

0

Small-scale

0.249

Low

696601

SEC17
Alpha-soluble NSF attachment protein

1

0

High-throughput

0.238

Low

748398

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.238

Low

667291

RL8B
Large ribosomal subunit protein eL8B

1

0

High-throughput

0.232

Low

837370

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024