HitPredict

Interactor 1: K22E (P35908)
Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2)
Gene: KRT2

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	31980649, 19380743, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 639 Hs			1 217
+	Hs
		409046 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		444533 K2C7_HUMAN (86-542): 4.82e-131: 395: 52.62		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		380590 K2C1_HUMAN (143-509): 1.63e-112: 353: 71.94		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924679 K2C73_HUMAN (1-598): 8.9e-92: 296: 51.00		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924470 KRT85_HUMAN (5-491): 4.47e-87: 282: 45.59		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924576 KRT81_HUMAN (72-491): 2.86e-87: 282: 48.46		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		213936 KRT86_HUMAN (72-557): 8.74e-87: 281: 44.35		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924469 KRT83_HUMAN (83-491): 2.11e-86: 280: 49.02		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		531551 K2C5_HUMAN (1-494): 7.49e-82: 271: 61.48		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		359480 K2C6A_HUMAN (5-510): 8.33e-78: 259: 61.22		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Mm
		1141145 Q8BIS2_MOUSE (16-503): 1.61e-66: 229: 53.69		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Mm
		1060206 Q148Q7_MOUSE (16-503): 2.87e-66: 228: 53.69		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Mm
		403456 K2C5_MOUSE (1-506): 7.46e-78: 260: 59.22		SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		924895 KRT82_HUMAN (224-621): 6.34e-11: 67.2: 14.56		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00