HitPredict

Interactor 1: VGFR3 (P35916)
Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4)
Gene: FLT4

Interactor 2: DUS19 (Q8WTR2)
Dual specificity protein phosphatase 19 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity phosphatase TS-DSP1) (Low molecular weight dual specificity phosphatase 3) (LMW-DSP3) (Protein phosphatase SKRP1) (Stress-activated protein kinase pathway-regulating phosphatase 1) (SAPK pathway-regulating phosphatase 1)
Gene: DUSP19

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	28065597
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0043410 - positive regulation of MAPK cascade GO:0046330 - positive regulation of JNK cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1363 Hs			1 217
+	Hs
		729673 VGFR2_HUMAN (1-1346): 0: 879: 42.21		DUS19_HUMAN (1-217): 8.11e-89: 262: 100.00
+	Hs
		729674 VGFR2_HUMAN (1-1346): 0: 879: 42.21		STYX_HUMAN (42-215): 5.73e-57: 181: 29.83
+	Hs
		1072555 EPHA7_HUMAN (392-1212): 1.3e-153: 492: 14.29		DUS18_HUMAN (49-216): 1.14e-60: 189: 27.98
+	Hs
		665410 EPHA3_HUMAN (386-1200): 1.47e-152: 489: 14.15		DUS18_HUMAN (49-216): 1.14e-60: 189: 27.98
+	Hs
		872488 EPHA5_HUMAN (373-1199): 1.28e-153: 493: 13.44		DUS21_HUMAN (58-216): 7.05e-59: 185: 29.56
+	Hs
		665430 EPHA3_HUMAN (386-1200): 1.47e-152: 489: 14.15		DUS21_HUMAN (58-216): 7.05e-59: 185: 29.56
+	Hs
		1072561 EPHA7_HUMAN (392-1212): 1.3e-153: 492: 14.29		STYX_HUMAN (42-215): 5.73e-57: 181: 29.83
+	Hs
		665415 EPHA3_HUMAN (386-1200): 1.47e-152: 489: 14.15		STYX_HUMAN (42-215): 5.73e-57: 181: 29.83
+	Hs
		1072585 EPHA7_HUMAN (392-1212): 1.3e-153: 492: 14.29		DUS26_HUMAN (63-205): 1.64e-55: 177: 30.20
+	Hs
		1031156 PTK7_HUMAN (2-331): 1.72e-50: 197: 14.16		DUS19_HUMAN (1-217): 8.11e-89: 262: 100.00
+	Hs
		434278 RET_HUMAN (801-1176): 1.25e-74: 273: 40.63		DUS26_HUMAN (63-205): 1.64e-55: 177: 30.20
+	Hs
		304956 PTK7_HUMAN (2-331): 1.72e-50: 197: 14.16		DUS14_HUMAN (62-216): 2.26e-65: 202: 30.32
+	Hs
		1031154 PTK7_HUMAN (2-331): 1.72e-50: 197: 14.16		DUS18_HUMAN (49-216): 1.14e-60: 189: 27.98
+	Hs
		1031172 PTK7_HUMAN (2-331): 1.72e-50: 197: 14.16		DUS21_HUMAN (58-216): 7.05e-59: 185: 29.56
+	Hs
		1031157 PTK7_HUMAN (2-331): 1.72e-50: 197: 14.16		STYX_HUMAN (42-215): 5.73e-57: 181: 29.83
+	Hs
		1031168 PTK7_HUMAN (2-331): 1.72e-50: 197: 14.16		DUS15_HUMAN (69-200): 4.44e-55: 178: 37.12
+	Hs
		1031165 PTK7_HUMAN (2-331): 1.72e-50: 197: 14.16		DUS26_HUMAN (63-205): 1.64e-55: 177: 30.20
+	Hs
		1031139 PTK7_HUMAN (2-331): 1.72e-50: 197: 14.16		DUS29_HUMAN (64-204): 1.58e-53: 172: 30.20
+	Hs
		499276 KIT_HUMAN (4-426): 3.17e-22: 106: 11.67		STYX_HUMAN (42-215): 5.73e-57: 181: 29.83
+	Hs
		169190 MUSK_HUMAN (2-152): 6.12e-16: 85.4: 13.25		STYX_HUMAN (42-215): 5.73e-57: 181: 29.83