HitPredict

Interactor 1: VGFR2 (P35968)
Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)
Gene: KDR

Interactor 2: SH22A (Q9NP31)
SH2 domain-containing protein 2A (SH2 domain-containing adapter protein) (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein)
Gene: SH2D2A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	1.00	0.681

Property	Details
Experiments	22689825
Identification Methods	unspecified method, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0001525 - angiogenesis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1356 Hs			1 389
+	Hs
		522825 VGFR2_HUMAN (1-1356): 0: 1028: 100.00		SRC_HUMAN (21-280): 1.14e-48: 174: 17.73
+	Hs
		729636 VGFR2_HUMAN (1-1356): 0: 1028: 100.00		GRB2_HUMAN (56-256): 4.42e-50: 169: 15.71
+	Hs
		412060 VGFR2_HUMAN (1-1356): 0: 1028: 100.00		FYN_HUMAN (38-280): 1.65e-45: 165: 15.67
+	Dm
		112231 M9MRE1_DROME (31-1354): 0: 608: 21.17		SRC42_DROME (8-210): 2.2e-46: 167: 19.37
+	Dm
		112214 M9MRE1_DROME (31-1354): 0: 608: 21.17		GRAP_DROME (67-177): 4.19e-23: 97.9: 20.00
+	Mm
		403421 RET_MOUSE (809-1201): 1.5e-77: 281: 41.01		SRC_MOUSE (4-280): 1.66e-51: 182: 17.73
+	Rn
		595729 PGFRA_RAT (11-545): 1.25e-56: 217: 19.17		LYN_RAT (9-284): 7.16e-47: 168: 14.58
+	Hs
		452342 PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45		VAV_HUMAN (6-256): 4.43e-48: 176: 15.77
+	Hs
		452338 PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45		SRC_HUMAN (21-280): 1.14e-48: 174: 17.73
+	Hs
		452375 PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45		VAV2_HUMAN (6-258): 3.29e-46: 171: 13.22
+	Hs
		557065 PGFRA_HUMAN (11-545): 1.02e-53: 207: 19.71		CRKL_HUMAN (95-347): 5.6e-49: 169: 21.76
+	Hs
		557088 PGFRA_HUMAN (11-545): 1.02e-53: 207: 19.71		GRB2_HUMAN (56-256): 4.42e-50: 169: 15.71
+	Hs
		452385 PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45		GRB2_HUMAN (56-256): 4.42e-50: 169: 15.71
+	Hs
		433221 PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45		YES_HUMAN (7-280): 2.56e-46: 168: 16.56
+	Hs
		411953 PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45		FYN_HUMAN (38-280): 1.65e-45: 165: 15.67
+	Hs
		557064 PGFRA_HUMAN (11-545): 1.02e-53: 207: 19.71		CRK_HUMAN (95-341): 6.51e-46: 161: 17.28
+	Hs
		452371 PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45		CRK_HUMAN (95-341): 6.51e-46: 161: 17.28
+	Hs
		411962 KIT_HUMAN (15-545): 5.99e-49: 192: 17.46		FYN_HUMAN (38-280): 1.65e-45: 165: 15.67
+	Hs
		411567 KIT_HUMAN (15-545): 5.99e-49: 192: 17.46		LCK_HUMAN (22-210): 4.42e-45: 164: 17.31
+	Hs
		275165 KIT_HUMAN (15-545): 5.99e-49: 192: 17.46		GRAP2_HUMAN (68-220): 2.23e-45: 160: 21.66