HitPredict

Interactor 1: PDE1A (P54750)
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Cam-PDE 1A) (EC 3.1.4.17) (61 kDa Cam-PDE) (hCam-1)
Gene: PDE1A

Interactor 2: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	16959763
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 535 Hs			1 245
+	Mm
		989973 PDE1A_MOUSE (1-521): 0: 744: 93.86		1433Z_MOUSE (1-245): 3.49e-145: 407: 99.59
+	Mm
		989951 PDE1B_MOUSE (3-520): 0: 653: 59.42		1433Z_MOUSE (1-245): 3.49e-145: 407: 99.59
+	Mm
		989950 PDE4D_MOUSE (50-478): 4.45e-151: 452: 32.07		1433Z_MOUSE (1-245): 3.49e-145: 407: 99.59
+	Hs
		990766 PDE7B_HUMAN (82-436): 1.63e-127: 381: 29.17		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		902310 PDE6C_HUMAN (105-447): 1.63e-121: 379: 23.89		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		972026 PDE7B_HUMAN (82-436): 1.63e-127: 381: 29.17		1433E_HUMAN (2-241): 9.95e-144: 403: 68.18
+	Hs
		990206 PDE7A_HUMAN (104-436): 2.87e-123: 372: 28.99		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		691457 PDE7B_HUMAN (82-436): 1.63e-127: 381: 29.17		1433T_HUMAN (1-245): 2.61e-140: 395: 79.59
+	Hs
		971509 PDE7A_HUMAN (104-436): 2.87e-123: 372: 28.99		1433E_HUMAN (2-241): 9.95e-144: 403: 68.18
+	Hs
		690843 PDE6C_HUMAN (105-447): 1.63e-121: 379: 23.89		1433T_HUMAN (1-245): 2.61e-140: 395: 79.59
+	Hs
		730268 PDE7B_HUMAN (82-436): 1.63e-127: 381: 29.17		1433B_HUMAN (1-242): 9.05e-140: 393: 87.60
+	Hs
		729692 PDE6C_HUMAN (105-447): 1.63e-121: 379: 23.89		1433B_HUMAN (1-242): 9.05e-140: 393: 87.60
+	Hs
		729820 PDE7A_HUMAN (104-436): 2.87e-123: 372: 28.99		1433B_HUMAN (1-242): 9.05e-140: 393: 87.60
+	Hs
		966903 PDE7B_HUMAN (82-436): 1.63e-127: 381: 29.17		1433G_HUMAN (1-240): 2.38e-108: 314: 74.59
+	Hs
		990219 PDE3A_HUMAN (154-427): 1.29e-51: 191: 35.67		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		990185 PDE3B_HUMAN (154-427): 9.02e-51: 189: 35.46		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		971482 PDE3B_HUMAN (154-427): 9.02e-51: 189: 35.46		1433E_HUMAN (2-241): 9.95e-144: 403: 68.18
+	Hs
		691001 PDE3A_HUMAN (154-427): 1.29e-51: 191: 35.67		1433T_HUMAN (1-245): 2.61e-140: 395: 79.59
+	Hs
		690976 PDE3B_HUMAN (154-427): 9.02e-51: 189: 35.46		1433T_HUMAN (1-245): 2.61e-140: 395: 79.59
+	Hs
		966274 PDE3B_HUMAN (154-427): 9.02e-51: 189: 35.46		1433G_HUMAN (1-240): 2.38e-108: 314: 74.59