HitPredict

Interactor 1: VGFR2 (P35968)
Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)
Gene: KDR

Interactor 2: FBW1B (Q9UKB1)
F-box/WD repeat-containing protein 11 (F-box and WD repeats protein beta-TrCP2) (F-box/WD repeat-containing protein 1B) (Homologous to Slimb protein) (HOS)
Gene: FBXW11

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.600

Property	Details
Experiments	21900206, 22711876
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1356 Hs			1 542
+	Hs
		729704 VGFR2_HUMAN (1-1356): 0: 1028: 100.00		FBW1A_HUMAN (26-542): 3.86e-155: 458: 84.59
+	Hs
		557285 PGFRA_HUMAN (11-545): 1.02e-53: 207: 19.71		FBW1B_HUMAN (1-542): 9.69e-174: 503: 100.00
+	Hs
		427014 CSF1R_HUMAN (458-975): 2.36e-14: 80.4: 10.19		FBW1B_HUMAN (1-542): 9.69e-174: 503: 100.00
+	Hs
		729378 VGFR3_HUMAN (1-123): 1.31e-13: 78.1: 14.93		FBW1B_HUMAN (1-542): 9.69e-174: 503: 100.00
+	Hs
		427016 CSF1R_HUMAN (458-975): 2.36e-14: 80.4: 10.19		FBW1A_HUMAN (26-542): 3.86e-155: 458: 84.59
+	Hs
		572595 VGFR1_HUMAN (1-131): 5.1e-20: 99.3: 13.38		LIS1_HUMAN (276-542): 4.94e-75: 245: 28.43
+	Hs
		738171 FLT3_HUMAN (40-555): 7.17e-20: 98.5: 16.22		LIS1_HUMAN (276-542): 4.94e-75: 245: 28.43
+	Hs
		609202 FGFR3_HUMAN (1-120): 8.75e-18: 91.6: 16.90		LIS1_HUMAN (276-542): 4.94e-75: 245: 28.43