HitPredict

Interactor 1: PRS7 (P35998)
26S proteasome regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2)
Gene: PSMC2

Interactor 2: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	33545068, 15340068
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000932 - P-body GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 433 Hs			1 440
+	Hs
		798651 PRS6B_HUMAN (3-425): 2.12e-121: 361: 35.93		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		907015 PRS8_HUMAN (35-430): 2.5e-119: 355: 45.20		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		913258 PRS10_HUMAN (39-429): 1.33e-119: 355: 42.46		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Mm
		907210 PRS8_MOUSE (35-430): 2.5e-119: 355: 45.20		SQSTM_MOUSE (1-440): 0: 731: 90.72
+	Dm
		536010 Q7KMQ0_DROME (1-433): 1.08e-142: 416: 91.69		REF2P_DROME (107-170): 7.35e-20: 94: 36.92
+	Hs
		319742 PRS7_HUMAN (1-433): 3.93e-144: 419: 100.00		HERC2_HUMAN (120-197): 2.6e-12: 71.3: 32.50
+	Hs
		730260 PRS7_HUMAN (1-433): 3.93e-144: 419: 100.00		NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78
+	Dm
		536031 Q9W414_DROME (42-429): 1.84e-116: 347: 44.36		REF2P_DROME (107-170): 7.35e-20: 94: 36.92
+	Hs
		319752 PRS6B_HUMAN (3-425): 2.12e-121: 361: 35.93		HERC2_HUMAN (120-197): 2.6e-12: 71.3: 32.50