HitPredict

Interactor 1: U2AF2 (P36629)
Splicing factor U2AF 59 kDa subunit (U2 auxiliary factor 59 kDa subunit) (U2AF59) (U2 snRNP auxiliary factor large subunit)
Gene: prp2

Interactor 2: U2AF1 (Q09176)
Splicing factor U2AF 23 kDa subunit (U2 auxiliary factor 23 kDa subunit) (U2AF23) (U2 snRNP auxiliary factor small subunit)
Gene: SPAP8A3.06

Species: Schizosaccharomyces pombe 972h-

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.966

Property	Details
Experiments	15548596, 9671485, 12374752, 8657565, 26771498, 26215567, 10923022, 11686295, 23695164
Identification Methods	two hybrid, affinity chromatography technology, pull down, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1, RRM_1~zf-CCCH
Common GO terms	GO:0000243 - commitment complex GO:0005634 - nucleus GO:0030628 - pre-mRNA 3'-splice site binding GO:0045292 - mRNA cis splicing, via spliceosome GO:0071004 - U2-type prespliceosome and 1 others more... GO:0089701 - U2AF complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 517 Sp			1 216
+	Ce
		954186 U2AF2_CAEEL (112-517): 1.04e-110: 339: 26.85		Q9U2U0_CAEEL (2-187): 7.55e-80: 241: 52.33
+	Dm
		1098215 U2AF2_DROME (126-517): 4.1e-79: 255: 29.15		U2AF1_DROME (1-180): 2.15e-85: 255: 58.51
+	At
		188099 U2A2A_ARATH (12-517): 2.53e-76: 252: 22.64		U2AFB_ARATH (1-181): 3.04e-82: 248: 54.84
+	Dm
		1276838 Q9W1T4_DROME (103-516): 7.57e-74: 242: 24.65		U2AF1_DROME (1-180): 2.15e-85: 255: 58.51
+	Hs
		641723 U2AF2_HUMAN (113-517): 6.48e-69: 230: 28.85		U2AF1_HUMAN (1-180): 2.2e-88: 261: 59.68
+	Hs
		516470 PABP1_HUMAN (55-441): 2.15e-54: 195: 10.20		U2AF1_HUMAN (1-180): 2.2e-88: 261: 59.68
+	Hs
		641801 U2AF2_HUMAN (113-517): 6.48e-69: 230: 28.85		U2AFL_HUMAN (12-206): 2.35e-69: 221: 35.07
+	Hs
		963205 RBM39_HUMAN (85-423): 6.36e-20: 94.9: 17.54		U2AF1_HUMAN (1-180): 2.2e-88: 261: 59.68
+	At
		96446 F4ILE1_ARATH (106-514): 2.16e-20: 96.4: 17.76		U2AFA_ARATH (1-206): 2.59e-81: 246: 47.69
+	Hs
		641773 U2AF2_HUMAN (113-517): 6.48e-69: 230: 28.85		RBM39_HUMAN (39-144): 7.38e-28: 111: 23.59
+	At
		1351706 Q9ZVW9_ARATH (106-514): 1.04e-19: 94.1: 17.76		U2AFA_ARATH (1-206): 2.59e-81: 246: 47.69
+	Hs
		1054312 ELAV3_HUMAN (170-514): 4.07e-67: 222: 13.73		RBM39_HUMAN (39-144): 7.38e-28: 111: 23.59
+	Hs
		641894 U2AF2_HUMAN (113-517): 6.48e-69: 230: 28.85		SPF45_HUMAN (43-145): 5.28e-25: 102: 23.81
+	Hs
		1031328 PABP4_HUMAN (55-474): 7.41e-56: 199: 10.39		RBM39_HUMAN (39-144): 7.38e-28: 111: 23.59
+	Hs
		516518 PABP1_HUMAN (55-441): 2.15e-54: 195: 10.20		RBM39_HUMAN (39-144): 7.38e-28: 111: 23.59
+	Hs
		1020258 ELAV2_HUMAN (154-393): 9.23e-39: 146: 11.46		RBM39_HUMAN (39-144): 7.38e-28: 111: 23.59
+	Rn
		1144137 UHMK1_RAT (415-513): 2.78e-34: 135: 32.32		UHMK1_RAT (43-151): 1.83e-26: 106: 19.27
+	Dm
		1370583 Q9VM49_DROME (177-512): 3.7e-28: 120: 17.85		Q9VM49_DROME (43-144): 4.35e-25: 103: 21.57
+	Hs
		1054309 RBM39_HUMAN (85-423): 6.36e-20: 94.9: 17.54		RBM39_HUMAN (39-144): 7.38e-28: 111: 23.59
+	Hs
		1054407 RBM23_HUMAN (89-387): 8.95e-17: 84.5: 17.22		RBM39_HUMAN (39-144): 7.38e-28: 111: 23.59