Protein: SIZ1
E3 SUMO-protein ligase SIZ1 (EC 2.3.2.-) (E3 SUMO-protein transferase SIZ2) (SAP and Miz-finger domain-containing protein 1) (Ubiquitin-like protein ligase 1)

Gene: SIZ1
Organism: Saccharomyces cerevisiae S288C
Interactions: 107
UniProt ID: Q04195

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0003690 - double-stranded DNA binding
GO:0005634 - nucleus
GO:0005935 - cellular bud neck
GO:0005940 - septin ring

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

897501

UBC9
SUMO-conjugating enzyme UBC9

12

14

Small-scale

0.981

High

1045176

SMT3
Ubiquitin-like protein SMT3

6

20

Small-scale

0.937

High

586487

PCNA
Proliferating cell nuclear antigen

5

3

Small-scale

0.926

High

737038

CDC3
Cell division control protein 3

3

1

Small-scale

0.653

High

557765

SRS2
ATP-dependent DNA helicase SRS2

2

3

Small-scale

0.614

High

737115

CDC11
Cell division control protein 11

2

3

Small-scale

0.601

High

449003

TOP2
DNA topoisomerase 2

2

4

Small-scale

0.595

High

745498

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

1

1

Small-scale

0.586

High

815562

RSP5
E3 ubiquitin-protein ligase RSP5

1

3

Small-scale

0.561

High

818139

SHO1
High osmolarity signaling protein SHO1

1

1

Small-scale

0.552

High

916899

IMB5
Importin subunit beta-5

1

3

Small-scale

0.552

High

818095

SLX8
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8

1

1

Small-scale

0.536

High

448404

RAD1
DNA repair protein RAD1

1

2

Small-scale

0.501

High

448473

RAD52
DNA repair and recombination protein RAD52

1

1

Small-scale

0.501

High

779343

CENPA
Histone H3-like centromeric protein CSE4

1

11

Small-scale

0.501

High

814146

SAW1
Single-strand annealing weakened protein 1

1

1

Small-scale

0.501

High

814742

EXO1
Exodeoxyribonuclease 1

1

2

Small-scale

0.501

High

917751

XRCC4
Non-homologous end-joining factor LIF1

1

1

Small-scale

0.501

High

1045174

SGO1
Shugoshin

1

1

High-throughput

0.501

High

919146

YG36
Uncharacterized protein YGR126W

1

0

High-throughput

0.493

High

1045171

PRP11
Pre-mRNA-splicing factor PRP11

1

0

High-throughput

0.486

High

1043841

NSE5
Non-structural maintenance of chromosome element 5

1

1

Small-scale

0.481

High

1045164

EUC1
Transcription factor-like protein EUC1

1

1

Small-scale

0.481

High

150119

YH11B
Transposon Ty1-H Gag-Pol polyprotein

1

1

High-throughput

0.479

High

415244

TOP1
DNA topoisomerase 1

1

3

High-throughput

0.479

High

554731

YPK1
Serine/threonine-protein kinase YPK1

1

4

High-throughput

0.479

High

577580

CYC8
General transcriptional corepressor CYC8

1

4

High-throughput

0.479

High

594553

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.479

High

598436

TUP1
General transcriptional corepressor TUP1

1

2

High-throughput

0.479

High

614846

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

1

4

High-throughput

0.479

High

632824

DBP5
ATP-dependent RNA helicase DBP5

1

4

High-throughput

0.479

High

660879

PP2A2
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

1

7

High-throughput

0.479

High

670334

NAP1
Nucleosome assembly protein

1

1

High-throughput

0.479

High

672266

CDC10
Cell division control protein 10

1

2

High-throughput

0.479

High

679002

NOT1
General negative regulator of transcription subunit 1

1

1

High-throughput

0.479

High

708096

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

734471

BTAF1
TATA-binding protein-associated factor MOT1

1

7

High-throughput

0.479

High

737651

HIR1
Protein HIR1

1

2

High-throughput

0.479

High

739760

SPT16
FACT complex subunit SPT16

1

2

High-throughput

0.479

High

743053

SWI3
SWI/SNF complex subunit SWI3

1

5

High-throughput

0.479

High

745423

FZF1
Zinc finger protein FZF1

1

3

High-throughput

0.479

High

792669

AP2A
AP-2 complex subunit alpha

1

4

High-throughput

0.479

High

800972

RFC3
Replication factor C subunit 3

1

2

High-throughput

0.479

High

801019

RFC1
Replication factor C subunit 1

1

4

High-throughput

0.479

High

807012

SPP41
Protein SPP41

1

7

High-throughput

0.479

High

822972

RFC4
Replication factor C subunit 4

1

4

High-throughput

0.479

High

823097

VPS27
Vacuolar protein sorting-associated protein 27

1

2

High-throughput

0.479

High

850194

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

1

High-throughput

0.479

High

850570

RSC8
Chromatin structure-remodeling complex protein RSC8

1

2

High-throughput

0.479

High

915397

MSN5
Protein MSN5

1

2

High-throughput

0.479

High

917060

MCM6
DNA replication licensing factor MCM6

1

2

High-throughput

0.479

High

917320

INO80
Chromatin-remodeling ATPase INO80

1

6

High-throughput

0.479

High

919688

RT102
Regulator of Ty1 transposition protein 102

1

1

High-throughput

0.479

High

922629

HST1
NAD-dependent protein deacetylase HST1

1

2

High-throughput

0.479

High

1010207

ARP4
Actin-related protein 4

1

5

High-throughput

0.479

High

1045087

SXM1
Importin beta SMX1

1

3

High-throughput

0.479

High

1045165

CYK2
Cytokinesis protein 2

1

4

High-throughput

0.479

High

1045166

ARP9
Actin-like protein ARP9

1

3

High-throughput

0.479

High

1045168

HRQ1
ATP-dependent helicase HRQ1

1

4

High-throughput

0.479

High

1045170

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

9

High-throughput

0.479

High

1045172

SHS1
Seventh homolog of septin 1

1

5

High-throughput

0.479

High

1045175

MRN1
RNA-binding protein MRN1

1

1

High-throughput

0.479

High

1045177

ARP8
Actin-like protein ARP8

1

5

High-throughput

0.479

High

1045178

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.479

High

864746

BBC1
Myosin tail region-interacting protein MTI1

1

5

High-throughput

0.464

High

150309

RPN13
26S proteasome regulatory subunit RPN13

1

0

High-throughput

0.458

High

483805

SWI1
SWI/SNF chromatin-remodeling complex subunit SWI1

1

0

High-throughput

0.458

High

506246

HAP1
Heme-responsive zinc finger transcription factor HAP1

1

0

High-throughput

0.458

High

553561

PDR1
Transcription factor PDR1

1

0

High-throughput

0.458

High

636943

FAR1
Cyclin-dependent kinase inhibitor FAR1

1

0

High-throughput

0.458

High

642073

DPOE
DNA polymerase epsilon catalytic subunit A

1

0

High-throughput

0.458

High

665203

DPB2
DNA polymerase epsilon subunit B

1

0

High-throughput

0.458

High

676824

BUD3
Bud site selection protein 3

1

0

High-throughput

0.458

High

737340

CDC12
Cell division control protein 12

1

0

High-throughput

0.458

High

738918

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

0

High-throughput

0.458

High

805576

SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific

1

0

High-throughput

0.458

High

808738

ITS3
Phosphatidylinositol 4-phosphate 5-kinase MSS4

1

0

High-throughput

0.458

High

824976

CSM2
Chromosome segregation in meiosis protein 2

1

0

High-throughput

0.458

High

836644

GPD2
Glycerol-3-phosphate dehydrogenase [NAD(+)] 2, mitochondrial

1

0

High-throughput

0.458

High

849893

IES1
Ino eighty subunit 1

1

0

High-throughput

0.458

High

858419

SUM1
Suppressor of mar1-1 protein

1

0

High-throughput

0.458

High

1040995

RSC9
Chromatin structure-remodeling complex subunit RSC9

1

0

High-throughput

0.458

High

1045167

RT103
Regulator of Ty1 transposition protein 103

1

0

High-throughput

0.458

High

1045169

FKBP4
FK506-binding protein 4

1

0

High-throughput

0.458

High

527605

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

546168

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

High-throughput

0.445

High

676322

MAS5
Mitochondrial protein import protein MAS5

1

2

High-throughput

0.445

High

804431

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

High-throughput

0.445

High

738509

NUP2
Nucleoporin NUP2

1

4

Small-scale

0.439

High

368193

THDH
Threonine dehydratase, mitochondrial

1

3

High-throughput

0.437

High

454238

LEUC
3-isopropylmalate dehydratase

1

1

High-throughput

0.437

High

668440

PTP1
Tyrosine-protein phosphatase 1

1

1

High-throughput

0.437

High

780479

NNRD
ATP-dependent

1

1

High-throughput

0.437

High

799693

TSL1
Trehalose synthase complex regulatory subunit TSL1

1

1

High-throughput

0.437

High

815331

IF4F2
Eukaryotic initiation factor 4F subunit p130

1

6

High-throughput

0.437

High

824787

MLP2
Protein MLP2

1

6

High-throughput

0.437

High

850748

COPD
Coatomer subunit delta

1

1

High-throughput

0.437

High

865641

GPN1
GPN-loop GTPase 1

1

1

High-throughput

0.437

High

1038593

PDR12
ATP-dependent permease PDR12

1

1

High-throughput

0.437

High

739459

ZUO1
Zuotin

1

2

High-throughput

0.407

High

1045173

FRA1
Putative Xaa-Pro aminopeptidase FRA1

2

0

High-throughput

0.313

High

438825

CYSD
Homocysteine/cysteine synthase

1

0

High-throughput

0.269

Low

657199

GYS1
Glycogen [starch] synthase isoform 1

1

0

High-throughput

0.249

Low

736592

RIM1
Single-stranded DNA-binding protein RIM1, mitochondrial

1

0

High-throughput

0.249

Low

789815

SOL2
6-phosphogluconolactonase-like protein 2

1

0

High-throughput

0.249

Low

800646

YGP1
Protein YGP1

1

0

High-throughput

0.249

Low

817089

RPN3
26S proteasome regulatory subunit RPN3

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025