HitPredict

Interactor 1: TGFR1 (P36897)
TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
Gene: TGFBR1

Interactor 2: ACVL1 (P37023)
Serine/threonine-protein kinase receptor R3 (SKR3) (EC 2.7.11.30) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I)
Gene: ACVRL1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.60 1.00 0.776

The method score is based on:

Property Details
Experiments 8242742, 18333754
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, cross-linking study
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~Pkinase, Pkinase~TGF_beta_GS, PK_Tyr_Ser-Thr~TGF_beta_GS
Common GO terms GO:0001701 - in utero embryonic development
GO:0001937 - negative regulation of endothelial cell proliferation
GO:0001938 - positive regulation of endothelial cell proliferation
GO:0004674 - protein serine/threonine kinase activity
GO:0004675 - transmembrane receptor protein serine/threonine kinase activity
and 19 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 503
Hs

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Last updated: 15 Jul 2024