Protein: NUP98
Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)]

Gene: NUP98
Organism: Homo sapiens
Interactions: 209
UniProt ID: P52948

Gene Ontology (top 5):
GO:0000973 - post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
GO:0003713 - transcription coactivator activity
GO:0003723 - RNA binding
GO:0003729 - mRNA binding
GO:0005635 - nuclear envelope

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

915943

RAE1L
mRNA export factor RAE1

17

20

Small-scale

0.989

High

916001

NUP43
Nucleoporin Nup43

8

9

High-throughput

0.966

High

915935

NU107
Nuclear pore complex protein Nup107

7

12

Small-scale

0.958

High

916026

NUP88
Nuclear pore complex protein Nup88

5

3

Small-scale

0.931

High

915933

SEC13
Protein SEC13 homolog

5

20

High-throughput

0.927

High

915931

NUP98
Nuclear pore complex protein Nup98-Nup96

2

20

Small-scale

0.768

High

916055

NXF1
Nuclear RNA export factor 1

8

14

Small-scale

0.750

High

915960

IMB1
Importin subunit beta-1

7

20

Small-scale

0.743

High

916006

NU133
Nuclear pore complex protein Nup133

6

11

Small-scale

0.732

High

385586

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

5

15

High-throughput

0.702

High

916002

NUP37
Nucleoporin Nup37

1

6

High-throughput

0.691

High

916022

SEH1
Nucleoporin SEH1

1

20

High-throughput

0.691

High

916034

NUP85
Nuclear pore complex protein Nup85

4

11

Small-scale

0.686

High

915949

NU160
Nuclear pore complex protein Nup160

4

4

High-throughput

0.676

High

916054

SPAST
Spastin

3

8

High-throughput

0.662

High

775507

NU214
Nuclear pore complex protein Nup214

3

19

Small-scale

0.656

High

291270

NU155
Nuclear pore complex protein Nup155

3

20

Small-scale

0.651

High

915973

NU188
Nucleoporin NUP188

1

2

Small-scale

0.647

High

916011

CBP
CREB-binding protein

2

6

Small-scale

0.629

High

915968

CDC37
Hsp90 co-chaperone Cdc37

2

1

High-throughput

0.628

High

285156

EED
Polycomb protein EED

1

9

High-throughput

0.618

High

915934

WDR4
tRNA

1

7

High-throughput

0.618

High

172603

XPO1
Exportin-1

2

20

Small-scale

0.611

High

890285

NU153
Nuclear pore complex protein Nup153

2

17

Small-scale

0.611

High

915961

NUMA1
Nuclear mitotic apparatus protein 1

2

3

Small-scale

0.611

High

911519

NCBP2
Nuclear cap-binding protein subunit 2

2

2

High-throughput

0.601

High

552777

TPR
Nucleoprotein TPR

2

20

Small-scale

0.595

High

916008

NU205
Nuclear pore complex protein Nup205

2

14

Small-scale

0.595

High

241169

PRKN
E3 ubiquitin-protein ligase parkin

2

6

High-throughput

0.584

High

910821

IMA1
Importin subunit alpha-1

2

20

Small-scale

0.584

High

915936

SC61B
Protein transport protein Sec61 subunit beta

2

2

High-throughput

0.584

High

915946

TF65
Transcription factor p65

2

6

Small-scale

0.584

High

916003

NUP35
Nucleoporin NUP35

2

3

High-throughput

0.584

High

916066

FAF1
FAS-associated factor 1

2

1

High-throughput

0.584

High

915974

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.575

High

74010

MYO9A
Unconventional myosin-IXa

2

5

High-throughput

0.571

High

789081

NUP62
Nuclear pore glycoprotein p62

2

19

Small-scale

0.571

High

915959

RRP1B
Ribosomal RNA processing protein 1 homolog B

2

2

High-throughput

0.571

High

915994

ARHGJ
Rho guanine nucleotide exchange factor 19

2

5

High-throughput

0.571

High

915956

HDAC1
Histone deacetylase 1

1

3

Small-scale

0.561

High

915993

CMTD1
Catechol O-methyltransferase domain-containing protein 1

2

1

High-throughput

0.558

High

915942

CSK21
Casein kinase II subunit alpha

1

4

High-throughput

0.550

High

668538

APC
Adenomatous polyposis coli protein

1

6

High-throughput

0.541

High

515782

RGPD1
RANBP2-like and GRIP domain-containing protein 1

1

20

High-throughput

0.536

High

720973

CLIP1
CAP-Gly domain-containing linker protein 1

1

4

High-throughput

0.536

High

849309

RANG
Ran-specific GTPase-activating protein

1

20

High-throughput

0.536

High

853633

MK08
Mitogen-activated protein kinase 8

1

5

High-throughput

0.536

High

908901

NEK4
Serine/threonine-protein kinase Nek4

1

6

High-throughput

0.536

High

915932

LIMK1
LIM domain kinase 1

1

6

High-throughput

0.536

High

915939

RAN
GTP-binding nuclear protein Ran

1

5

High-throughput

0.536

High

915941

UBC9
SUMO-conjugating enzyme UBC9

1

3

High-throughput

0.536

High

915958

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

6

High-throughput

0.536

High

915966

MARE1
Microtubule-associated protein RP/EB family member 1

1

3

High-throughput

0.536

High

916013

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

9

High-throughput

0.536

High

916033

NUP58
Nucleoporin p58/p45

1

20

High-throughput

0.536

High

916035

HDAC8
Histone deacetylase 8

1

4

High-throughput

0.536

High

916040

CHM4B
Charged multivesicular body protein 4b

1

3

High-throughput

0.536

High

916049

DISC1
Disrupted in schizophrenia 1 protein

1

3

High-throughput

0.536

High

916069

RPKL1
Ribosomal protein S6 kinase-like 1

1

5

High-throughput

0.536

High

916068

CLC11
C-type lectin domain family 11 member A

2

2

High-throughput

0.521

High

915970

H31T
Histone H3.1t

1

7

High-throughput

0.515

High

916014

H2B1H
Histone H2B type 1-H

1

9

High-throughput

0.515

High

916031

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

4

Small-scale

0.515

High

916038

QRIC2
Glutamine-rich protein 2

1

17

High-throughput

0.515

High

916043

MOB1A
MOB kinase activator 1A

1

1

High-throughput

0.515

High

228214

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.513

High

486550

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.513

High

915984

TF2H5
General transcription factor IIH subunit 5

1

0

High-throughput

0.513

High

916062

CAPS1
Calcium-dependent secretion activator 1

1

0

High-throughput

0.513

High

915940

DYLT1
Dynein light chain Tctex-type 1

1

2

Small-scale

0.512

High

164551

TNPO2
Transportin-2

1

20

Small-scale

0.501

High

916012

TNPO1
Transportin-1

1

20

Small-scale

0.501

High

683221

TNR5
Tumor necrosis factor receptor superfamily member 5

1

3

High-throughput

0.489

High

915951

FOXL1
Forkhead box protein L1

1

4

High-throughput

0.489

High

915982

FOXI2
Forkhead box protein I2

1

4

High-throughput

0.489

High

916021

HDA11
Histone deacetylase 11

1

7

High-throughput

0.489

High

916037

FOXQ1
Forkhead box protein Q1

1

5

High-throughput

0.489

High

916053

PIM2
Serine/threonine-protein kinase pim-2

1

2

High-throughput

0.489

High

128882

MEN1
Menin

1

1

High-throughput

0.479

High

157127

CTRO
Citron Rho-interacting kinase

1

6

High-throughput

0.479

High

190127

TNC18
Trinucleotide repeat-containing gene 18 protein

1

1

High-throughput

0.479

High

222848

PRC1
Protein regulator of cytokinesis 1

1

2

High-throughput

0.479

High

227444

SPOP
Speckle-type POZ protein

1

6

High-throughput

0.479

High

247267

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

3

High-throughput

0.479

High

247757

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

259669

BRD4
Bromodomain-containing protein 4

1

10

High-throughput

0.479

High

272006

OBSL1
Obscurin-like protein 1

1

3

High-throughput

0.479

High

330780

KI20A
Kinesin-like protein KIF20A

1

6

High-throughput

0.479

High

515817

RGPD2
RANBP2-like and GRIP domain-containing protein 2

1

20

Small-scale

0.479

High

588274

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

606482

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.479

High

611046

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

2

High-throughput

0.479

High

634374

LMNB1
Lamin-B1

1

15

High-throughput

0.479

High

695001

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

718524

CDC27
Cell division cycle protein 27 homolog

1

2

Small-scale

0.479

High

731114

STIP1
Stress-induced-phosphoprotein 1

1

5

High-throughput

0.479

High

764566

CTNB1
Catenin beta-1

1

20

High-throughput

0.479

High

767765

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

832962

ETV6
Transcription factor ETV6

1

5

High-throughput

0.479

High

842626

WASP
Actin nucleation-promoting factor WAS

1

4

Small-scale

0.479

High

851729

NKX21
Homeobox protein Nkx-2.1

1

10

High-throughput

0.479

High

878819

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

5

High-throughput

0.479

High

894644

EMD
Emerin

1

2

High-throughput

0.479

High

897669

CDK9
Cyclin-dependent kinase 9

1

4

High-throughput

0.479

High

911192

IMA5
Importin subunit alpha-5

1

20

Small-scale

0.479

High

915937

WDR5
WD repeat-containing protein 5

1

3

High-throughput

0.479

High

915938

H4
Histone H4

1

3

High-throughput

0.479

High

915947

CKAP4
Cytoskeleton-associated protein 4

1

8

High-throughput

0.479

High

915948

EP300
Histone acetyltransferase p300

1

6

Small-scale

0.479

High

915950

CDC20
Cell division cycle protein 20 homolog

1

6

Small-scale

0.479

High

915952

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

1

Small-scale

0.479

High

915953

G3BP1
Ras GTPase-activating protein-binding protein 1

1

8

High-throughput

0.479

High

915954

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

915955

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

6

Small-scale

0.479

High

915962

CUL7
Cullin-7

1

4

High-throughput

0.479

High

915964

KIF14
Kinesin-like protein KIF14

1

3

High-throughput

0.479

High

915967

EZH2
Histone-lysine N-methyltransferase EZH2

1

4

High-throughput

0.479

High

915969

IF16
Gamma-interferon-inducible protein 16

1

3

High-throughput

0.479

High

915971

GLE1
mRNA export factor GLE1

1

11

High-throughput

0.479

High

915975

RNF43
E3 ubiquitin-protein ligase RNF43

1

4

High-throughput

0.479

High

915981

SYNE3
Nesprin-3

1

2

High-throughput

0.479

High

915986

NUP54
Nucleoporin p54

1

19

High-throughput

0.479

High

915988

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

8

High-throughput

0.479

High

915989

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

3

High-throughput

0.479

High

915990

SLN11
Schlafen family member 11

1

2

High-throughput

0.479

High

915991

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

2

High-throughput

0.479

High

915992

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

915995

SMC5
Structural maintenance of chromosomes protein 5

1

6

High-throughput

0.479

High

915997

SIR6
NAD-dependent protein deacylase sirtuin-6

1

7

High-throughput

0.479

High

916004

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.479

High

916007

LMO7
LIM domain only protein 7

1

1

High-throughput

0.479

High

916010

ESR2
Estrogen receptor beta

1

11

High-throughput

0.479

High

916015

FBX32
F-box only protein 32

1

1

High-throughput

0.479

High

916024

RUFY1
RUN and FYVE domain-containing protein 1

1

1

High-throughput

0.479

High

916027

TBX5
T-box transcription factor TBX5

1

2

High-throughput

0.479

High

916029

B9D2
B9 domain-containing protein 2

1

1

High-throughput

0.479

High

916044

ECT2
Protein ECT2

1

6

High-throughput

0.479

High

916045

ANLN
Anillin

1

2

High-throughput

0.479

High

916046

PAR11
Protein mono-ADP-ribosyltransferase PARP11

1

5

High-throughput

0.479

High

916047

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

7

High-throughput

0.479

High

916048

FBX6
F-box only protein 6

1

3

High-throughput

0.479

High

916052

CXXC1
CXXC-type zinc finger protein 1

1

4

High-throughput

0.479

High

916056

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.479

High

916057

TBK1
Serine/threonine-protein kinase TBK1

1

3

High-throughput

0.479

High

916061

NUP50
Nuclear pore complex protein Nup50

1

20

High-throughput

0.479

High

916063

FZR1
Fizzy-related protein homolog

1

6

Small-scale

0.479

High

916064

APC10
Anaphase-promoting complex subunit 10

1

4

Small-scale

0.479

High

916009

TTC9A
Tetratricopeptide repeat protein 9A

1

3

High-throughput

0.470

High

125342

LEG9
Galectin-9

1

0

High-throughput

0.458

High

165138

CPLX1
Complexin-1

1

0

High-throughput

0.458

High

353801

PTTG1
Securin

1

0

Small-scale

0.458

High

446797

NPM
Nucleophosmin

1

0

Small-scale

0.458

High

550938

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

837479

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

915944

CYC
Cytochrome c

1

0

High-throughput

0.458

High

915976

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

915999

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.458

High

916017

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

916020

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

916023

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

916028

CTIP
DNA endonuclease RBBP8

1

0

High-throughput

0.458

High

916030

CHOLN
Protein cholesin

1

0

High-throughput

0.458

High

916042

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

916050

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.458

High

916059

APC4
Anaphase-promoting complex subunit 4

1

0

Small-scale

0.458

High

143416

E2F3
Transcription factor E2F3

1

1

Small-scale

0.445

High

171421

S27A2
Long-chain fatty acid transport protein 2

1

1

High-throughput

0.445

High

371540

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.445

High

664853

RAE1
Rab proteins geranylgeranyltransferase component A 1

1

1

High-throughput

0.445

High

915972

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

916067

DICER
Endoribonuclease Dicer

1

4

Small-scale

0.445

High

916060

TNIK
TRAF2 and NCK-interacting protein kinase

1

0

High-throughput

0.438

High

58753

TTC24
Tetratricopeptide repeat protein 24

1

1

High-throughput

0.437

High

136856

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

5

High-throughput

0.437

High

335724

RPGF3
Rap guanine nucleotide exchange factor 3

1

1

Small-scale

0.437

High

376768

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

9

High-throughput

0.437

High

915963

HAPR1
HUWE1-associated protein modifying stress responses 1

1

2

Small-scale

0.437

High

915965

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

2

High-throughput

0.437

High

915979

LMBRL
Protein LMBR1L

1

3

High-throughput

0.437

High

915980

DPPA3
Developmental pluripotency-associated protein 3

1

1

High-throughput

0.437

High

915983

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

915985

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

1

Small-scale

0.437

High

915987

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.437

High

916005

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

3

High-throughput

0.437

High

916016

RN166
E3 ubiquitin-protein ligase RNF166

1

6

High-throughput

0.437

High

916036

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.437

High

916039

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

1

High-throughput

0.437

High

916041

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

916058

DS13B
Dual specificity protein phosphatase 13B

1

1

High-throughput

0.437

High

916065

ALK
ALK tyrosine kinase receptor

1

7

High-throughput

0.437

High

322590

FBX21
F-box only protein 21

1

0

Small-scale

0.426

High

915978

S27A1
Long-chain fatty acid transport protein 1

1

1

High-throughput

0.407

High

915998

S35G3
Solute carrier family 35 member G3

1

1

High-throughput

0.407

High

749185

CD70
CD70 antigen

2

0

High-throughput

0.328

High

916000

UXS1
UDP-glucuronic acid decarboxylase 1

2

0

High-throughput

0.328

High

916019

F136A
Protein FAM136A

2

0

High-throughput

0.328

High

915996

PNKD
Probable thioesterase PNKD

2

0

High-throughput

0.318

High

253826

TPST2
Protein-tyrosine sulfotransferase 2

1

0

High-throughput

0.279

Low

915977

VASN
Vasorin

1

0

High-throughput

0.279

Low

916051

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.279

Low

847483

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.249

Low

915945

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.249

Low

915957

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.249

Low

916018

ARL8A
ADP-ribosylation factor-like protein 8A

1

0

High-throughput

0.249

Low

916025

SEC62
Translocation protein SEC62

1

0

High-throughput

0.249

Low

916032

DERL1
Derlin-1

1

0

High-throughput

0.249

Low

552175

ADT3
ADP/ATP translocase 3

1

0

High-throughput

0.232

Low

653209

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025