HitPredict

Interactor 1: TNR3 (P36941)
Tumor necrosis factor receptor superfamily member 3 (Lymphotoxin-beta receptor) (Tumor necrosis factor C receptor) (Tumor necrosis factor receptor 2-related protein) (Tumor necrosis factor receptor type III) (TNF-RIII) (TNFR-III)
Gene: LTBR

Interactor 2: RN166 (Q96A37)
E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING finger protein 166) (RING-type E3 ubiquitin transferase RNF166)
Gene: RNF166

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.50	0.609

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 435 Hs			1 237
+	Hs
		738713 TNR3_HUMAN (1-435): 8.16e-134: 393: 100.00		RN114_HUMAN (18-236): 1.44e-49: 163: 46.12
+	Hs
		738661 TNR3_HUMAN (1-435): 8.16e-134: 393: 100.00		TRAF3_HUMAN (15-215): 4.28e-31: 121: 20.29
+	Hs
		129536 TNR3_HUMAN (1-435): 8.16e-134: 393: 100.00		TRAF5_HUMAN (12-237): 8.71e-31: 120: 21.21
+	Hs
		738694 TNR3_HUMAN (1-435): 8.16e-134: 393: 100.00		TRAF4_HUMAN (17-212): 3.54e-28: 112: 18.50
+	Hs
		738696 TNR3_HUMAN (1-435): 8.16e-134: 393: 100.00		TRIM4_HUMAN (22-162): 4.4e-28: 112: 19.58
+	Hs
		738659 TNR3_HUMAN (1-435): 8.16e-134: 393: 100.00		TRAF2_HUMAN (15-186): 9.47e-27: 109: 20.65
+	Mm
		838553 TNR3_MOUSE (1-419): 2.77e-106: 322: 68.17		TRAF3_MOUSE (15-215): 1.66e-32: 125: 20.29
+	Mm
		838552 TNR3_MOUSE (1-419): 2.77e-106: 322: 68.17		TRAF5_MOUSE (12-215): 3.61e-30: 119: 20.10
+	Mm
		761805 TNR3_MOUSE (1-419): 2.77e-106: 322: 68.17		TRAF2_MOUSE (15-186): 2.58e-25: 104: 20.11
+	Hs
		584437 TNR1A_HUMAN (36-338): 1.98e-54: 189: 21.43		RN138_HUMAN (21-237): 4.61e-45: 152: 30.83
+	Hs
		584394 TNR1A_HUMAN (36-338): 1.98e-54: 189: 21.43		TRAF3_HUMAN (15-215): 4.28e-31: 121: 20.29
+	Mm
		192587 TNR11_MOUSE (4-254): 6.04e-51: 183: 28.74		TRAF3_MOUSE (15-215): 1.66e-32: 125: 20.29
+	Hs
		584509 TNR1A_HUMAN (36-338): 1.98e-54: 189: 21.43		TRAF6_HUMAN (8-235): 8.66e-29: 114: 17.83
+	Mm
		192584 TNR11_MOUSE (4-254): 6.04e-51: 183: 28.74		TRAF5_MOUSE (12-215): 3.61e-30: 119: 20.10
+	Mm
		192585 TNR11_MOUSE (4-254): 6.04e-51: 183: 28.74		TRAF6_MOUSE (8-235): 1.28e-29: 117: 16.52
+	Hs
		584390 TNR1A_HUMAN (36-338): 1.98e-54: 189: 21.43		TRAF2_HUMAN (15-186): 9.47e-27: 109: 20.65
+	Hs
		129532 TNR5_HUMAN (15-287): 7.61e-52: 177: 26.01		TRAF5_HUMAN (12-237): 8.71e-31: 120: 21.21
+	Mm
		626852 TNR1A_MOUSE (36-339): 2.63e-54: 188: 22.83		TRAF2_MOUSE (15-186): 2.58e-25: 104: 20.11
+	Mm
		192583 TNR11_MOUSE (4-254): 6.04e-51: 183: 28.74		TRAF2_MOUSE (15-186): 2.58e-25: 104: 20.11
+	Hs
		639576 TNR5_HUMAN (15-287): 7.61e-52: 177: 26.01		TRAF2_HUMAN (15-186): 9.47e-27: 109: 20.65