HitPredict

Interactor 1: SRBP1 (P36956)
Sterol regulatory element-binding protein 1 (SREBP-1) (Class D basic helix-loop-helix protein 1) (bHLHd1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1 (Transcription factor SREBF1)]
Gene: SREBF1

Interactor 2: ATX1 (P54253)
Ataxin-1 (Spinocerebellar ataxia type 1 protein)
Gene: ATXN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.620

Property	Details
Experiments	16713569, 32814053
Identification Methods	two hybrid, validated two hybrid, two hybrid array, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm and 1 others more... GO:0005829 - cytosol
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1147 Hs			1 815
+	Hs
		868456 SRBP2_HUMAN (6-1147): 0: 962: 43.61		ATX1_HUMAN (1-815): 0: 1349: 100.00
+	Hs
		868656 CBP_HUMAN (18-407): 2.51e-10: 67.3: 12.37		ATX1_HUMAN (1-815): 0: 1349: 100.00
+	Mm
		869020 IF4G1_MOUSE (3-518): 8.15e-11: 68.8: 10.71		ATX1_MOUSE (1-815): 0: 1271: 86.89
+	Mm
		101431 F8VPR5_MOUSE (11-390): 2.67e-10: 67.3: 10.36		ATX1_MOUSE (1-815): 0: 1271: 86.89
+	Hs
		473481 SRBP1_HUMAN (1-1147): 0: 910: 100.00		ATX1L_HUMAN (1-815): 3.55e-108: 348: 27.15