HitPredict

Interactor 1: SYUA (P37840)
Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP)
Gene: SNCA

Interactor 2: SIAH1 (Q8IUQ4)
E3 ubiquitin-protein ligase SIAH1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH1) (Seven in absentia homolog 1) (Siah-1) (Siah-1a)
Gene: SIAH1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.85 0.60 0.714

The method score is based on:

Property Details
Experiments 27334109, 19224863, 18065497, 18070888
Identification Methods affinity chromatography technology, pull down, enzymatic study
Interaction Type physical association, direct interaction, ubiquitination reaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0008270 - zinc ion binding
GO:0043065 - positive regulation of apoptotic process
and 2 others

more...
Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 140
Hs

1 282
+ Rn
+ Rn
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024