HitPredict

Interactor 1: BRR2 (P32639)
Pre-mRNA-splicing helicase BRR2 (EC 3.6.4.13) (Protein Snu246)
Gene: BRR2

Interactor 2: SMD2 (Q06217)
Small nuclear ribonucleoprotein Sm D2 (Sm-D2) (snRNP core protein D2)
Gene: SMD2

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.720

Property	Details
Experiments	25670679, 11720284, 10449419, 10377396, 16554755, 37968396
Identification Methods	affinity chromatography technology, biochemical, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0000974 - Prp19 complex GO:0005634 - nucleus GO:0005681 - spliceosomal complex GO:0005682 - U5 snRNP and 1 others more... GO:0046540 - U4/U6 x U5 tri-snRNP complex
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 2163 Sc			1 110
+	Hs
		289491 U520_HUMAN (16-2163): 0: 1598: 38.93		SMD2_HUMAN (5-109): 2.22e-47: 149: 52.68
+	Sp
		152649 BRR2_SCHPO (5-2162): 0: 1396: 40.91		SMD2_SCHPO (3-108): 2.55e-53: 164: 53.57
+	Dm
		1477048 Q9Y134_DROME (360-976): 1.74e-96: 340: 20.09		SMD2_DROME (5-109): 3.66e-47: 148: 51.79
+	Sp
		151422 YE02_SCHPO (377-925): 4.57e-87: 311: 21.59		SMD2_SCHPO (3-108): 2.55e-53: 164: 53.57
+	Hs
		974653 DDX23_HUMAN (1275-1768): 5.4e-82: 291: 13.30		SMD2_HUMAN (5-109): 2.22e-47: 149: 52.68
+	Hs
		974550 DHX8_HUMAN (1353-1741): 3.69e-48: 191: 11.03		SMD2_HUMAN (5-109): 2.22e-47: 149: 52.68
+	Sc
		664623 PRP22_YEAST (1343-1825): 9.17e-45: 180: 11.13		SMD2_YEAST (1-110): 1.12e-48: 152: 100.00