Protein: SMD2
Small nuclear ribonucleoprotein Sm D2 (Sm-D2) (snRNP core protein D2)

Gene: SMD2
Organism: Saccharomyces cerevisiae S288C
Interactions: 100
UniProt ID: Q06217

Gene Ontology (top 5):
GO:0000243 - commitment complex
GO:0000245 - spliceosomal complex assembly
GO:0000387 - spliceosomal snRNP assembly
GO:0000395 - mRNA 5'-splice site recognition
GO:0000398 - mRNA splicing, via spliceosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

933143

RUXF
Small nuclear ribonucleoprotein F

6

6

High-throughput

0.947

High

1054391

RU2A
U2 small nuclear ribonucleoprotein A'

6

3

Small-scale

0.941

High

795926

LSM2
LSM complex subunit LSM2

5

11

Small-scale

0.922

High

817165

RSMB
Small nuclear ribonucleoprotein-associated protein B

4

4

High-throughput

0.892

High

820842

RUXG
Small nuclear ribonucleoprotein G

4

11

High-throughput

0.881

High

1054396

RUXE
Small nuclear ribonucleoprotein E

4

2

High-throughput

0.881

High

924557

LSM7
LSM complex subunit LSM7

3

12

High-throughput

0.861

High

818056

LSM4
LSM complex subunit LSM4

3

5

High-throughput

0.858

High

780225

SN114
Pre-mRNA-splicing factor SNU114

3

2

High-throughput

0.855

High

1052782

RU1C
U1 small nuclear ribonucleoprotein C

4

0

High-throughput

0.850

High

751791

PRP8
Pre-mRNA-splicing factor 8

3

1

Small-scale

0.839

High

847834

SMD3
Small nuclear ribonucleoprotein Sm D3

3

13

Small-scale

0.839

High

1027994

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

3

4

High-throughput

0.839

High

1036179

SMD1
Small nuclear ribonucleoprotein Sm D1

3

2

High-throughput

0.839

High

865283

LSM8
LSM2-LSM8 complex subunit LSM8

3

12

High-throughput

0.830

High

1054388

LUC7
Protein LUC7

3

0

High-throughput

0.811

High

1054382

LSM6
LSM complex subunit LSM6

2

6

High-throughput

0.806

High

818486

LSM5
LSM complex subunit LSM5

2

2

High-throughput

0.800

High

1042453

PRP3
U4/U6 small nuclear ribonucleoprotein PRP3

2

1

High-throughput

0.789

High

945351

LSM3
LSM complex subunit LSM3

2

14

Small-scale

0.754

High

1043506

CEF1
Pre-mRNA-splicing factor CEF1

6

2

Small-scale

0.733

High

744167

BRR2
Pre-mRNA-splicing helicase BRR2

6

7

Small-scale

0.720

High

1054390

NCBP2
Nuclear cap-binding protein subunit 2

5

2

High-throughput

0.714

High

1025656

NAM8
Protein NAM8

6

0

Small-scale

0.699

High

757541

NCBP1
Nuclear cap-binding protein complex subunit 1

4

2

High-throughput

0.691

High

918229

SNU71
U1 small nuclear ribonucleoprotein component SNU71

4

0

Small-scale

0.664

High

743559

RU1A
U1 small nuclear ribonucleoprotein A

4

0

Small-scale

0.664

High

886354

PRP31
Pre-mRNA-processing factor 31

3

1

High-throughput

0.662

High

739205

PRP19
Pre-mRNA-processing factor 19

3

2

Small-scale

0.650

High

1037755

CUS1
Cold sensitive U2 snRNA suppressor 1

3

1

High-throughput

0.650

High

1054392

CWC2
Pre-mRNA-splicing factor CWC2

3

1

High-throughput

0.650

High

1054400

BRR1
Pre-mRNA-splicing factor BRR1

1

0

High-throughput

0.631

High

625134

PRP9
Pre-mRNA-splicing factor PRP9

1

1

High-throughput

0.618

High

1054398

PRP46
Pre-mRNA-splicing factor PRP46

2

2

High-throughput

0.611

High

627869

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

2

3

High-throughput

0.601

High

1054386

PRP11
Pre-mRNA-splicing factor PRP11

2

1

High-throughput

0.601

High

1054381

SMD2
Small nuclear ribonucleoprotein Sm D2

1

0

Small-scale

0.586

High

1044063

SNU56
56 kDa U1 small nuclear ribonucleoprotein component

2

0

High-throughput

0.585

High

1053559

SN309
Pre-mRNA-splicing factor SNT309

2

0

High-throughput

0.585

High

1054395

CLF1
Pre-mRNA-splicing factor CLF1

2

6

Small-scale

0.584

High

1054399

SNU66
66 kDa U4/U6.U5 small nuclear ribonucleoprotein component

2

1

Small-scale

0.584

High

750307

PRP40
Pre-mRNA-processing protein PRP40

2

0

High-throughput

0.576

High

1042534

CWC21
Pre-mRNA-splicing factor CWC21

2

0

Small-scale

0.559

High

917485

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

4

High-throughput

0.536

High

925420

EFM6
Protein-lysine N-methyltransferase EFM6

1

1

High-throughput

0.515

High

797794

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.513

High

914883

CWC23
Pre-mRNA-splicing factor CWC23

1

0

High-throughput

0.513

High

1054383

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.513

High

664623

PRP22
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22

1

4

Small-scale

0.501

High

441260

KAPA
cAMP-dependent protein kinase type 1

1

0

High-throughput

0.493

High

864688

TAD2
tRNA-specific adenosine deaminase subunit TAD2

1

0

High-throughput

0.493

High

625048

PRP6
Pre-mRNA-splicing factor 6

1

5

High-throughput

0.479

High

628232

PRP2
Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2

1

4

High-throughput

0.479

High

638018

PRP5
Pre-mRNA-processing ATP-dependent RNA helicase PRP5

1

2

High-throughput

0.479

High

672077

BUD31
Pre-mRNA-splicing factor BUD31

1

1

High-throughput

0.479

High

682390

SPB4
ATP-dependent rRNA helicase SPB4

1

2

High-throughput

0.479

High

739278

PRP21
Pre-mRNA-splicing factor PRP21

1

1

High-throughput

0.479

High

741126

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

2

High-throughput

0.479

High

813373

PRP39
Pre-mRNA-processing factor 39

1

7

High-throughput

0.479

High

829960

PRP17
Pre-mRNA-processing factor 17

1

3

High-throughput

0.479

High

892789

SF3B1
U2 snRNP component HSH155

1

2

High-throughput

0.479

High

1042240

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.479

High

1044040

PRP42
U1 small nuclear ribonucleoprotein component PRP42

1

9

High-throughput

0.479

High

1044946

SYF1
Pre-mRNA-splicing factor SYF1

1

6

High-throughput

0.479

High

1047385

RSE1
Pre-mRNA-splicing factor RSE1

1

1

High-throughput

0.479

High

1054384

DIB1
Spliceosomal protein DIB1

1

1

High-throughput

0.479

High

1054385

RDS3
Pre-mRNA-splicing factor RDS3

1

1

High-throughput

0.479

High

1054393

YRA1
RNA annealing protein YRA1

1

1

High-throughput

0.479

High

1054394

BBP
Branchpoint-bridging protein

1

1

Small-scale

0.479

High

1054401

HSH49
Protein HSH49

1

1

High-throughput

0.479

High

594578

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

Small-scale

0.458

High

603113

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.458

High

638085

ISY1
Pre-mRNA-splicing factor ISY1

1

0

High-throughput

0.458

High

700150

PRP45
Pre-mRNA-processing protein 45

1

0

High-throughput

0.458

High

702284

YJU2
Splicing factor YJU2

1

0

High-throughput

0.458

High

708240

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

735171

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

780860

MUD2
Splicing factor MUD2

1

0

Small-scale

0.458

High

781588

NTR2
Pre-mRNA-splicing factor NTR2

1

0

High-throughput

0.458

High

796185

OLA1
Obg-like ATPase 1

1

0

High-throughput

0.458

High

796466

SLT11
Pre-mRNA-splicing factor SLT11

1

0

High-throughput

0.458

High

797322

SP381
Pre-mRNA-splicing factor SPP381

1

0

High-throughput

0.458

High

797692

NTC20
Pre-mRNA-splicing factor NTC20

1

0

High-throughput

0.458

High

812676

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

865078

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.458

High

897512

UBC9
SUMO-conjugating enzyme UBC9

1

0

High-throughput

0.458

High

919222

SYF2
Pre-mRNA-splicing factor SYF2

1

0

High-throughput

0.458

High

919733

CWC22
Pre-mRNA-splicing factor CWC22

1

0

High-throughput

0.458

High

1026947

PRP38
Pre-mRNA-splicing factor 38

1

0

High-throughput

0.458

High

1038540

SLU7
Pre-mRNA-splicing factor SLU7

1

0

High-throughput

0.458

High

1044023

CWC15
Pre-mRNA-splicing factor CWC15

1

0

High-throughput

0.458

High

1054387

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

1054397

SNU23
23 kDa U4/U6.U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

546359

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

792485

CDC27
Anaphase-promoting complex subunit CDC27

1

0

High-throughput

0.426

High

1025181

SEN1
Helicase SEN1

1

0

Small-scale

0.426

High

804066

FYV4
Small ribosomal subunit protein mS41

1

0

High-throughput

0.282

High

1054389

RRG7
Required for respiratory growth protein 7, mitochondrial

1

0

High-throughput

0.269

Low

918460

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025