HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: RD23B (P54727)
UV excision repair protein RAD23 homolog B (HR23B) (hHR23B) (XP-C repair-complementing complex 58 kDa protein) (p58)
Gene: RAD23B

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	16712842
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	ubiquitin~zf-C3HC4
Common GO terms	GO:0003684 - damaged DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1863 Hs			1 409
+	Hs
		474945 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		UBB_HUMAN (1-79): 1.99e-32: 123: 30.38
+	Mm
		476705 BRCA1_MOUSE (1-1858): 0: 1394: 55.69		UBC_MOUSE (1-118): 1.78e-32: 131: 21.67
+	Hs
		872220 TRI39_HUMAN (15-389): 8.42e-67: 238: 13.19		RD23A_HUMAN (1-409): 9.12e-94: 287: 56.72
+	Hs
		1318716 TRIM5_HUMAN (10-339): 1.37e-63: 227: 13.27		UBQL2_HUMAN (1-364): 5.93e-51: 182: 13.68
+	Hs
		1318731 TRIM4_HUMAN (15-377): 1.5e-62: 225: 11.52		UBQL2_HUMAN (1-364): 5.93e-51: 182: 13.68
+	Hs
		475134 TRI11_HUMAN (11-390): 3.9e-74: 257: 11.49		UBB_HUMAN (1-79): 1.99e-32: 123: 30.38
+	Hs
		1019380 TRI26_HUMAN (12-287): 2.53e-51: 193: 14.53		UBQL2_HUMAN (1-364): 5.93e-51: 182: 13.68
+	Mm
		476831 RO52_MOUSE (14-409): 3.95e-66: 234: 13.40		UBC_MOUSE (1-118): 1.78e-32: 131: 21.67
+	Mm
		924253 RO52_MOUSE (14-409): 3.95e-66: 234: 13.40		RL40_MOUSE (1-99): 3.04e-36: 130: 26.26
+	Mm
		476671 RO52_MOUSE (14-409): 3.95e-66: 234: 13.40		UBB_MOUSE (1-79): 1.53e-31: 123: 30.38
+	Hs
		475177 TRIM5_HUMAN (10-339): 1.37e-63: 227: 13.27		UBB_HUMAN (1-79): 1.99e-32: 123: 30.38
+	Mm
		924236 RO52_MOUSE (14-409): 3.95e-66: 234: 13.40		RS27A_MOUSE (1-90): 2.44e-15: 75: 26.67
+	Hs
		475155 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		UBB_HUMAN (1-79): 1.99e-32: 123: 30.38
+	Hs
		924402 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		RL40_HUMAN (1-91): 3.57e-33: 122: 28.57
+	Mm
		250858 BARD1_MOUSE (13-458): 2.12e-23: 110: 10.89		UBC_MOUSE (1-118): 1.78e-32: 131: 21.67
+	Hs
		924151 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		RS27A_HUMAN (1-90): 2.4e-15: 75: 26.67